KR20040018355A - 낮은 수용해도 약물(ｃｏｘ-2 저해제), 용매, 지방산 및유기아민을 포함하는 경구 송달가능한 약학적 조성물 - Google Patents
낮은 수용해도 약물(ｃｏｘ-2 저해제), 용매, 지방산 및유기아민을 포함하는 경구 송달가능한 약학적 조성물 Download PDFInfo
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- KR20040018355A KR20040018355A KR10-2003-7013651A KR20037013651A KR20040018355A KR 20040018355 A KR20040018355 A KR 20040018355A KR 20037013651 A KR20037013651 A KR 20037013651A KR 20040018355 A KR20040018355 A KR 20040018355A
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- FYZXEMANQYHCFX-UHFFFAOYSA-K tripotassium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [K+].[K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O FYZXEMANQYHCFX-UHFFFAOYSA-K 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000003064 xanthine oxidase inhibitor Substances 0.000 description 1
- 229950000707 ximoprofen Drugs 0.000 description 1
- 229950004227 zaltoprofen Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 108020001588 κ-opioid receptors Proteins 0.000 description 1
- 108020001612 μ-opioid receptors Proteins 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Dispersion Chemistry (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28438101P | 2001-04-17 | 2001-04-17 | |
| US60/284,381 | 2001-04-17 | ||
| US32695201P | 2001-10-04 | 2001-10-04 | |
| US60/326,952 | 2001-10-04 | ||
| PCT/US2002/011689 WO2002083177A1 (en) | 2001-04-17 | 2002-04-12 | Orally deliverable pharmaceutical composition comprising a drug of low water solubility (cox-2 inhibitor), a solvent, a fatty acid and an organic amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20040018355A true KR20040018355A (ko) | 2004-03-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2003-7013651A Ceased KR20040018355A (ko) | 2001-04-17 | 2002-04-12 | 낮은 수용해도 약물(ｃｏｘ-2 저해제), 용매, 지방산 및유기아민을 포함하는 경구 송달가능한 약학적 조성물 |
Country Status (18)
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|---|---|
| US (1) | US20030105141A1 (enExample) |
| EP (1) | EP1379279A1 (enExample) |
| JP (1) | JP2004530669A (enExample) |
| KR (1) | KR20040018355A (enExample) |
| CN (1) | CN1516601A (enExample) |
| AR (1) | AR033221A1 (enExample) |
| AU (1) | AU2002305175B2 (enExample) |
| BR (1) | BR0208994A (enExample) |
| CA (1) | CA2444220A1 (enExample) |
| CZ (1) | CZ20032792A3 (enExample) |
| EA (1) | EA008103B1 (enExample) |
| IL (1) | IL158201A0 (enExample) |
| MX (1) | MXPA03009411A (enExample) |
| NO (1) | NO20034629L (enExample) |
| NZ (1) | NZ528741A (enExample) |
| PE (1) | PE20021145A1 (enExample) |
| PL (1) | PL364524A1 (enExample) |
| WO (1) | WO2002083177A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| EP1344523A1 (en) * | 2002-03-11 | 2003-09-17 | Warner-Lambert Company | Ibuprofen solution for hard gelatin capsules |
| IL164163A0 (en) * | 2002-04-09 | 2005-12-18 | Pharmacia Corp | Process for preparing a finely self-emulsifiable pharmaceutical composition |
| WO2004073492A2 (en) * | 2003-02-14 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof |
| SI2279729T1 (sl) * | 2003-07-17 | 2016-10-28 | Banner Life Sciences, LLC | Pripravki z nadziranim sproščanjem |
| EP1510206A1 (en) * | 2003-08-29 | 2005-03-02 | Novagali Pharma SA | Self-nanoemulsifying oily formulation for the administration of poorly water-soluble drugs |
| CA2569964A1 (en) * | 2004-06-10 | 2005-12-29 | Duramed Pharmaceuticals, Inc. | Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same |
| AU2006214164B2 (en) * | 2005-02-17 | 2010-12-09 | Synta Pharmaceuticals Corp. | Isoxazole combretastin derivatives for the treatment of disorders |
| WO2007050975A2 (en) * | 2005-10-26 | 2007-05-03 | Banner Pharmacaps, Inc. | Hydrophilic vehicle-based dual controlled release matrix system as capsule fill |
| EP1951208A2 (en) | 2005-10-26 | 2008-08-06 | Banner Pharmacaps Inc. | Lipophilic vehicle-based dual controlled release matrix system as capsule fill |
| US8999381B2 (en) * | 2007-09-27 | 2015-04-07 | Wockhardt Ltd. | Self-emulsifying pharmaceutical compositions of rhein or diacerein |
| BRPI0922806B8 (pt) * | 2008-12-03 | 2021-05-25 | Astellas Deutschland Gmbh | composição farmacêutica oral compreendendo bendamustina |
| ES2661812T3 (es) | 2009-10-16 | 2018-04-04 | Mochida Pharmaceutical Co., Ltd. | Composiciones |
| JO3659B1 (ar) | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| EA031793B1 (ru) * | 2010-06-02 | 2019-02-28 | Астеллас Дойчланд Гмбх | Пероральные лекарственные формы бендамустина |
