KR20000030251A - Composition for preventing and treating dandruff - Google Patents

Abstract

PURPOSE: A composition for the prevention and treatment of dandruff is provided which comprises polyhexamethylenebiguaninidine salt. CONSTITUTION: A composition comprises polyhexamethylenebiguaninidine salt by itself, ora mixture of polyhexamethylenebiguaninidine salt and common dandruff-prevention components such as piroctone olamine, zinc pyrithione, diiodomethyl-p-tolylsufone, chlorophenoxyimidazolyldimethylbutanone, and iodopropynylbutylcarbamate. Polyhexamethylenebiguaninidine salt is represented as formula 1 wherein M is selected among phosphoric acid, hydrochloric acid, and sulfuric acid, and n is integer. Preferably 0.1-2.0 wt.% of polyhexamethylenebiguaninidine salts constitute the composition as a single component. 0.001-0.5 wt.% of polyhexamethylenebiguaninidine salt is sufficient for the prevention and treatment of dandruff when it is used as the mixture with one or more component among piroctone olamine, zinc pyrithione, diiodomethyl-p-tolylsufone, chlorophenoxyimidazolyldimethylbutanone, and iodopropynylbutylcarbamate.

Description

Dandruff prevention and treatment composition {COMPOSITION FOR PREVENTING AND TREATING DANDRUFF}

The present invention relates to a composition for preventing and treating dandruff, and more particularly, a composition for preventing and treating dandruff, characterized in that it contains polyhexamethylene biguanidine salt alone or in combination with a conventional anti-dandruff component. It is about.

Dandruff is a natural release of dead cells from the scalp, just as it is on normal skin. Therefore, normal dandruff is invisible and small. However, dandruff usually means that the keratinocytes of the scalp are lumped together with sebum, sweat, etc. secreted from the scalp. This dandruff is caused by the dissolution of sebum components, resulting in the stimulation of cellular overgrowth by stimulating scalp basal layer cells and accompanied by itching. In particular, Pyrosporum ovale, known as the causative agent of dandruff, is known to promote the rancidity of sebum components.

Conventionally, zinc pyrithione was added to hair products for the purpose of treating and preventing dandruff and itching. However, it is difficult to uniformly disperse in the composition because it is water insoluble and has a high specific gravity. Have large disadvantages (see Gene A. Hyde and Mark M. Auerbach, "Formulation Techniques for Zinc Pyrithione Antidandruff Shampoos", Cosmetics and Toiletries, vol. 94, p.57, April 1979; Fred H. Snyder et al. of Zinc 2-Pyridiethiol 1-Oxide in Shampoo Formulation "Toxicology and Applied Pharmacology, vol. 7, p.425-437, 1965). In addition, pyrotonolamine and the like are added to the hair product composition to compensate for the drawbacks of zinc pyrithione, but this component has a weak sterilizing power against dandruff. Salicylic acid is also used as a dandruff prevention, sterilization and keratin dissolving agent, but also has a weak sterilizing power against dandruff.

Thus, the anti-dandruff composition used in conventional anti-dandruff hair products has a common disadvantage that the anti-dandruff and treatment effect is low because the bactericidal power against dandruff bacteria is low.

Therefore, as part of the research to improve these disadvantages, the polyhexamethylene biguananidine salt has excellent anti-dandruff prevention and treatment effect even in the test of the sterilization power against various dandruff bacteria, Even when used together in small amounts, excellent dandruff prevention and treatment effect was found to complete the present invention.

The present invention contains polyhexamethylene biguananidine salt alone or a conventional anti-dandruff component (Piroctone Olamine, trade name: Octopirox (Hoechst)), zinc pyrithione (Zinc Omadine (Olin)) ], Diiodomethyl-p-tolylsulfone [Diiodomethyl-p-tolylsulfone, trade name: Amial (Angus)], chlorophenoxyimidazolyldimethylbutanone, iodopropynylbutylcarbamate, and the like. The present invention relates to a composition having excellent dandruff prevention and therapeutic effect, which is combined with a paper component.

The composition of this invention contains 1 or more types of polyhexamethylene biguanide salt represented by the following general formula (I).

Wherein M is selected from phosphoric acid, hydrochloric acid and sulfuric acid as the salt of polyhexamethylenebiguanide, and n is an integer.

