KR20010075089A - 덴드리머를 사용한 유독 물질의 억제 방법 - Google Patents
덴드리머를 사용한 유독 물질의 억제 방법 Download PDFInfo
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- KR20010075089A KR20010075089A KR1020017003255A KR20017003255A KR20010075089A KR 20010075089 A KR20010075089 A KR 20010075089A KR 1020017003255 A KR1020017003255 A KR 1020017003255A KR 20017003255 A KR20017003255 A KR 20017003255A KR 20010075089 A KR20010075089 A KR 20010075089A
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- Prior art keywords
- dendrimer
- terminal
- solution
- pamam
- lys
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- IAHXTXSDUKSVCL-UHFFFAOYSA-N [4-[carbamothioyl(ethyl)amino]phenyl]methylphosphonic acid;sodium Chemical compound [Na].CCN(C(N)=S)C1=CC=C(CP(O)(O)=O)C=C1 IAHXTXSDUKSVCL-UHFFFAOYSA-N 0.000 description 1
- UVDTWMMVZYACMO-UHFFFAOYSA-N [Na].C1=CC=C2C(NC(=S)N)=CC=C(S(O)(=O)=O)C2=C1 Chemical compound [Na].C1=CC=C2C(NC(=S)N)=CC=C(S(O)(=O)=O)C2=C1 UVDTWMMVZYACMO-UHFFFAOYSA-N 0.000 description 1
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- 239000011230 binding agent Substances 0.000 description 1
- PFYXSUNOLOJMDX-UHFFFAOYSA-N bis(2,5-dioxopyrrolidin-1-yl) carbonate Chemical compound O=C1CCC(=O)N1OC(=O)ON1C(=O)CCC1=O PFYXSUNOLOJMDX-UHFFFAOYSA-N 0.000 description 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
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- BNNQNALSLWKHIV-UHFFFAOYSA-N butanoic acid;1-hydroxypyrrolidine-2,5-dione Chemical compound CCCC(O)=O.ON1C(=O)CCC1=O BNNQNALSLWKHIV-UHFFFAOYSA-N 0.000 description 1
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- 239000002270 dispersing agent Substances 0.000 description 1
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- DUYAAUVXQSMXQP-UHFFFAOYSA-N ethanethioic S-acid Chemical compound CC(S)=O DUYAAUVXQSMXQP-UHFFFAOYSA-N 0.000 description 1
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- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
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- 229940102223 injectable solution Drugs 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
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- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
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- 210000004698 lymphocyte Anatomy 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- FSQQTNAZHBEJLS-UPHRSURJSA-N maleamic acid Chemical class NC(=O)\C=C/C(O)=O FSQQTNAZHBEJLS-UPHRSURJSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
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- 239000003068 molecular probe Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- SENLDUJVTGGYIH-UHFFFAOYSA-N n-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-[2-[bis[3-(2-aminoethylamino)-3-oxopropyl]amino]ethyl]amino]propanamide Chemical compound NCCNC(=O)CCN(CCC(=O)NCCN)CCN(CCC(=O)NCCN)CCC(=O)NCCN SENLDUJVTGGYIH-UHFFFAOYSA-N 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
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- 230000007935 neutral effect Effects 0.000 description 1
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- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- 229960002378 oftasceine Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- RTVVXRKGQRRXFJ-UHFFFAOYSA-N sodium;2-sulfobutanedioic acid Chemical compound [Na].OC(=O)CC(C(O)=O)S(O)(=O)=O RTVVXRKGQRRXFJ-UHFFFAOYSA-N 0.000 description 1
- KSVSZLXDULFGDQ-UHFFFAOYSA-M sodium;4-aminobenzenesulfonate Chemical compound [Na+].NC1=CC=C(S([O-])(=O)=O)C=C1 KSVSZLXDULFGDQ-UHFFFAOYSA-M 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
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- 230000003068 static effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 239000000522 vaginal cream Substances 0.000 description 1
- 239000000259 vaginal foam Substances 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP5843 | 1998-09-14 | ||
