KR19980044042A - Hair cosmetic composition having anti-dandruff effect - Google Patents

Abstract

The present invention relates to a hair cosmetic composition having an anti-dandruff effect, and more particularly, tea tree oil containing terpinen-4-ol (Terpinen-4-ol) as an active ingredient having bactericidal and antimicrobial activity against dandruff ( Tea Tree Oil (oil of Melaleuca alternifolia ) or zinc pyrithione or salicylic acid, which is a well-known antidandruff agent, can continuously provide anti-dandruff and itching effects without hypoxia. It is to provide a hair cosmetic composition that can be.

Description

Hair cosmetic composition having anti-dandruff effect

The present invention relates to a hair cosmetic composition having an anti-dandruff effect, and more particularly, tea tree oil containing terpinen-4-ol (Terpinen-4-ol) as an active ingredient having bactericidal and antimicrobial activity against dandruff ( Tea Tree Oil (oil of Melaleuca alternifolia ) or zinc pyrithione or salicylic acid, which is a well-known antidandruff agent, can continuously provide anti-dandruff and itching effects without hypoxia. It is to provide a hair cosmetic composition that can be.

In general, dandruff refers to the stratum corneum-like mass formed by the dead or peeled cells of the scalp caused by the active metabolism of the human body with the secretion of the scalp sebaceous glands. Dandruff gradually has a clear border with normal skin, becomes red, and increases the scale of the scalp, which usually leads to seborrheic dermatitis with itching and inflammation.

The root cause of such severe dandruff is still unclear, but in general, neurological factors such as endocrine hormone imbalance, metabolic imbalance, stress, biochemical changes in epithelial tissue due to excessive proliferation of scalp cells, It is known to be due to the combined effects of several factors, such as the growth and activity of scalp microorganisms, inflammation caused by air pollution.

In particular, the proliferation and activity of microorganisms called Pityrosporum Ovale, which are present in unclean scalp, have been recognized for a long time as a major factor for worsening dandruff and itching, and are widely accepted in recent years.

Therefore, in the case of hair cosmetics having a dandruff inhibitory action for the purpose of the treatment and prevention of dandruff and itching, it effectively inhibits the growth and activity of the microbial phytirosporum obale which is the main cause of dandruff and prevents abnormal metabolic activity of the scalp cells. It is essential to contain a component that can be normalized.

Thus, as an example of the hair cosmetic composition aimed at suppressing dandruff and itching, the hair cosmetic composition containing zinc pyrithione (zinc-2-pyridinezol-1-oxide) as an active ingredient is mentioned. (US Pat. No. 2,809,971, US Pat. No. 4,323,683, US Pat. No. 4,345,080, US Pat. No. 4,470,982, European Patent No. 285,388.) However, zinc pyrithione has a solubility that is only 15 ppm in 25 ° C water. It is a water-insoluble solid particle having a spherical shape of about 1 μm having a low limit, and it is limited in its usability due to sedimentation due to precipitation in a hair cosmetic composition mainly soluble in water-soluble substrates, especially a shampoo composition. Due to the problem, the content is regulated by the domestic market and the US Food and Drug Administration (FDA).

Accordingly, the present inventors have repeatedly studied to provide a hair cosmetic composition that can continuously obtain a dandruff inhibitory effect without causing hypoallergenic safety problems to the human body, and about the main cause of dandruff occurrence, phytirosporm obale The present invention has been completed by paying attention to the fact that terpinen-4-ol having a bactericidal and antibacterial effect is present in Tea Tree Oil (oil of Melaleuca alternifolia ) in a large amount.

Accordingly, it is an object of the present invention to provide a hair cosmetic composition that can provide an anti-dandruff and itching effect without causing a problem of stability to the human body with low irritation.

In order to achieve the above object, the hair cosmetic composition according to the present invention is characterized by containing tea tree oil in an amount of 0.01 to 10% by weight based on the total weight of the composition.

Other objects and applications of the present invention will become apparent from the following detailed description.

Hereinafter, the present invention will be described in more detail.

Tea tree oil used as an active ingredient exhibiting an anti-dandruff effect in the present invention is an oil obtained by steam distillation of leaves of Melaleuca alternifolia , a species of Australian Myrtaceae.

This tea tree oil contains terpinen-4-ol, pinene, α-terpinene, γ-terpinene, and terpinolene. It contains 50 ingredients such as α-terpineol and 1,8-cineol. Among these ingredients, tea tree oil is an active ingredient terpinene-4- Since all ingredients are contained in an amount of 30.0 to 40.0% by weight, they have bactericidal and antimicrobial activity against microorganisms such as pathogenic fungi, Escherichia coli and staphylococci, which cause eczema and scabies existing on the skin and scalp. In particular, it can inhibit the growth and activity of the microorganism called Pityrosporum Ovale , which is a major cause of worsening dandruff and itching, and can reduce irritation, erythema and seborrheic inflammation.

Tea tree oil used in the present invention can be prepared according to a conventional method, for example, by separating the solution obtained by extracting the leaves of the tea tree by steam distillation.

