KR20040010202A - α-케토 산 환원효소, 이의 제조방법, 및 이를 이용한광학적으로 활성인 α-히드록시 산의 제조방법 - Google Patents

α-케토 산 환원효소, 이의 제조방법, 및 이를 이용한광학적으로 활성인 α-히드록시 산의 제조방법 Download PDF

Info

Publication number
KR20040010202A
KR20040010202A KR1020030048385A KR20030048385A KR20040010202A KR 20040010202 A KR20040010202 A KR 20040010202A KR 1020030048385 A KR1020030048385 A KR 1020030048385A KR 20030048385 A KR20030048385 A KR 20030048385A KR 20040010202 A KR20040010202 A KR 20040010202A
Authority
KR
South Korea
Prior art keywords
acid
reductase
protein
keto
keto acid
Prior art date
Application number
KR1020030048385A
Other languages
English (en)
Korean (ko)
Inventor
기모토노리히로
야마모토히로아키
Original Assignee
다이셀 케미칼 인더스트리즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 다이셀 케미칼 인더스트리즈 리미티드 filed Critical 다이셀 케미칼 인더스트리즈 리미티드
Publication of KR20040010202A publication Critical patent/KR20040010202A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020030048385A 2002-07-16 2003-07-15 α-케토 산 환원효소, 이의 제조방법, 및 이를 이용한광학적으로 활성인 α-히드록시 산의 제조방법 KR20040010202A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002207507A JP4154182B2 (ja) 2002-07-16 2002-07-16 α−ケト酸還元酵素、その製造方法、およびこれを利用した光学活性α−ヒドロキシ酸の製造方法
JPJP-P-2002-00207507 2002-07-16

Publications (1)

Publication Number Publication Date
KR20040010202A true KR20040010202A (ko) 2004-01-31

Family

ID=29774623

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020030048385A KR20040010202A (ko) 2002-07-16 2003-07-15 α-케토 산 환원효소, 이의 제조방법, 및 이를 이용한광학적으로 활성인 α-히드록시 산의 제조방법

Country Status (5)

Country Link
US (1) US7250278B2 (fr)
EP (1) EP1382674A3 (fr)
JP (1) JP4154182B2 (fr)
KR (1) KR20040010202A (fr)
CN (1) CN1497046A (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4213524B2 (ja) 2003-04-17 2009-01-21 ダイセル化学工業株式会社 新規なカルボニル還元酵素、その酵素をコードするｄｎａを含むポリヌクレオチド、その製造方法、およびこれを利用した光学活性アルコールの製造方法
JP2006006133A (ja) * 2004-06-23 2006-01-12 Daicel Chem Ind Ltd 光学活性なヒドロキシカルボン酸誘導体の製造方法
WO2007026860A1 (fr) * 2005-09-02 2007-03-08 Daiichi Fine Chemical Co., Ltd. PROCEDE DE FABRICATION D’UN ACIDE α-HYDROXYCARBOXYLIQUE OPTIQUEMENT ACTIF
KR100722155B1 (ko) 2006-01-05 2007-05-28 엔자이텍 주식회사 효소적 방법에 의한 광학활성 2-클로로만델릭산 에스테르와 2-클로로만델릭산의 제조 방법
CN107796904A (zh) * 2016-08-31 2018-03-13 武汉武药制药有限公司 一种用hplc分离测定邻氯扁桃酸对映异构体的方法
CN113355299B (zh) * 2018-03-22 2022-05-24 浙江工业大学 酮酸还原酶、基因、工程菌及在合成手性芳香2-羟酸中的应用
CN109593739B (zh) * 2018-12-30 2020-07-28 浙江工业大学 重组酮酸还原酶突变体、基因、工程菌及其应用
CN113930463B (zh) * 2021-08-30 2023-12-08 上海晖胧生物医药有限公司 一种生物催化2-(苯基羰基)乙腈制备手性扁桃酸的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57198097A (en) 1981-06-01 1982-12-04 Kanegafuchi Chem Ind Co Ltd Preparation of l(+)-mandelic acid
JPS57198096A (en) 1981-06-01 1982-12-04 Kanegafuchi Chem Ind Co Ltd Preparation of d(-)-mandelic acid
DE3320495A1 (de) * 1983-06-07 1984-12-13 Degussa Ag, 6000 Frankfurt Mikrobiologisch hergestellte d-2-hydroxy-4-methylpentansaeure-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung
JPS6332492A (ja) 1986-07-28 1988-02-12 Agency Of Ind Science & Technol 酵素法によるマンデル酸の左旋性光学活性体の製造方法
JP2676568B2 (ja) 1991-06-26 1997-11-17 日東化学工業株式会社 Ｒ（−）−マンデル酸およびその誘導体の製造法
JP3146641B2 (ja) 1992-06-25 2001-03-19 東レ株式会社 光学活性マンデル酸の製造方法
JP2001072644A (ja) 1999-09-06 2001-03-21 Yamakawa Yakuhin Kogyo Kk 光学活性な２−クロロマンデル酸の製造方法および製造の中間体
JP2003199595A (ja) 2001-10-24 2003-07-15 Daicel Chem Ind Ltd 光学活性マンデル酸誘導体の製造方法

