KR20030011731A - Antibiotic and cosmetic compositions containing herb medicines - Google Patents

Abstract

PURPOSE: An antimicrobial and cosmetic composition containing an extract of medicinal plants such as Glycyrrhizae Radix, Radix Sophorae Flavescentis or the like is provided. Therefore, this composition is used in manufacture of a cosmetic for nutrient supply, skin regeneration, moisturizing, astrigency, elimination of fine skin wrinkles, aging inhibition or the like and added to a medicament for treatment and improvement of skin diseases, vaginitis, urethritis, cystitis or the like. CONSTITUTION: The cosmetic composition comprises 0.01 to 50% by weight of an extract of two or more selected from the group consisting of Glycyrrhizae Radix, Radix Sophorae Flavescentis, alumen, Belamcandae Rhizoma, Galla Rhois, bamboo shoots, Cnidii Rhizoma, Scutellariae Radix, Coptidis Rhizoma and Phellodendri Cortex. Also, the composition contains additionally one or more selected from the group consisting of Nardostachys chinensis, Angelicae Koreanae Radix, Angelicae Tenuissimae Radix, Cinnamomi Cortex, Lonicerae Flos, Cervi cornu or the like.

Description

Herbal extracts with antibacterial and cosmetic functions and products containing them {Antibiotic and cosmetic compositions containing herb medicines}

The present invention relates to an antimicrobial and cosmetic composition containing a complex herbal extract, and more particularly to an antimicrobial and cosmetic composition containing licorice, red ginseng, alum, dead liver, gall bladder, bamboo shoots, cheongung, golden, yellow lotus or sulfur white extract.

Many antimicrobials are currently commercialized and are widely used for the prevention and treatment of diseases.

Antibacterial agents can be divided into antifungal agents and antibacterial agents according to their antibacterial activity. Antifungal agents have a function of inhibiting or sterilizing the growth of higher organisms having eukaryotic cells such as fungi.

In addition, an antibacterial agent refers to an antibiotic having a function of inhibiting or sterilizing the growth of lower organisms having prokaryotic cells such as bacteria (bacteria).

Until now, mainly antibacterial agents (antifungal agents, antibacterial agents) have been obtained from molds or chemically synthesized.

These antifungal agents include, for example, Amphotericin B, Clotrimazole, Crinipan AD, Fluconazole, Griseofulvin, Haloprogin. Hexachlorophene, Ichthyol, Itraconazole, Ketoconazole, Myconazole, Miconazole, Nystatin (Mycostatin), Pimaricin (Nattamycin) Natamycin)) and Terbinafine.

As antibacterial agents, for example, Adapalene gel, Benzoyl peroxide, Fusidic acid, Resorcinol, Retinoic acid, Salicylic acid ), Sulfonamide, Tetracycline, Triclosan, Penicillin, and the like.

However, these synthetic antifungal and antimicrobial agents have high side-effects such as high manufacturing costs, difficult purification processes, and increased commercialization of microorganisms. In addition, since the cosmetic function has not been reviewed and applied with an ointment, it is accompanied by unwanted skin trouble (contact dermatitis) and side effects, and many researchers have developed antibiotics having the desired antifungal and antibacterial function without side effects. It is known to be in progress.

Accordingly, an object of the present invention is to provide an antimicrobial composition having no side effects such as skin troubles.

Another object of the present invention is to provide an antimicrobial composition that acts on not only one kind of bacteria but also various bacteria and fungi causing skin diseases and skin problems.

Another object of the present invention to provide a cosmetic composition excellent in antimicrobial effect and skin cosmetic improvement effect.

1 is a block diagram for explaining the herbal medicine extraction process of the present invention

Figure 2 is a photograph showing the results of the antimicrobial activity test for athlete's foot fungus-inducing bacteria of the complex herbal extract of the present invention.

Figure 3 is a photograph showing the antimicrobial activity test results for acne-inducing bacteria of the complex herbal extract of the present invention.

Figure 4 is a photograph showing the results of using the product containing a composite herbal extract of the present invention on athlete's foot.

Figure 5 is a photograph showing the results of using a product containing a complex herbal extract of the present invention to acne patients.

Figure 6 is a photograph showing the results of using the product containing the complex herbal extract of the present invention in atopic dermatitis patients.

The object of the present invention is achieved by an antimicrobial composition containing licorice, red ginseng, alum, dead liver, gall bladder, bamboo shoots, celestial organs, golden, yellow lotus or yellow white extract.

The object of the present invention is also achieved by a cosmetic composition containing licorice, red ginseng, alum, dead liver, gall bladder, bamboo shoots, celestial arches, golden, yellow lotus or yellow white extract.

The present inventors, unlike conventional antibacterial agents (antifungal, antibacterial), extracted and purified using a variety of solvents for various herbal drugs applied to skin trouble causing bacteria (acne, athlete's foot, candidiasis, vaginitis, etc.), antibacterial Screening of herbal medicines, and combining each herbal medicine to obtain a composition that is effective in a variety of bacteria and fungi causing skin diseases and skin problems.

