KR20030053530A - 인돌 유도체 및 그 의약용도 - Google Patents

인돌 유도체 및 그 의약용도 Download PDF

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Publication number
KR20030053530A
KR20030053530A KR10-2003-7006870A KR20037006870A KR20030053530A KR 20030053530 A KR20030053530 A KR 20030053530A KR 20037006870 A KR20037006870 A KR 20037006870A KR 20030053530 A KR20030053530 A KR 20030053530A
Authority
KR
South Korea
Prior art keywords
carbon atoms
alkyl
hydrogen
hydroxy
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR10-2003-7006870A
Other languages
English (en)
Korean (ko)
Inventor
사카미사토시
마에다마사유키
카와이코지
아오키타쿠미
우에노신야
Original Assignee
도레이 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 도레이 가부시끼가이샤 filed Critical 도레이 가부시끼가이샤
Publication of KR20030053530A publication Critical patent/KR20030053530A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR10-2003-7006870A 2000-11-22 2001-11-22 인돌 유도체 및 그 의약용도 Ceased KR20030053530A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000356382 2000-11-22
JPJP-P-2000-00356382 2000-11-22
PCT/JP2001/010249 WO2002042309A1 (en) 2000-11-22 2001-11-22 Indole derivatives and use thereof in medicines

Publications (1)

Publication Number Publication Date
KR20030053530A true KR20030053530A (ko) 2003-06-28

Family

ID=18828643

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7006870A Ceased KR20030053530A (ko) 2000-11-22 2001-11-22 인돌 유도체 및 그 의약용도

Country Status (11)

Country Link
US (1) US6770654B2 (https=)
EP (1) EP1342723B1 (https=)
JP (1) JP4292738B2 (https=)
KR (1) KR20030053530A (https=)
CN (1) CN1247591C (https=)
AT (1) ATE402179T1 (https=)
AU (2) AU2408602A (https=)
CA (1) CA2427931A1 (https=)
DE (1) DE60135016D1 (https=)
ES (1) ES2311034T3 (https=)
WO (1) WO2002042309A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1424337A1 (en) * 2002-11-26 2004-06-02 Solvay Pharmaceuticals GmbH 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one
EP1602374A4 (en) * 2003-03-07 2007-03-07 Toray Industries MEANS FOR TREATMENT OF MEDICAMENT / SUBSTANCE DEPENDENCE
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
JPWO2008001859A1 (ja) * 2006-06-30 2009-11-26 学校法人北里研究所 オピオイドδ受容体アゴニスト
EP2149370A1 (en) 2008-07-31 2010-02-03 Neuroscienze Pharmaness S.C. A R.L. Diazabicyclic compounds and microemulsions thereof
IT1390848B1 (it) 2008-07-31 2011-10-19 Neuroscienze Pharmaness S C A R L Composti farmaceutici
IT1396951B1 (it) 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
US20210015813A1 (en) 2018-03-08 2021-01-21 Victoria Link Ltd. Treatment of demyelinating diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849731A (en) * 1995-09-26 1998-12-15 Toray Industries, Inc. Indole derivatives and medical application thereof

Also Published As

Publication number Publication date
EP1342723A1 (en) 2003-09-10
CA2427931A1 (en) 2002-05-30
JP4292738B2 (ja) 2009-07-08
EP1342723A4 (en) 2005-02-09
CN1247591C (zh) 2006-03-29
AU2002224086B1 (en) 2006-11-16
ES2311034T3 (es) 2009-02-01
ATE402179T1 (de) 2008-08-15
DE60135016D1 (de) 2008-09-04
AU2002224086B8 (en) 2002-06-03
JP2002220391A (ja) 2002-08-09
US6770654B2 (en) 2004-08-03
CN1486321A (zh) 2004-03-31
US20040019071A1 (en) 2004-01-29
EP1342723B1 (en) 2008-07-23
AU2408602A (en) 2002-06-03
WO2002042309A1 (en) 2002-05-30

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PA0105 International application

Patent event date: 20030521

Patent event code: PA01051R01D

Comment text: International Patent Application

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PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20061109

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20071031

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20080121

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20071031

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I