The polyhexamethylene biguanide salt of the present invention is preferably contained in an amount of 0.1 to 2.0% by weight when used alone, the effect is not sufficiently recognized when contained in less than 0.1% by weight and the effect is more than 2.0% when used It does not increase proportionally, resulting in waste of ingredients.

At least one polyhexamethylene biguanide salt selected from the group consisting of pyrotonolamine, zinc pyrithione, diiodomethyl-p-tolylsulfone, chlorophenoxyimidazolyldimethylbutanone and iodopropynylbutylcarbamate When used in combination with the component, the amount of polyhexamethylene biguanide salt used was 0.001% by weight to 0.5% by weight, and there was an effect of preventing and treating dandruff and itching.

The composition of the present invention is polyhexamethylene methylene biguanide salt alone or polyhexamethylene benzanidine salt and green tea for the purpose of preventing and treating dandruff and itching in conventional hair products such as shampoo, hair conditioner, hair tonic, hair spray, hair mousse and the like. One or more components selected from the group consisting of tonolamine, zinc pyrithione, diiodomethyl-p-tolylsulfone, chlorophenoxyimidazolyldimethylbutanone and iodopropynylbutylcarbamate are mixed and used. It is desirable to apply it to shampoos, hair conditioners, hair tonics which are widely used as anti-prevention formulations.

Hereinafter, the present invention will be described in more detail with reference to Examples, but these Examples do not limit the technical scope of the present invention.

Example 1-7 and Comparative Example 1-5

30% sodium lauryl sulfate, 30% polyoxyethylene lauryl sulfate, palm oil fatty acid diethanolamide, propylene glycol and zinc pyrithione according to the present invention, diiodomethyl-p-tolyl sulfone, One of chlorophenoxyimidazolyldimethylbutanone was added to water, and then the mixture was warmed and homogeneously dissolved until it reached 60 ° C, and then cooled to 40 ° C. Subsequently, the mixture was added with iodopropynylbutyl carbamate, polyhexamethylene biguanide salt, pigment (blue No. 1), paraoxybenzoic acid ester, fragrance and citric acid, and cooled to room temperature to prepare a shampoo formulation.

(Unit: weight%) Raw material name Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Sodium Lauryl Sulfate (30%) Polyoxyethylene Sodium Lauryl Sulfate (30%) Sulfone polyhexamethylene biguanine dye dye (blue No. 1) paraoxybenzoic acid ester fragrance (combination fragrance SKP-3473) * citric product 20.020.02.02.0 ---- 0.2 Quantity 0.2 Quantity 20.020.02.02.0 ---- 0.5 Quantity 0.2 Quantity 20.020.02.02.0 ---- 1.5 Quantity 0.2 Quantity 20.020.02.02.00.5 --- 0.2 Quantity 0.2 Quantity 20.020.02.02.0-0.5--0.2 Quantity 0.2 Quantity 20.020.02.02.0--0.5-0.2 Quantity 0.2 Quantity 20.020.02.02.0 --- 0.50.05 appropriate 0.2 appropriate quantity 20.020.02.02.0 ----- Quantity 0.2 20.020.02.02.00.5 ---- quantity 0.2 20.020.02.02.0-0.5 --- Quality 0.2 20.020.02.02.0--0.5--approval 0.2appropriate 20.020.02.02.0--0.5-0.20.2appropriate Add until 100% by weight.

* Hasegawa products

Experiments on the effects of dandruff and itching on the product thus prepared were carried out according to the following test examples and the results are shown in Tables 2, 3 and 5, respectively.

Antidandruff effect test example (1)

Sixty males and females with relatively high dandruff were selected and tested for 1 month of shampoo formulations in Table 1. Before the start of the test, triangulated with dandruff accumulated for 3 days and collected for 3 days, the weight of the collected dandruff, and every 3 days after the end of the test with the shampoo formulation composition shown in Table 1 The weight was compared and evaluated.