In addition, the developed herbal extracts were tested for side effects of each herbal extract and complex extracts.Efficacy on beauty functions (whitening, astringent, exfoliation, antioxidant, wrinkle removal, moisturizing, nutrition, anti-allergy, UV blocking effect, etc.) As a result of the test, it was found that the herbal extract of the present invention has various cosmetic effects.

The present invention was tested by applying various herbal extracts to pathogenic microorganisms (bacteria, fungi, protozoa, etc.) that cause skin diseases (skin problems).

Pathogenic microorganisms (skin trouble-causing bacteria) used in the test are as follows.

① Acne-causing bacteria (1 type): Propionibacterium acnes

② Athlete's foot ( lineworm ) -inducing bacteria (5 species): Epidermophyton floccosum

Microsporum audouinii

Trichophyton ferrugineum

Trichophyton mentagrophytes

Trichophyton rubrum

③ Dandruff-induced bacteria (1 type): Pityrosporum ovale

④ vulvitis or perianal candidiasis-inducing bacteria (1 type): Candida albicans

⑤ Sexually transmitted diseases (feminitis, urethritis, cystitis and men's urethritis)

Causative bacteria (1 species): Trichomonas vaginalis

The above test strain was tested from the strain bank (Korea Advanced Institute of Science and Technology Gene Bank).

The inventors of the present invention first investigated the herbal medicine known as antimicrobial effect in consent consent, Chinese herbal medicine dictionary, herbal medicine, natural product science, Korean herbal medicine, herbal medicine standard, herbal medicine ingredients, herbal medicine, etc. Herbal medicines have been shown to have antimicrobial effects on skin diseases (such as athlete's foot, ringworm, dandruff, vulva and anal candidiasis), and superficial fungi that cause acne and skin problems.

Of these herbal medicines, which are difficult or expensive to purchase in Korea and foreign countries, 155 kinds of herbal medicines used in this test were excluded from the experiment in consideration of economic and mass production system problems. As a result of confirming the antimicrobial activity, a large number of herbal extracts had no or weak antimicrobial activity.

* What is special is that there are herbal medicines that are effective for all experimental bacteria. Some herbal medicines are only effective against acne-causing bacteria, and fungi and athletes have no antimicrobial activity. It was confirmed that there were many differences in the degree of antibacterial activity against five fungi.

In general, antimicrobial activity against dandruff causing bacteria was not found in most herbal extracts (effective concentrations).

In addition, some herbal medicines have a weak antimicrobial activity, but have an excellent effect on cosmetic functions. On the contrary, the antibacterial effect was excellent, but a positive reaction was observed in the patch test.

After selecting an excellent herbal extract in the antimicrobial activity and cosmetic function test as described above, the composite herbal extract of the present invention was developed by mixing and testing the total activity.

The herbal sample preparation process for the experiment is shown in FIG.

First, each herbal medicine is purchased and prepared, followed by quality inspection, washing and extraction. As the extraction solvent, alcohol such as water, methanol or ethanol, 1,3-butylene glycol, propylene glycol, polyethylene glycol, glycerin, ether, or a mixed solvent thereof may be used. Extract so that the ratio of the extract is about 10% by weight, then filtered and purified. After centrifugation using a centrifuge, filtered to remove dietary fibers, etc., and the pigments are removed using activated carbon. Antimicrobial activity and cosmetic function tests were carried out on the primary samples thus prepared, and a secondary sample diluted with an extraction solvent was prepared for the effect recognized in the test results. For example,

Dilute 10% herbal extract to 1/10 to make 1% herbal extract.

Dilute 1% herbal extract to 1/10 to make 0.1% herbal extract.

Dilute 0.1% herbal extract to 1/10 to make 0.01% herbal extract.

The secondary sample prepared in this way is made by recombining a sample having excellent antimicrobial and cosmetic effects, or by extracting a crude compound to be recombinant target to prepare a third sample.

Complex herbal extract of the present invention contains other herbal medicines, for example, saenghyanghyang, strong, hardy, cinnamon, gold and silver, green rust, antler, Angelica, poisonous, machi, fountain blue, Mokhyang, peppermint, baekgangja, baekbaek, baekbu, baekbuja , Baekbokryeong, Baeknyeo, Baekji, Baekpyeon, Seokchangpo, Sangbaekpi, Sesin, Sangup, Small Fennel (Fennel), Aloe, Amaryllis, Ginseng, Ganoderma, Euiin, Yugeunpi, Ginkgo, Wonji, Japonica root One or more of the following elements can be added: crust, fat milk, jihwang, pogongyoung (dandelion), celestial arch, taxi, passerby, hwanggi, hwangjeong, haedongpi.

