KR20030086062A - 돼지 유행성 설사병 바이러스의 에피토프 단백질을발현하는 형질전환체 및 그를 포함하는 경구투여용백신조성물 - Google Patents
돼지 유행성 설사병 바이러스의 에피토프 단백질을발현하는 형질전환체 및 그를 포함하는 경구투여용백신조성물 Download PDFInfo
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- KR20030086062A KR20030086062A KR1020020024424A KR20020024424A KR20030086062A KR 20030086062 A KR20030086062 A KR 20030086062A KR 1020020024424 A KR1020020024424 A KR 1020020024424A KR 20020024424 A KR20020024424 A KR 20020024424A KR 20030086062 A KR20030086062 A KR 20030086062A
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Abstract
Description
Claims (9)
- 서열번호 1의 PEDV 에피토프 단백질을 암호하는 PEDV 에피토프 유전자를 포함하는 재조합 벡터.상기 서열번호 1에서, X22는 Asp 또는 Gly이고, X23은 Ser 또는 Leu이고, X24는 Ser 또는 Gly이고, X25는 Ser 또는 Gly이고, X51은 Thr 또는 Arg이고, X58은 Asn 또는 Ser이고, X114는 Leu 또는 Phe이고, 및 X137은 Ile 또는 Val이다.
- 제 1항에 있어서, 상기 유전자는 서열번호 2의 서열을 갖는 것인 재조합 벡터.
- 제 1항에 있어서, 상기 재조합 벡터는 식물발현용 프로모터, PEDV 에피토프 유전자 및 전사종결자를 포함하는 것인 재조합 벡터.
- 제 1항에 있어서, 상기 재조합 벡터는 pMYO39(KCTC10194BP)인 것인 재조합 벡터.
- 제 1항의 재조합벡터로 형질전환된 형질전환체.
- 제 5항에 있어서, 상기 형질전환체는 아그로박테리움, 대장균 또는 형질전환식물인 것인 형질전환체.
- 제 6항에 있어서, 상기 식물은 담배, 애기장대, 감자, 상추, 무, 배추, 당근, 토마토, 콩, 쌀, 보리, 밀, 및 옥수수로 이루어진 군으로부터 선택되는 것인 형질전환체.
- 제 5항 또는 제 7항의 형질전환체로부터 분리된 재조합 PEDV 에피토프 단백질.
- 제 5항 또는 제 7항의 형질전환체, 상기 형질전환체의 단백질 추출물 또는 상기 형질전환체로부터 분리된 재조합 PEDV 에피토프 단백질을 포함하는 경구투여용 백신조성물.
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KR10-2002-0024424A KR100509120B1 (ko) | 2002-05-03 | 2002-05-03 | 돼지 유행성 설사병 바이러스의 에피토프 단백질을발현하는 형질전환체 및 그를 포함하는 경구투여용백신조성물 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100884085B1 (ko) * | 2007-07-25 | 2009-02-18 | 대한민국 | 돼지 유행성설사병 바이러스를 중화하는 특이 단클론 항체단쇄가변분절 유전자 및 이를 발현한 재조합단백질 |
KR20120066556A (ko) * | 2010-12-14 | 2012-06-22 | 단국대학교 산학협력단 | 돼지 유행성 설사병 바이러스의 에피토프와 점막면역보조제를 발현하는 형질전환체 및 이를 포함하는 백신 조성물 |
CN103013895A (zh) * | 2011-09-23 | 2013-04-03 | 华中农业大学 | 猪流行性腹泻病毒重组猪霍乱沙门氏菌基因工程活疫苗及制备与应用 |
Family Cites Families (2)
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KR100267749B1 (ko) * | 1998-06-29 | 2000-11-01 | . | 돼지 아데노바이러스 4형 으로부터 제작한 재조합 발현벡터 및그를 이용하여 유전자 재조합 돼지 아데노바이러스 4형을 제조하는 방법 |
KR20030012280A (ko) * | 2001-07-31 | 2003-02-12 | 주식회사 바이오비전텍 | 돼지 유행성 설사병 바이러스에 대한 백신효과를 유도하는형질전환 감자 및 이의 제조방법 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100884085B1 (ko) * | 2007-07-25 | 2009-02-18 | 대한민국 | 돼지 유행성설사병 바이러스를 중화하는 특이 단클론 항체단쇄가변분절 유전자 및 이를 발현한 재조합단백질 |
KR20120066556A (ko) * | 2010-12-14 | 2012-06-22 | 단국대학교 산학협력단 | 돼지 유행성 설사병 바이러스의 에피토프와 점막면역보조제를 발현하는 형질전환체 및 이를 포함하는 백신 조성물 |
CN103013895A (zh) * | 2011-09-23 | 2013-04-03 | 华中农业大学 | 猪流行性腹泻病毒重组猪霍乱沙门氏菌基因工程活疫苗及制备与应用 |
CN103013895B (zh) * | 2011-09-23 | 2014-07-16 | 华中农业大学 | 猪流行性腹泻病毒重组猪霍乱沙门氏菌基因工程活疫苗及制备与应用 |
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