At this time, the accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the rate of dandruff reduction was calculated based on the following equation. In addition, the anti-dandruff effect was determined to be effective only when the dandruff reduction rate is 25% or more.

division Average reduction rate (%) Has anti-dandruff effect I do not know No dandruff prevention effect Example 1 43.2 4 people - - Example 2 56.6 5 people - - Example 3 59.2 5 people - - Example 4 56.3 5 people - - Example 5 57.1 5 people - - Example 6 55.2 5 people - - Example 7 44.1 4 people 1 person - Comparative Example 1 5.3 - 1 person 4 people Comparative Example 2 20.8 2 people 1 person 2 people Comparative Example 3 35.8 3 people 1 person 1 person Comparative Example 4 25.8 2 people 1 person 2 people Comparative Example 5 20.6 1 person 2 people 2 people

Antidandruff effect test example (2)

Each shampoo formulation of Table 1 was added to Ym broth containing corn oil at 5, 1, 0.5, 0.1, 0.05, 0.01 and 0.005% by weight, respectively. Was inoculated in 10 ⁵ -10 ⁶ CFU (Colony Forming Unit) / ml and incubated for 2 days. It was. The results are shown in Table 3.

division Minimum Microbial Concentration (MIC,%) Minimum microbial killing concentration (MBC,%) Example 1 0.005-0.01 0.01-0.05 Example 2 Less than 0.005 0.005-0.01 Example 3 Less than 0.005 0.005-0.01 Example 4 Less than 0.005 0.005-0.01 Example 5 Less than 0.005 0.005-0.01 Example 6 Less than 0.005 0.005-0.01 Example 7 0.005-0.01 0.01-0.05 Comparative Example 1 0.5-1 5 or more Comparative Example 2 0.05-0.1 0.1-0.5 Comparative Example 3 0.05-0.1 0.1-0.5 Comparative Example 4 0.05-0.1 0.1-0.5 Comparative Example 5 0.05-0.1 0.1-0.5

Itching test (1)

Sixty men and women who usually felt itching were selected and the products of Table 1 were used once every two days for eight weeks, and then evaluated in accordance with the evaluation criteria of Table 4 through interviews.

Evaluation standard Evaluation Category (Itching Reduction Effect) grade There is so much. 5 have. 4 is average. 3 none. 2 Nothing at all One

division Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Scalp itching effect 3.6 3.8 4.0 3.8 3.8 3.8 3.6 2.2 2.8 3.0 3.0 2.8

As shown in Tables 2, 3 and 5, the shampoo formulations of Examples 1, 2, and 3 containing polyhexamethylene biguananidine salts according to the present invention have anti-dandruff and itching effects than the shampoo formulations of Comparative Example 1. Was excellent in proportion to the concentration of polyhexamethylene biguananidine salts, and polyhexamethylene biguanide salt, pyrotonolamine, zinc pyrithione, diiodomethyl-p-tolylsulfone, and chlorophenoxyimidazolyldi The shampoo formulations of Examples 4, 5, 6, and 7 using a mixture of one or more components selected from the group consisting of methylbutanone and urido propynylbutyl carbamate are superior to the shampoo formulations of Comparative Examples 2, 3, 4 and 5. It can be seen that dandruff and itching are effective.

Examples 8-13 and Comparative Examples 6-9

Cetanol, self-emulsifiable monostearate glycerine, parasyl benzoate, 25% stearyl dimethylbenzyl ammonium chloride, propyleglycol and pyroxtonolamine according to the present invention, zinc pyridion, chloro One of phenoxyimidazolyldimethylbutanone was dissolved by heating to 75 ° C, and the mixture was put in purified water heated to 75 ° C, emulsified, and cooled to 40 ° C. Subsequently, the mixture was mixed with polyhexamethylene biguananidine salt, a dye, a perfume, and citric acid, and cooled to room temperature to prepare a hair conditioner formulation.

Experiments on the effects of dandruff and itching on the product thus prepared were carried out in accordance with the following test example and the results are shown in Table 7, 8 and Table 10, respectively.

(Unit: weight%) Raw material name Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Cetanol Self-Emulsifying Monostearic Acid Glycerin Paraoxybenzoic Acid Esteryl Chloride Stearyl Dimethylbenzyl Ammonium (25%) No. 40) Fragrance (Combination Flavor SKP-3473) 3.01.50.28.02.0 --- 0.2 Quantity 3.01.50.28.02.0 --- 0.5 Quantity 3.01.50.28.02.0 --- 1.5 Quantity 3.01.50.28.02.01.0--0.05 3.01.50.28.02.0-0.5-0.2 3.01.50.28.02.0--0.50.2 3.01.50.28.02.0 ---- quantitative 3.01.50.28.02.01.0 --- quantitative 3.01.50.28.02.0-0.5--appropriate 3.01.50.28.02.0-0.5-quantitative Add until 100% by weight.

