KR19990067097A - 성장 호르몬 분비 촉진제의 제조 방법 - Google Patents

성장 호르몬 분비 촉진제의 제조 방법 Download PDF

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Publication number
KR19990067097A
KR19990067097A KR1019980703037A KR19980703037A KR19990067097A KR 19990067097 A KR19990067097 A KR 19990067097A KR 1019980703037 A KR1019980703037 A KR 1019980703037A KR 19980703037 A KR19980703037 A KR 19980703037A KR 19990067097 A KR19990067097 A KR 19990067097A
Authority
KR
South Korea
Prior art keywords
formula
compound
acid
solution
amino
Prior art date
Application number
KR1019980703037A
Other languages
English (en)
Korean (ko)
Inventor
피터 지 휴톤
이오아니스 휴피스
오드리 몰리나
조셉 이 린치
랄프 피 볼란트
Original Assignee
폴락 돈나 엘.
머크 앤드 캄파니 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602949.1A external-priority patent/GB9602949D0/en
Application filed by 폴락 돈나 엘., 머크 앤드 캄파니 인코포레이티드 filed Critical 폴락 돈나 엘.
Publication of KR19990067097A publication Critical patent/KR19990067097A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
KR1019980703037A 1995-10-27 1996-10-23 성장 호르몬 분비 촉진제의 제조 방법 KR19990067097A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US589895P 1995-10-27 1995-10-27
US60/005898 1995-10-27
GB9602949.1 1996-02-13
GBGB9602949.1A GB9602949D0 (en) 1996-02-13 1996-02-13 Process for the preparation of a growth hormone secretagogue
PCT/US1996/016954 WO1997015573A1 (en) 1995-10-27 1996-10-23 Process for the preparation of a growth hormone secretagogue

Publications (1)

Publication Number Publication Date
KR19990067097A true KR19990067097A (ko) 1999-08-16

Family

ID=26308687

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980703037A KR19990067097A (ko) 1995-10-27 1996-10-23 성장 호르몬 분비 촉진제의 제조 방법

Country Status (14)

Country Link
EP (1) EP0863900A1 (pt)
JP (1) JPH11513984A (pt)
KR (1) KR19990067097A (pt)
AR (1) AR004124A1 (pt)
AU (1) AU7468596A (pt)
BR (1) BR9610887A (pt)
CA (1) CA2235511A1 (pt)
CZ (1) CZ128298A3 (pt)
HR (1) HRP960494A2 (pt)
HU (1) HUP9902095A3 (pt)
PL (1) PL326428A1 (pt)
SK (1) SK51198A3 (pt)
WO (1) WO1997015573A1 (pt)
YU (1) YU56596A (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601724D0 (en) * 1996-01-29 1996-03-27 Merck Sharp & Dohme Therapeutic agents
WO1998018815A1 (en) * 1996-10-25 1998-05-07 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
US6329342B1 (en) 1997-08-19 2001-12-11 Eli Lilly And Company Treatment of congestive heart failure with growth hormone secretagogues
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
DE60140285D1 (de) 2000-05-31 2009-12-10 Pfizer Prod Inc Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
ES2266798T3 (es) 2002-04-09 2007-03-01 Eli Lilly And Company Secretagodos de hormona de crecimiento.
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
EP2644618B1 (en) 2007-02-09 2016-08-17 Ocera Therapeutics, Inc. tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT72076A (en) * 1992-12-11 1996-03-28 Merck & Co Inc Process for preparing spiro piperidines and homologs which promote release of growth hormone and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0863900A1 (en) 1998-09-16
SK51198A3 (en) 1998-11-04
PL326428A1 (en) 1998-09-14
HUP9902095A3 (en) 2001-05-28
JPH11513984A (ja) 1999-11-30
WO1997015573A1 (en) 1997-05-01
CZ128298A3 (cs) 1998-07-15
HRP960494A2 (en) 1998-04-30
AR004124A1 (es) 1998-09-30
AU7468596A (en) 1997-05-15
HUP9902095A2 (hu) 1999-10-28
CA2235511A1 (en) 1997-05-01
MX9803316A (es) 1998-09-30
BR9610887A (pt) 1999-07-13
YU56596A (sh) 1999-09-27

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