Complex herbal extract of the present invention is soaps, detergents (vulva cleaner, shampoo, bath products, cleaners for all or part of the body), quasi-drugs / pharmaceuticals, cosmetics (lotion, skin, massage cream, nutrition cream, etc.) ) And noodle products, such as massage packs and socks.

Table 1. Antimicrobial Test Conditions and Methods

Table 2 Antimicrobial Efficacy Test Results

Test conditions and test methods for confirming cosmetic efficacy are described in Table 3 below, and the test results of the herbal ingredients of the present invention carried out by the conditions and methods are described in Table 4 below.

Table 3. Test conditions and methods for confirming cosmetic effects

Table 4. Results of cosmetic efficacy test

The antimicrobial and cosmetic efficacy test results of the tertiary samples prepared by combining the respective herbal medicines confirmed in the above experiments or extracting the herbal compound to be recombinant are described in Table 5 below. The sample concentration of the compound herbal extract was set to 0.15% solution (corresponding to 1.5% of the compound herbal extract) based on the herbal standard using the optimal solvent.

2 to 3, the antimicrobial activity test of the athlete's foot-inducing bacteria and acne-inducing bacteria as shown in Table 1, the experimental results when the paper disk, the cup, and the liquid culture method is shown in the photograph. Minimum growth concentration (MIC) was found below the herbal standard 0.02-0.15% (corresponding to the compound herbal extract 0.2-1.5%).

The MIC of each strain against athlete's foot fungus of E.floccosum (1.0%), M.audouinii (1.5%), T.ferrugineum (1.0%), T.mentagrophytes (0.5%), and T.rubrum (1.0%) It was confirmed that less than, P. acnes (0.02%) in the case of acne-inducing bacteria.

Table 5. Test result of antibacterial and cosmetic effect of complex herbal extract

* Explanation of Symbols: ++++ Very good, +++ Excellent, ++ Effective, + Effective,-No effect

Complex herbal extract of the present invention can be commercialized in a variety of formulations, such as soaps, cosmetics, pharmaceuticals, for example, the following prescription examples.

In addition, when the herbal extract of the present invention is used for treating athlete's foot, for example, tobacco extracts are absorbed into cotton wool wrapped in gauze, and then used as is or prepared in a dry formulation, and then alcohol or the like in use. It can also be manufactured soaked in use. When prepared in this form and applied between the toes can be enhanced the effect of the extract.

Prescription Example 1 Soap (Solid Soap)

Prescription Example 2 Vulva Cleaner (gel-based quasi drug)

Prescription Example 3. Lotion

Prescription Example 4. Ointment

Prescription Example 5 Liquid (Medicine)

Example 1

Soap prepared according to the prescription of Formulation Example 1 was used twice a day for 1 month to a patient with athlete's foot (ringworm). Photos before and after use are posted in FIG. 4.

Example 2

The ointment prepared according to the prescription of Formulation Example 4 was used twice a day for 1 month to patients with acne. Photos before and after use are posted in FIG. 5.

Example 3

The liquid formulation prepared according to the prescription of Formula 5 was used twice a day for 1 month in a pediatric patient with atopic dermatitis. Photos before and after use are posted in FIG. 6.

As can be seen by the experimental results and examples of the present invention, the complex herbal extract of the present invention has excellent antibacterial activity and cosmetic function. Complex herbal extract of the present invention has a whitening function, can be used to remove blemishes, freckles, blotch, nutrition, skin regeneration, moisturizing, convergence, fine wrinkles removal, aging control, exfoliation, UV protection, etc. It can be used to manufacture cosmetics. In addition, acne, athlete's foot, atopic dermatitis, allergic

It can be added to medicines aimed at the treatment of dermatitis, such as contact dermatitis, vulva itch, perianal rash, and sensitive skin, and for the treatment and improvement of female vaginitis, urethritis, cystitis and men's urethritis.

Claims (2)

Cosmetic composition, characterized in that it comprises 0.01-50% by weight each of two or more herbal extracts selected from the group consisting of licorice, red ginseng, alum, mortar, gall bladder, bamboo shoot, celestial organ, golden, yellow lotus and yellow white extract. The method according to claim 1, sensation incense, vigor, hard bones, cinnamon, gold and silver, green, antler, donkey, poisonous, machi, perennial, moth, peppermint, baekjap, baekpyeong, baekbu, baekbuja, baekbokyeong, baekryeom, baekji, baekpyeong, Seokchangpo, Sangbaekpi, Sessin, Sangup, Sohhoe, Aloe, Amaryllis, Ginseng, Ganoderma lucidum, Ui-in, Yu Geun-pi, Ginkgo, Wonji, Japonica root, Peony, Bamboo salt, Crust, Jiyu, Jihwang, Pogongyoung (dandelion), Cheonggung Cosmetic composition, characterized in that it further comprises one or more herbal extracts selected from the group consisting of taxa, passersby, yellow, yellow, and thawed blood.