* Hasegawa products

Antidandruff effect test example (3)

50 men and women with relatively high dandruff were selected and tested for hair conditioner brothers in Table 6 for one month. Before starting the test, wash with a conventional shampoo, rinse with a conventional hair conditioner, collect dandruff accumulated for 3 days, and use the weight of the collected dandruff once every two days with the composition of the hair conditioner formulation shown in Table 6 above. The weight of the dandruff accumulated three days after the end of the comparison was evaluated. The shampoo used during this test period was the shampoo used before the start of the test.

The results were determined to be effective only when the rate of dandruff reduction is 25% or more, and the dandruff collection and dandruff reduction rate were carried out in the same manner as in Example 1-7.

division Average reduction rate (%) Has anti-dandruff effect I do not know No dandruff prevention effect Example 8 44.5 4 people 1 person - Example 9 53.3 4 people 1 person - Example 10 58.4 5 people - - Example 11 43.7 4 people 1 person - Example 12 55.5 5 people - - Example 13 54.1 4 people 1 person - Comparative Example 6 5.4 - 1 person 4 people Comparative Example 7 20.1 1 person 1 person 3 people Comparative Example 8 28.5 2 people 2 people 1 person Comparative Example 9 25.5 2 people 2 people 1 person

Antidandruff effect test example (4)

Each hair conditioner formulation of Table 6 was added to Ym broth containing corn oil at 5, 1, 0.5, 0.1, 0.05, 0.01 and 0.005% by weight, respectively. Inoculate valerian at an amount of 10 ⁵ -10 ⁶ CFU (Colony Forming Unit) / ml, and incubate for 2 days. Obtained. The results are shown in Table 8.

division Minimum Microbial Concentration (MIC,%) Minimum microbial killing concentration (MBC,%) Example 8 0.005-0.01 0.01-0.05 Example 9 Less than 0.005 0.005-0.01 Example 10 Less than 0.005 0.005-0.01 Example 11 0.005-0.01 0.01-0.05 Example 12 Less than 0.005 0.005-0.01 Example 13 Less than 0.005 0.005-0.01 Comparative Example 6 0.5-1 5 or more Comparative Example 7 0.1-0.5 0.5-1 Comparative Example 8 0.05-0.1 0.1-0.5 Comparative Example 9 0.05-0.1 0.1-0.5

Itching removal effect test example (2)

Fifty men and women who usually had itching were selected and the products in Table 6 were used once every two days for eight weeks, followed by an interview. During this test, the shampoo was made to use the usual shampoo.

Evaluation standard Evaluation Category (Itching Reduction Effect) grade There is so much. 5 have. 4 is average. 3 none. 2 Nothing at all One

division Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Scalp itching effect 3.6 3.8 3.8 3.6 3.8 3.8 1.8 2.4 3.2 3.0

As shown in Tables 7, 8 and 10, the hair conditioner formulations of Examples 8, 9 and 10 containing the polyhexamethylene biguanide salt according to the present invention prevent dandruff and itching than the hair conditioner formulations of Comparative Example 6. The effect was excellent in proportion to the concentration of polyhexamethylene biguanide salt, and a mixture of polyhexamethylene biguanide salt, pyrotonolamine, zinc pyrithione and chlorophenoxyimidazolyldimethylbutanone was used. It can be seen that the hair conditioner formulations of Examples 11, 12, and 13 have better dandruff and itching effects than the hair conditioner formulations of Comparative Examples 6, 7, and 8.

Example 14-18 and Comparative Example 10-12

After mixing and dissolving I-menthol, D-panthenol, propylene glycol, pigments and flavors in ethanol at the composition ratio as shown in Table 11, polyoxyethylene hardened castor oil and polyhexamethylene biguanide salt according to the present invention alone or in advance A hair tonic formulation was prepared by mixing a solution of polyhexamethylene biguananidine salt, pyrotonol amine and diiodomethyl-p-tolylsulfone by mixing and stirring.

