SK9522001A3 - Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors - Google Patents

Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors Download PDF

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Publication number
SK9522001A3
SK9522001A3 SK952-2001A SK9522001A SK9522001A3 SK 9522001 A3 SK9522001 A3 SK 9522001A3 SK 9522001 A SK9522001 A SK 9522001A SK 9522001 A3 SK9522001 A3 SK 9522001A3
Authority
SK
Slovakia
Prior art keywords
compound
mmol
hiv
formula
group
Prior art date
Application number
SK952-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Robert F Kaltenbach
George L Trainor
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of SK9522001A3 publication Critical patent/SK9522001A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SK952-2001A 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors SK9522001A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11574699P 1999-01-13 1999-01-13
PCT/US2000/000820 WO2000042060A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors

Publications (1)

Publication Number Publication Date
SK9522001A3 true SK9522001A3 (en) 2002-03-05

Family

ID=22363180

Family Applications (1)

Application Number Title Priority Date Filing Date
SK952-2001A SK9522001A3 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors

Country Status (15)

Country Link
EP (1) EP1140983A1 (zh)
JP (1) JP2002536298A (zh)
KR (1) KR20010101478A (zh)
CN (1) CN1336934A (zh)
AU (1) AU2725700A (zh)
BR (1) BR0007854A (zh)
CA (1) CA2353088A1 (zh)
CZ (1) CZ20012435A3 (zh)
HU (1) HUP0105235A3 (zh)
IL (1) IL143763A0 (zh)
NO (1) NO20013338L (zh)
PL (1) PL349774A1 (zh)
SK (1) SK9522001A3 (zh)
TR (1) TR200102033T2 (zh)
WO (1) WO2000042060A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
US6617310B2 (en) * 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843946A (en) * 1992-08-25 1998-12-01 G.D. Searle & Co. α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
TR200102033T2 (tr) 2001-12-21
CZ20012435A3 (cs) 2002-02-13
BR0007854A (pt) 2002-01-15
AU2725700A (en) 2000-08-01
JP2002536298A (ja) 2002-10-29
IL143763A0 (en) 2002-04-21
WO2000042060A1 (en) 2000-07-20
HUP0105235A3 (en) 2002-08-28
EP1140983A1 (en) 2001-10-10
PL349774A1 (en) 2002-09-09
NO20013338L (no) 2001-09-13
CA2353088A1 (en) 2000-07-20
KR20010101478A (ko) 2001-11-14
CN1336934A (zh) 2002-02-20
HUP0105235A2 (hu) 2002-04-29
NO20013338D0 (no) 2001-07-05

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