Tea tree oil used in the hair cosmetic composition of the present invention is used in an amount of 0.01 to 10% by weight, preferably 0.1 to 6% by weight based on the total weight of the composition. If the content of tea tree oil is less than 0.01% by weight, a satisfactory effect is not obtained. If the content of the tea tree oil is more than 10% by weight, anti-dandruff effects cannot be obtained due to excessive growth of the scalp microorganisms.

The hair cosmetic composition of the present invention may have a conventional formulation, for example, may be formulated with shampoo, rinse, hair tonic and the like. The composition of each of these formulations may contain a variety of bases and additives necessary for the formulation of the formulation and are suitable, and the types and amounts of these components can be readily selected by those skilled in the art. Below, representative base shampoo compositions of the hair cosmetic composition will be described, for example, representative base components and additives.

The hair cosmetic composition, especially the shampoo composition, according to the present invention may be composed of a conventional shampoo composition except for tea tree oil, which is an active ingredient. In addition, in order to increase the anti-dandruff effect, zinc pyrithione, which inhibits the growth of microorganisms and increase in activity, salicylic acid and its salts, which remove dandruff by the exfoliation action, does not adversely affect the composition of the present invention. It can be used in combination in amounts that do not cause irritation to the human body.

The essential components and optional components constituting the shampoo composition of the present invention will be described in more detail below.

[Surfactants]

The synthetic surfactant used in the present invention may be any selected from anionic, amphoteric, nonionic and cationic surfactants, and the surfactant is 10 to 70% by weight, preferably 10 to 30% by weight based on the total weight of the composition. %, Most preferably in an amount of 10 to 20% by weight.

Synthetic anionic surfactants that can be used in the present invention are alkyl and alkyl ether sulfates, represented by the following formula (1).

In said formula, R is a C10-C22 alkyl group, n is an integer of 0-4, M is chosen from water-soluble cations, such as ammonium, sodium, and triethanolamine. Preferably, alkyl sulfates and alkyl ether sulfates having 12 to 16 carbon atoms of R are preferable. Alcohols can be derived from or synthesized from fats such as palm oil or tallow. In the present invention, lauryl alcohol and straight chain alcohol derived from palm oil are preferable. This alcohol is reacted with about 1 to 4 moles, especially 3 moles of ethylene oxide, for example to sulfate and neutralize the resulting mixture in a molecule having an average of 3 moles of ethylene oxide per mole of alcohol. Specific examples of these include sodium lauryl sulfate, lauryl ammonium sulfate, lauryl triethanolamine, sodium polyoxyethylene lauryl sulfate, and polyoxyethylene lauryl sulfate.

Synthetic amphoteric surfactants are alkylbetaines and alkylamidopropylbetaines, represented by formulas (2) and (3).

In said formula, R <_1> is a C8-18 alkyl group and R <_2> CO is a C8-18 alkoxy group. Specific examples include cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethyl α-carboxyethylbetaine, cetyldimethylcarboxymethyl, cocoamido propylbetaine and the like.

Synthetic nonionic surfactants are represented by Formulas 4 and 5 as alkanolamides and alkylamine oxides.

In the above formula, R ₁ is an alkyl group having 8 to 18 carbon atoms, R ₂ and R ₃ are alkyl groups having 1 to ₃ carbon atoms, R ₄ CO is an alkoxy group having 8 to 16 carbon atoms, and n is 0 or 1. Specific examples include lauryl diethylamine oxide, palm oil alkyldimethylamine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid monoethanol amide, and the like.

The above-mentioned surfactants can be selected and used alone or in combination in the hair cosmetic composition of the present invention.

[Optional ingredients]

The optional ingredients used in the compositions of the present invention are well known to those skilled in the art as customary optional ingredients for maintaining basic physical properties and quality. As specific examples, pearlescent aids, preservatives, thickeners, viscosity regulators, pH regulators, perfumes, dyes, hair conditioning agents are used.

Pearlescent aids such as, for example, ethylene glycol, monostearate, ethylene glycol distearate; Preservatives such as methyl paraoxybenzoate, methylchloroisothiazolinone and methylisothiazolinone; Viscosity modifiers such as sodium chloride, ammonium chloride, propylene glycol; PH adjusting agents such as citric acid, phosphoric acid, sodium hydroxide, potassium hydroxide; Hair conditioning agents such as polyquaternium-10, polyquaternium-7, methylpolysiloxane, dimethylconcopolyol, hydrolyzed animal protein; Dyestuffs such as water soluble tars are used, and perfumes may be used.

Hair cosmetic composition according to the present invention can be used according to a conventional method of use, the number of times of use can be varied according to the user's scalp state or taste.

Hereinafter, the hair cosmetic composition of the present invention will be described in more detail with reference to examples of the present invention, but the present invention is not limited to these examples.