| AUPP5843A AUPP584398A0 (en) | 1998-09-14 | 1998-09-14 | Inhibition of toxic materials or substances |
| PCT/AU1999/000762 WO2000015239A1 (en) | 1998-09-14 | 1999-09-13 | Inhibition of toxic materials or substances using dendrimers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010075089A true KR20010075089A (ko) | 2001-08-09 |
Family
ID=3810065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017003255A Ceased KR20010075089A (ko) | 1998-09-14 | 1999-09-13 | 덴드리머를 사용한 유독 물질의 억제 방법 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1113805A4 (https=) |
| JP (1) | JP2002524523A (https=) |
| KR (1) | KR20010075089A (https=) |
| CN (1) | CN1323215A (https=) |
| AU (1) | AUPP584398A0 (https=) |
| BR (1) | BR9913718A (https=) |
| CA (1) | CA2343205A1 (https=) |
| NZ (1) | NZ510376A (https=) |
| WO (1) | WO2000015239A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6720355B2 (en) | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Sodium dodecyl sulfate compositions for inactivating prions |
| AUPP584298A0 (en) * | 1998-09-14 | 1998-10-08 | Starpharma Limited | Antimicrobial and antiparasitic agents |
| MXPA01012357A (es) * | 1999-06-01 | 2002-09-02 | Univ California | Metodos para esterilizar. |
| KR100413532B1 (ko) * | 2001-02-14 | 2003-12-31 | 학교법인 포항공과대학교 | 폴리아민이 말단에 치환된 덴드리머 및 그 제조방법 |
| AUPR412801A0 (en) * | 2001-03-30 | 2001-05-03 | Starpharma Limited | Agent for the prevention and treatment of sexually transmitted disease s - I |
| AUPR412901A0 (en) * | 2001-03-30 | 2001-05-03 | Starpharma Limited | Agents for the prevention and treatment of sexually transmitted disease s - II |
| MXPA05008579A (es) * | 2003-02-13 | 2007-11-21 | Nat Ct Scient Res Demokritos | Dendrimeros multifuncionales y polimeros hiperramificados como sistemas de distribucion de drogas y genes. |
| CN1296711C (zh) * | 2004-05-14 | 2007-01-24 | 沈阳迈迪生物医学技术有限公司 | 乳腺癌的Her－2免疫组织化学诊断试剂盒 |
| PL1937284T3 (pl) * | 2005-10-18 | 2016-05-31 | Starpharma Pty Ltd | System podawania kompozycji bakteriobójczego dendymeru |
| JP5989294B2 (ja) | 2006-01-20 | 2016-09-07 | スターファーマ・プロプライエタリー・リミテッドＳｔａｒｐｈａｒｍａ Ｐｔｙ Ｌｔｄ | 修飾高分子 |
| EP1996209B1 (en) * | 2006-03-22 | 2015-11-04 | Starpharma Pty Limited | Contraceptive composition |
| JP4949206B2 (ja) * | 2007-11-09 | 2012-06-06 | 独立行政法人科学技術振興機構 | 生体分子修飾のためのポリイオンデンドリマー |
| JP4767295B2 (ja) * | 2008-07-17 | 2011-09-07 | 独立行政法人科学技術振興機構 | シトクロムｃ捕捉型アポトーシス抑制剤 |
| CN102743411A (zh) * | 2012-07-25 | 2012-10-24 | 中国人民解放军第四军医大学 | 聚酰胺胺型树枝状大分子在制备预防或治疗脓毒血症的药物中的应用 |
| CN105524285B (zh) * | 2014-10-21 | 2018-06-15 | 浙江大学 | 含硫脲树枝状大分子和含硫脲超支化聚合物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5914095A (en) * | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| JPH10501665A (ja) * | 1994-06-15 | 1998-02-10 | フィリップス エレクトロニクス ネムローゼ フェンノートシャップ | 低電源電圧に関して同相除去をする差動増幅器 |
-
1998
- 1998-09-14 AU AUPP5843A patent/AUPP584398A0/en not_active Abandoned
-
1999
- 1999-09-13 EP EP99945772A patent/EP1113805A4/en not_active Withdrawn
- 1999-09-13 KR KR1020017003255A patent/KR20010075089A/ko not_active Ceased
- 1999-09-13 CN CN99812271A patent/CN1323215A/zh active Pending
- 1999-09-13 NZ NZ510376A patent/NZ510376A/xx unknown
- 1999-09-13 BR BR9913718-6A patent/BR9913718A/pt not_active IP Right Cessation
- 1999-09-13 CA CA002343205A patent/CA2343205A1/en not_active Abandoned
- 1999-09-13 JP JP2000569823A patent/JP2002524523A/ja not_active Withdrawn
- 1999-09-13 WO PCT/AU1999/000762 patent/WO2000015239A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1323215A (zh) | 2001-11-21 |
| EP1113805A1 (en) | 2001-07-11 |
| BR9913718A (pt) | 2001-05-29 |
| JP2002524523A (ja) | 2002-08-06 |
| WO2000015239A1 (en) | 2000-03-23 |
| CA2343205A1 (en) | 2000-03-23 |
| AUPP584398A0 (en) | 1998-10-08 |
| NZ510376A (en) | 2002-10-25 |
| EP1113805A4 (en) | 2004-05-19 |
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