KR20010072472A - 혈뇌장벽 치료제 - Google Patents

혈뇌장벽 치료제 Download PDF

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Publication number
KR20010072472A
KR20010072472A KR1020017001888A KR20017001888A KR20010072472A KR 20010072472 A KR20010072472 A KR 20010072472A KR 1020017001888 A KR1020017001888 A KR 1020017001888A KR 20017001888 A KR20017001888 A KR 20017001888A KR 20010072472 A KR20010072472 A KR 20010072472A
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KR
South Korea
Prior art keywords
cholesterol
oligomer
formula
trp
peptide
Prior art date
Application number
KR1020017001888A
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English (en)
Korean (ko)
Inventor
익크유리브녹키리엔.
라다크리쉬난발라싱암
프라이스크리스토퍼에이치.
앤더슨웨슬리알.주니어
아우사리아슬람엠.
Original Assignee
추후기재
노벡스 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추후기재, 노벡스 코포레이션 filed Critical 추후기재
Publication of KR20010072472A publication Critical patent/KR20010072472A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020017001888A 1998-08-14 1999-08-12 혈뇌장벽 치료제 KR20010072472A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/134,803 1998-08-14
US09/134,803 US6703381B1 (en) 1998-08-14 1998-08-14 Methods for delivery therapeutic compounds across the blood-brain barrier
PCT/US1999/018248 WO2000009073A2 (en) 1998-08-14 1999-08-12 Blood-brain barrier therapeutics

Publications (1)

Publication Number Publication Date
KR20010072472A true KR20010072472A (ko) 2001-07-31

Family

ID=22465087

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017001888A KR20010072472A (ko) 1998-08-14 1999-08-12 혈뇌장벽 치료제

Country Status (11)

Country Link
US (5) US6703381B1 (US20040110735A1-20040610-C00004.png)
EP (1) EP1105142A4 (US20040110735A1-20040610-C00004.png)
JP (1) JP2002522463A (US20040110735A1-20040610-C00004.png)
KR (1) KR20010072472A (US20040110735A1-20040610-C00004.png)
CN (1) CN1323213A (US20040110735A1-20040610-C00004.png)
AU (1) AU772494B2 (US20040110735A1-20040610-C00004.png)
BR (1) BR9914280A (US20040110735A1-20040610-C00004.png)
CA (1) CA2340418A1 (US20040110735A1-20040610-C00004.png)
IL (1) IL141035A0 (US20040110735A1-20040610-C00004.png)
MX (1) MXPA01001694A (US20040110735A1-20040610-C00004.png)
WO (1) WO2000009073A2 (US20040110735A1-20040610-C00004.png)

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WO2000009073A2 (en) 2000-02-24
CN1323213A (zh) 2001-11-21
US6930090B2 (en) 2005-08-16
MXPA01001694A (es) 2002-04-08
EP1105142A2 (en) 2001-06-13
US20040102381A1 (en) 2004-05-27
AU772494B2 (en) 2004-04-29
US20040110735A1 (en) 2004-06-10
AU5672699A (en) 2000-03-06
EP1105142A4 (en) 2002-08-14
IL141035A0 (en) 2002-02-10
US6956051B1 (en) 2005-10-18
CA2340418A1 (en) 2000-02-24
US6703381B1 (en) 2004-03-09
WO2000009073A3 (en) 2000-06-29
US6943148B1 (en) 2005-09-13
BR9914280A (pt) 2001-11-13

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