[Examples 1 to 7 and Comparative Example 1]

Raw material name Comparative example Example One 2 One 2 3 4 5 6 7 1.Sodium polyoxyethylene lauryl ether sulfate 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 2. Sodium Lauryl Sulfate 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 3. Palm oil fatty acid diethanolamide 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 4. Propylene Glycol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 5. Methyl Paraoxybenzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 6. Polyquaternium-7 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 7. Pigment Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity 8. Incense Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity 9. Citric Acid Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity 10. Tea Tree Oil - - 0.2 0.5 2.0 2.0 4.0 4.0 4.0 11.Zincpyrazion - 1.0 - - 1.0 - - 1.0 1.0 12.salicylic acid - - - - - 1.0 - 0.5 13. Add purified water to make 100% by weight.

Test Example 1 Antibacterial Activity Test

The test bacteria were streaked on the agar plates containing the shampoos of the comparative examples and examples according to the concentrations, and the dandruff-causing bacteria were incubated for 2 days under aerobic conditions, followed by observing the growth of bacteria and the lowest inhibition of the growth of test bacteria. The concentration (MIC) was measured to confirm the antimicrobial activity against the causative agent of dandruff.

Test bacteria

Dandruff causing bacteria: Pityrosprum ovale ATCC 12087

2. Medium used

Blood agar medium (blood agar base + final concentration 5%, blood), BHI agar

Minimum Inhibitory Concentration (MIC) Sample Test Bacteria Comparative example Example One 2 3 4 5 6 7 One 2 Fitirosporum Ovalle 0.5 0.35 0.15 0.04 0.012 0.017 0.020 0.008 0.006

As can be seen from Table 1, in the hair cosmetic composition of Examples 1 to 7 containing the tea tree oil of the present invention, the decrease in MIC against dandruff can be seen, and as the content of tea tree oil increases, It can be seen that the degree of reduction is excellent. Thus, the composition of the present invention can be effectively used for the prevention of dandruff production, dandruff treatment and alleviation.

The reduction of MIC was greatest in Examples 4, 6, and 7 using zinc pyrithione or salicylic acid, which are known antidandruff agents, together with the hair cosmetic composition of the present invention.

Test Example 2 Dandruff Reduction Effect Test

54 men aged between 19 and 35 years of age with relatively high dandruff were selected and tested for nine months in six groups of six people in each of the Examples and Comparative Examples, and the results are shown in Table 2.

Trituration with a normal shampoo before the start of the test, and collected the dandruff accumulated for three days after the three-time hair and the weight of the collected dandruff and three times every two days with the hair cosmetic composition of each Example and Comparative Example accumulates three days after the end of the test The weight of the isolated dandruff was evaluated. At this time, the accumulated dandruff was collected directly from the scalp with a vacuum suction device, and the dandruff reduction rate was calculated based on the following equation.

Dandruff Reduction Rate (%) =

Weight of dandruff before start of test (mg)-Weight of dandruff after start of test (mg)

─────────────────────────────── × 100

Weight of dandruff before start of test (mg)

Comparison of the effects of dandruff reduction rate when using shampoo products Comparative example Example One 2 One 2 3 4 5 6 7 Dandruff reduction rate (%) 3.7 16.8 18.1 21.9 41.0 36.5 33.8 52.8 63.1

As shown in Table 2, in the embodiment containing the tea tree oil of the present invention, the average dandruff reduction rate is high, and as the content of tea tree oil increases, the dandruff suppression effect is excellent. In addition, as in Examples 4, 6 and 7, it can be seen that the anti-dandruff effect is further improved when the antipyretic agent known as zinc pyrithione or salicylic acid is contained together.

[Test Example 3] scalp anti-itch effect test

56 men who felt relatively itching were selected and the shampoos of each example and the comparative example were divided into seven groups of eight people for two months and the results are shown in Table 3.

[Evaluation standard]

Very itchy ..... 1 point

Slightly itchy ..... 2 points

Normal ..... 3 points

It is OK ..... 4 points

Not itchy ..... 5 points

Scalp itching effect Comparative example Example One 2 One 2 3 4 5 6 7 Scalp itching effect 1.4 2.6 2.8 3.1 3.8 3.5 3.7 4.1 4.6

As shown in Table 3, it can be seen that the effect of removing the scalp itch in the Example containing tea tree oil of the present invention. Moreover, as the content of tea tree oil is increased, it can be seen that the effect of removing the scalp itch when using zinc pyrithione or salicylic acid together.

As can be seen from the above description, the error correcting capability of Ross bideumgyun form Ovalle proliferation and with the ability of the activity to suppress emitter pinene-4-ol containing a large amount of tea tree days dandruff reduction of the active ingredient and itch suppression of It shows a great effect, and when used together with the known anti-dandruff agent zinc pyrithione or salicylic acid it shows a much better dandruff and itching suppression effect by mutual synergy.

Claims (3)

A hair cosmetic composition, wherein the hair cosmetic composition having an anti-dandruff effect, comprising tea tree oil in an amount of 0.01 to 10% by weight based on the total weight of the composition. The hair cosmetic composition according to claim 1, wherein the tea tree oil is a solution obtained by extracting the leaves of Melaleuca alternifolia by steam distillation. The hair cosmetic composition according to claim 1, further comprising zinc pyrithione or salicylic acid.