Experiments on the effects of dandruff and itching on the product thus prepared were carried out according to the following test example and the results are shown in Table 12 and Table 14.

(Unit: weight%) Raw material name Example 14 Example 15 Example 16 Example 17 Example 18 Comparative Example 10 Comparative Example 11 Comparative Example 12 Ethanol I-Menthol D-Pantenol Propylene Glycol Polyhexamethylene Biguanidine Salt Pyroxtoneolamine Diiodomethyl-p-tolylsulfon Pigment (Blue No. 1) Flavor (Combination Flavor SKP-3473) * Polyoxyethylene Cured Castor Oil 50.00.10.51.00.2--Proper quantity 0.5 50.00.10.51.00.2--Proper quantity 0.5 50.00.10.51.00.2--Proper quantity 0.5 50.00.10.51.00.21.0-appropriate quantity 0.5 50.00.10.51.00.05-0.5Property 0.5 50.00.10.51.0 --- Proper quantity 0.5 50.00.10.51.0-1.0-appropriate quantity 0.5 50.00.10.51.0--0.5Property 0.5 Add until 100% by weight.

* Hasegawa products

Anti-dandruff effect test (5)

Forty men with relatively high dandruff were selected and tested for hair tonic formulations in Table 11 for one month. Before the start of the test, use the hair tonic preparations according to Table 11 above once a day while triturating only the usual shampoo and collecting the dandruff accumulated for 3 days and weighing the amount of dandruff once every two days with the usual shampoo. The weight of the dandruff accumulated three days after the end of the test was evaluated. The shampoo used during this test period was the shampoo used before the start of the test.

The results were determined to be effective only when the rate of dandruff reduction is 25% or more, and the dandruff collection and dandruff reduction rate were carried out in the same manner as in Example 1-7.

division Average reduction rate (%) Has anti-dandruff effect I do not know No dandruff prevention effect Example 14 50.4 4 people 1 person - Example 15 55.3 4 people 1 person - Example 16 60.4 5 people - - Example 17 55.7 4 people 1 person - Example 18 49.1 4 people 1 person - Comparative Example 10 7.3 1 person 3 people 1 person Comparative Example 11 25.5 2 people 1 person 2 people Comparative Example 12 29.8 3 people 1 person 1 person

Itching elimination effect test (3)

Forty men who felt itching were selected and the products in Table 11 were used once a day for four weeks, followed by an interview. During this test, the shampoo was made to use the usual shampoo.

Evaluation standard Evaluation Category (Itching Reduction Effect) grade There is so much. 5 have. 4 is average. 3 none. 2 Nothing at all One

division Example 14 Example 15 Example 16 Example 17 Example 18 Comparative Example 10 Comparative Example 11 Comparative Example 12 Scalp itching effect 3.8 4.0 4.0 4.0 3.8 2.4 3.2 3.2

Therefore, Example 14-18 using the polyhexamethylene biguananidine salt according to the present invention alone or a mixture of polyhexamethylene biguananidine salt, pyrotonolamine and diiodomethyl-p-tolylsulfone was compared with Comparative Example 10-. It has been shown to be more effective in preventing itching than 12.

As described above, the present invention has excellent anti-dandruff and therapeutic effects in any formulation compared to conventional anti-dandruff and therapeutic compositions.

Claims (3)

A composition for preventing and treating dandruff, characterized in that it contains 0.1-2.0% by weight of at least one polyhexamethylene biguanine salt represented by the following general formula (I). Wherein M is selected from phosphoric acid, hydrochloric acid and sulfuric acid as the salt of polyhexamethylenebiguananidine, and n is an integer. The at least one compound according to claim 1, which is selected from the group consisting of pyrotonolamine, zinc pyrithione, diiodomethyl-p-tolylsulfone, chlorophenoxyimidazolyldimethylbutanone and iodopropynylbutylcarbamate A composition further comprising a component. The method according to claim 1 or 2, wherein the polyhexamethylene biguananidine salt of formula (I) is used in an amount of 0.001 to 0.5% by weight when used in combination with at least one component of pyrotonolamine and iodomethyl-p-tolylsulfone. A composition contained in an amount of.