Also Published As

Publication number Publication date
EP1382674A3 (fr) 2004-01-28
US7250278B2 (en) 2007-07-31
JP4154182B2 (ja) 2008-09-24
CN1497046A (zh) 2004-05-19
US20040086993A1 (en) 2004-05-06
EP1382674A2 (fr) 2004-01-21
JP2004049028A (ja) 2004-02-19

Similar Documents

Publication Publication Date Title
JP4630486B2 (ja) 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法
US6969600B2 (en) Carbonyl reductase, method for producing said enzyme, DNA encoding said enzyme, and method for producing alcohol using said enzyme
JP4651896B2 (ja) （ｒ）−２−オクタノール脱水素酵素、該酵素の製造方法、該酵素をコードするｄｎａおよびこれを利用したアルコールの製造方法
WO2010024445A1 (fr) Procédé de fabrication d’un dérivé d’amine optiquement actif
JP2005000002A (ja) 新規なカルボニル還元酵素、その酵素をコードするｄｎａを含むポリヌクレオチド、その製造方法、およびこれを利用した光学活性アルコールの製造方法
JP4294382B2 (ja) （２ｓ，３ｓ）−２，３−ブタンジオール脱水素酵素
US7250278B2 (en) α-keto acid reductase, method for producing the same, and method for producing optically active α-hydroxy acids using the same
JP4753273B2 (ja) 光学活性ピリジンエタノール誘導体の製造方法
JP4205496B2 (ja) 新規カルボニル還元酵素及びこれをコードするｄｎａ、ならびにこれらを利用した光学活性アルコールの製造方法
JP4688313B2 (ja) 新規なエノン還元酵素、その製造方法、およびこれを利用したα，β−不飽和ケトンの炭素−炭素２重結合を選択的に還元する方法
JP4587348B2 (ja) 新規な（ｒ）−２，３−ブタンジオール脱水素酵素
JP4295531B2 (ja) 新規カルボニル還元酵素及びこれをコードするｄｎａ、ならびにこれらを利用した光学活性アルコールの製造方法
US7771977B2 (en) Alkane polyol dehydrogenase
JP2005218348A (ja) 光学活性α−ヒドロキシアミドの製造方法
JP4603171B2 (ja) （ｓ）−４−ハロ−３−ヒドロキシ酪酸エステルの製造に有用な酵素をコードする遺伝子、その取得方法、およびこれを利用した光学活性アルコールの製造方法
JP2003339387A (ja) 新規カルボニル還元酵素及びこれをコードする遺伝子、ならびにこれらを利用した光学活性アルコールの製造方法
JP2004065049A (ja) Ｄ−マンデル酸脱水素酵素をコードするポリヌクレオチド、及びその用途
JP2005027552A (ja) 新規な光学活性２−ヒドロキシメチル−３−アリールプロピオン酸の製造方法

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
NORF Unpaid initial registration fee