KR20040004692A - 폴리알킬렌 글리콜을 포함하는 인슐린 약물-올리고머접합체의 혼합물, 그 용도, 및 그 제조방법 - Google Patents

폴리알킬렌 글리콜을 포함하는 인슐린 약물-올리고머접합체의 혼합물, 그 용도, 및 그 제조방법 Download PDF

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Publication number
KR20040004692A
KR20040004692A KR10-2003-7015910A KR20037015910A KR20040004692A KR 20040004692 A KR20040004692 A KR 20040004692A KR 20037015910 A KR20037015910 A KR 20037015910A KR 20040004692 A KR20040004692 A KR 20040004692A
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KR
South Korea
Prior art keywords
mixture
insulin
moiety
polyethylene glycol
oligomer
Prior art date
Application number
KR10-2003-7015910A
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English (en)
Korean (ko)
Inventor
익크유리브녹키리엔.
프라이스크리스토퍼에이치.
안사리아슬람엠.
오덴보우에이미엘.
라드하크리쉬난발라싱암
Original Assignee
노벡스 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 노벡스 코포레이션 filed Critical 노벡스 코포레이션
Publication of KR20040004692A publication Critical patent/KR20040004692A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
KR10-2003-7015910A 2001-06-04 2002-06-04 폴리알킬렌 글리콜을 포함하는 인슐린 약물-올리고머접합체의 혼합물, 그 용도, 및 그 제조방법 KR20040004692A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/873,899 US6828297B2 (en) 2001-06-04 2001-06-04 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US09/873,899 2001-06-04
PCT/US2002/017574 WO2002098232A1 (en) 2001-06-04 2002-06-04 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

Publications (1)

Publication Number Publication Date
KR20040004692A true KR20040004692A (ko) 2004-01-13

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Family Applications (1)

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KR10-2003-7015910A KR20040004692A (ko) 2001-06-04 2002-06-04 폴리알킬렌 글리콜을 포함하는 인슐린 약물-올리고머접합체의 혼합물, 그 용도, 및 그 제조방법

Country Status (14)

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US (3) US6828297B2 (US07470663-20081230-C00012.png)
EP (1) EP1404178B1 (US07470663-20081230-C00012.png)
JP (1) JP5312720B2 (US07470663-20081230-C00012.png)
KR (1) KR20040004692A (US07470663-20081230-C00012.png)
CN (1) CN1538809A (US07470663-20081230-C00012.png)
AR (1) AR034356A1 (US07470663-20081230-C00012.png)
AU (1) AU2002310291B2 (US07470663-20081230-C00012.png)
BR (1) BR0106851A (US07470663-20081230-C00012.png)
CA (1) CA2449426C (US07470663-20081230-C00012.png)
DK (1) DK1404178T3 (US07470663-20081230-C00012.png)
ES (1) ES2564820T3 (US07470663-20081230-C00012.png)
MX (1) MXPA03011284A (US07470663-20081230-C00012.png)
MY (1) MY139375A (US07470663-20081230-C00012.png)
WO (1) WO2002098232A1 (US07470663-20081230-C00012.png)

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