| EP2392319A1 (en) * | 2010-06-04 | 2011-12-07 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical compositions of co-crystals of tramadol and coxibs |
| US8952000B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events |
| US8951514B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels |
| US9119826B2 (en) | 2011-02-16 | 2015-09-01 | Pivotal Therapeutics, Inc. | Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels |
| CA2852618C (en) * | 2011-10-18 | 2019-06-18 | Raqualia Pharma Inc. | Pharmaceutical composition |
| RU2674982C2 (ru) * | 2013-01-14 | 2018-12-14 | ИнФерст Хэлткэр Лимитед | Композиции твердых растворов и их применение при сердечно-сосудистом заболевании |
| HK1218621A1 (zh) * | 2013-02-04 | 2017-03-03 | Infirst Healthcare Limited | 用於治疗慢性炎症和炎性疾病的组合物及方法 |
| WO2015031198A2 (en) | 2013-08-27 | 2015-03-05 | Voudouris Vasilios | Bendamustine pharmaceutical compositions |
| US10731082B2 (en) | 2016-07-05 | 2020-08-04 | Braven Environmental, Llc | System and process for converting waste plastic into fuel |
| US12213510B2 (en) | 2019-09-11 | 2025-02-04 | Nicoventures Trading Limited | Pouched products with enhanced flavor stability |
| CN113750043A (zh) * | 2021-09-18 | 2021-12-07 | 山东省药学科学院 | 一种塞来昔布自乳化口服液及其制备方法 |
| WO2024142089A1 (en) * | 2022-12-27 | 2024-07-04 | Cipla Limited | Injectable compositions of celecoxib |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ276885A (en) * | 1993-11-30 | 1999-08-30 | Searle & Co | Substituted pyrazolyl-benzenesulphonamide derivatives, preparation and pharmaceutical compositions thereof |
| US5571536A (en) * | 1995-02-06 | 1996-11-05 | Nano Systems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
| US5733909A (en) * | 1996-02-01 | 1998-03-31 | Merck Frosst Canada, Inc. | Diphenyl stilbenes as prodrugs to COX-2 inhibitors |
| EP1007049A1 (en) * | 1997-08-27 | 2000-06-14 | Hexal AG | New pharmaceutical compositions of meloxicam with improved solubility and bioavailability |
| US6025353A (en) * | 1997-11-19 | 2000-02-15 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents |
| SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
| AR035642A1 (es) * | 2000-05-26 | 2004-06-23 | Pharmacia Corp | Uso de una composicion de celecoxib para el alivio rapido del dolor |
| JP2004503588A (ja) * | 2000-07-13 | 2004-02-05 | ファルマシア・コーポレーション | 全身性疼痛および頭痛に対する選択的シクロオキシゲナーゼ−２阻害薬および血管調節化合物 |
-
2002
- 2002-04-09 US US10/119,129 patent/US20030105141A1/en not_active Abandoned
- 2002-04-12 NZ NZ528741A patent/NZ528741A/en unknown
- 2002-04-12 WO PCT/US2002/011689 patent/WO2002083177A1/en not_active Ceased
- 2002-04-12 AU AU2002305175A patent/AU2002305175B2/en not_active Ceased
- 2002-04-12 CN CNA028120787A patent/CN1516601A/zh active Pending
- 2002-04-12 EA EA200301019A patent/EA008103B1/ru not_active IP Right Cessation
- 2002-04-12 PL PL02364524A patent/PL364524A1/xx not_active Application Discontinuation
- 2002-04-12 JP JP2002580978A patent/JP2004530669A/ja not_active Withdrawn
- 2002-04-12 CZ CZ20032792A patent/CZ20032792A3/cs unknown
- 2002-04-12 KR KR10-2003-7013651A patent/KR20040018355A/ko not_active Ceased
- 2002-04-12 MX MXPA03009411A patent/MXPA03009411A/es not_active Application Discontinuation
- 2002-04-12 IL IL15820102A patent/IL158201A0/xx unknown
- 2002-04-12 EP EP02733979A patent/EP1379279A1/en not_active Withdrawn
- 2002-04-12 BR BR0208994-7A patent/BR0208994A/pt not_active IP Right Cessation
- 2002-04-12 CA CA002444220A patent/CA2444220A1/en not_active Abandoned
- 2002-04-16 PE PE2002000315A patent/PE20021145A1/es not_active Application Discontinuation
- 2002-04-17 AR ARP020101396A patent/AR033221A1/es unknown
-
2003
- 2003-10-16 NO NO20034629A patent/NO20034629L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002305175B2 (en) | 2007-07-12 |
| JP2004530669A (ja) | 2004-10-07 |
| US20030105141A1 (en) | 2003-06-05 |
| CZ20032792A3 (cs) | 2004-04-14 |
| BR0208994A (pt) | 2004-04-27 |
| NZ528741A (en) | 2005-09-30 |
| PE20021145A1 (es) | 2003-01-16 |
| PL364524A1 (en) | 2004-12-13 |
| WO2002083177A1 (en) | 2002-10-24 |
| NO20034629D0 (no) | 2003-10-16 |
| EP1379279A1 (en) | 2004-01-14 |
| IL158201A0 (en) | 2004-05-12 |
| AR033221A1 (es) | 2003-12-10 |
| NO20034629L (no) | 2003-12-10 |
| EA008103B1 (ru) | 2007-04-27 |
| CN1516601A (zh) | 2004-07-28 |
| CA2444220A1 (en) | 2002-10-24 |
| EA200301019A1 (ru) | 2004-06-24 |
| MXPA03009411A (es) | 2004-01-29 |
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