KR20010101478A - Ｈｉｖ 프로테아제 억제제로서 ｎ-말단에 치환된 벤질기를갖는 비스-아미노산 술폰아미드 - Google Patents

Ｈｉｖ 프로테아제 억제제로서 ｎ-말단에 치환된 벤질기를갖는 비스-아미노산 술폰아미드 Download PDF

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Publication number
KR20010101478A
KR20010101478A KR1020017008803A KR20017008803A KR20010101478A KR 20010101478 A KR20010101478 A KR 20010101478A KR 1020017008803 A KR1020017008803 A KR 1020017008803A KR 20017008803 A KR20017008803 A KR 20017008803A KR 20010101478 A KR20010101478 A KR 20010101478A
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KR
South Korea
Prior art keywords
compound
formula
mmol
hiv
aminophenyl
Prior art date
Application number
KR1020017008803A
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English (en)
Korean (ko)
Inventor
로버트 에프. 칼텐바흐
조지 엘. 트레이너
Original Assignee
블레어 큐. 퍼거슨
듀폰 파마슈티컬즈 컴퍼니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 블레어 큐. 퍼거슨, 듀폰 파마슈티컬즈 컴퍼니 filed Critical 블레어 큐. 퍼거슨
Publication of KR20010101478A publication Critical patent/KR20010101478A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020017008803A 1999-01-13 2000-01-13 Ｈｉｖ 프로테아제 억제제로서 ｎ-말단에 치환된 벤질기를갖는 비스-아미노산 술폰아미드 KR20010101478A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11574699P 1999-01-13 1999-01-13
US60/115,746 1999-01-13
PCT/US2000/000820 WO2000042060A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors

Publications (1)

Publication Number Publication Date
KR20010101478A true KR20010101478A (ko) 2001-11-14

Family

ID=22363180

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017008803A KR20010101478A (ko) 1999-01-13 2000-01-13 Ｈｉｖ 프로테아제 억제제로서 ｎ-말단에 치환된 벤질기를갖는 비스-아미노산 술폰아미드

Country Status (15)

Country Link
EP (1) EP1140983A1 (zh)
JP (1) JP2002536298A (zh)
KR (1) KR20010101478A (zh)
CN (1) CN1336934A (zh)
AU (1) AU2725700A (zh)
BR (1) BR0007854A (zh)
CA (1) CA2353088A1 (zh)
CZ (1) CZ20012435A3 (zh)
HU (1) HUP0105235A3 (zh)
IL (1) IL143763A0 (zh)
NO (1) NO20013338L (zh)
PL (1) PL349774A1 (zh)
SK (1) SK9522001A3 (zh)
TR (1) TR200102033T2 (zh)
WO (1) WO2000042060A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
US6617310B2 (en) * 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843946A (en) * 1992-08-25 1998-12-01 G.D. Searle & Co. α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
TR200102033T2 (tr) 2001-12-21
CZ20012435A3 (cs) 2002-02-13
BR0007854A (pt) 2002-01-15
AU2725700A (en) 2000-08-01
JP2002536298A (ja) 2002-10-29
IL143763A0 (en) 2002-04-21
WO2000042060A1 (en) 2000-07-20
HUP0105235A3 (en) 2002-08-28
EP1140983A1 (en) 2001-10-10
PL349774A1 (en) 2002-09-09
NO20013338L (no) 2001-09-13
CA2353088A1 (en) 2000-07-20
CN1336934A (zh) 2002-02-20
HUP0105235A2 (hu) 2002-04-29
SK9522001A3 (en) 2002-03-05
NO20013338D0 (no) 2001-07-05

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