JP2002536298A - Ｈｉｖプロテアーゼ阻害剤としてｎ末端置換ベンジル基を含むビス−アミノ酸スルホンアミド - Google Patents

Ｈｉｖプロテアーゼ阻害剤としてｎ末端置換ベンジル基を含むビス−アミノ酸スルホンアミド

Info

Publication number
JP2002536298A
JP2002536298A JP2000593627A JP2000593627A JP2002536298A JP 2002536298 A JP2002536298 A JP 2002536298A JP 2000593627 A JP2000593627 A JP 2000593627A JP 2000593627 A JP2000593627 A JP 2000593627A JP 2002536298 A JP2002536298 A JP 2002536298A
Authority
JP
Japan
Prior art keywords
compound
compound according
mmol
formula
hiv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000593627A
Other languages
English (en)
Japanese (ja)
Inventor
エフ．カルテンバッハ ロバート
エル．トレイナー ジョージ
Original Assignee
デュポン ファーマシューティカルズ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デュポン ファーマシューティカルズ カンパニー filed Critical デュポン ファーマシューティカルズ カンパニー
Publication of JP2002536298A publication Critical patent/JP2002536298A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2000593627A 1999-01-13 2000-01-13 Ｈｉｖプロテアーゼ阻害剤としてｎ末端置換ベンジル基を含むビス−アミノ酸スルホンアミド Pending JP2002536298A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11574699P 1999-01-13 1999-01-13
US60/115,746 1999-01-13
PCT/US2000/000820 WO2000042060A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors

Publications (1)

Publication Number Publication Date
JP2002536298A true JP2002536298A (ja) 2002-10-29

Family

ID=22363180

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000593627A Pending JP2002536298A (ja) 1999-01-13 2000-01-13 Ｈｉｖプロテアーゼ阻害剤としてｎ末端置換ベンジル基を含むビス−アミノ酸スルホンアミド

Country Status (15)

Country Link
EP (1) EP1140983A1 (zh)
JP (1) JP2002536298A (zh)
KR (1) KR20010101478A (zh)
CN (1) CN1336934A (zh)
AU (1) AU2725700A (zh)
BR (1) BR0007854A (zh)
CA (1) CA2353088A1 (zh)
CZ (1) CZ20012435A3 (zh)
HU (1) HUP0105235A3 (zh)
IL (1) IL143763A0 (zh)
NO (1) NO20013338L (zh)
PL (1) PL349774A1 (zh)
SK (1) SK9522001A3 (zh)
TR (1) TR200102033T2 (zh)
WO (1) WO2000042060A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
US6617310B2 (en) * 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843946A (en) * 1992-08-25 1998-12-01 G.D. Searle & Co. α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
TR200102033T2 (tr) 2001-12-21
CZ20012435A3 (cs) 2002-02-13
BR0007854A (pt) 2002-01-15
AU2725700A (en) 2000-08-01
IL143763A0 (en) 2002-04-21
WO2000042060A1 (en) 2000-07-20
HUP0105235A3 (en) 2002-08-28
EP1140983A1 (en) 2001-10-10
PL349774A1 (en) 2002-09-09
NO20013338L (no) 2001-09-13
CA2353088A1 (en) 2000-07-20
KR20010101478A (ko) 2001-11-14
CN1336934A (zh) 2002-02-20
HUP0105235A2 (hu) 2002-04-29
SK9522001A3 (en) 2002-03-05
NO20013338D0 (no) 2001-07-05

Similar Documents

Publication Publication Date Title
US6825210B2 (en) Tricyclic compounds useful as HIV reverse transcriptase inhibitors
JP2002536298A (ja) Ｈｉｖプロテアーゼ阻害剤としてｎ末端置換ベンジル基を含むビス−アミノ酸スルホンアミド
US6391919B1 (en) Bis-amino acid sulfonamides containing substituted benzyl amines HIV protease inhibitors
EP0937067B1 (en) 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors
US5932570A (en) 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
US6218386B1 (en) A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
AU722489B2 (en) (4r,5s,6s,7r)-hexahydro-1- {5-(3-aminoinazole)methyl} -3-butyl-5,6-dihydr oxy-4,7-bis {phaenylmethyl} -2h-1,3-diazepin-2-one, its preparation and its use as HIV protease inhibitor
US6313110B1 (en) Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
US6562848B1 (en) Bis-amino acid sulfonamides as HIV protease inhibitors
US6946469B2 (en) Cyanamide, alkoxyamino, and urea derivatives of 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones as HIV reverse transcriptase inhibitors
US20040063734A1 (en) 4,4-Disubstituted-3,4-dihydro-2 (1H)-quinazoliniones useful as HIV reverse transcriptase inhibitors
US7015214B2 (en) Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazepine as HIV reverse transcriptase inhibitors
MXPA01007047A (en) Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors
US20060128634A1 (en) Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors
HRP970595A2 (en) 1-(3-aminoindazol-5-yl)-3-butyl-cyclic urea useful as a hiv proteaze inhibitor
HRP970586A2 (en) 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors
MXPA99004294A (en) (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl]-3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor
MXPA99004286A (en) 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors
AU2002254652A1 (en) Tricyclic compounds useful as HIV reverse transcriptase inhibitors