KR102924196B1 - Kcnq 강화제로서의 1-((2-(2,2,2-트리플루오로에톡시)피리딘-4-일)메틸)우레아 유도체 - Google Patents

Kcnq 강화제로서의 1-((2-(2,2,2-트리플루오로에톡시)피리딘-4-일)메틸)우레아 유도체

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KR102924196B1
KR102924196B1 KR1020217028040A KR20217028040A KR102924196B1 KR 102924196 B1 KR102924196 B1 KR 102924196B1 KR 1020217028040 A KR1020217028040 A KR 1020217028040A KR 20217028040 A KR20217028040 A KR 20217028040A KR 102924196 B1 KR102924196 B1 KR 102924196B1
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pharmaceutically acceptable
acceptable salt
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KR20210126040A (ko
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헬렌 제인 세케레스
앤드류 캐어윈 윌리엄스
마리아 앤 왓튼
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020217028040A 2019-02-06 2020-02-04 Kcnq 강화제로서의 1-((2-(2,2,2-트리플루오로에톡시)피리딘-4-일)메틸)우레아 유도체 Active KR102924196B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962801716P 2019-02-06 2019-02-06
US62/801,716 2019-02-06
US201962811038P 2019-02-27 2019-02-27
US62/811,038 2019-02-27
PCT/US2020/016499 WO2020163268A1 (en) 2019-02-06 2020-02-04 1-((2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methyl)urea derivatives as kcnq potentiators

Publications (2)

Publication Number Publication Date
KR20210126040A KR20210126040A (ko) 2021-10-19
KR102924196B1 true KR102924196B1 (ko) 2026-02-06

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KR1020217028040A Active KR102924196B1 (ko) 2019-02-06 2020-02-04 Kcnq 강화제로서의 1-((2-(2,2,2-트리플루오로에톡시)피리딘-4-일)메틸)우레아 유도체

Country Status (23)

Country Link
US (4) US11208383B2 (https=)
EP (1) EP3921030B1 (https=)
JP (2) JP7451543B2 (https=)
KR (1) KR102924196B1 (https=)
CN (1) CN113692304B (https=)
AU (1) AU2020218180B2 (https=)
BR (1) BR112021015544A2 (https=)
DK (1) DK3921030T3 (https=)
ES (1) ES2968807T3 (https=)
FI (1) FI3921030T3 (https=)
HR (1) HRP20240012T1 (https=)
HU (1) HUE064734T2 (https=)
IL (1) IL285113B2 (https=)
LT (1) LT3921030T (https=)
MX (1) MX2021009396A (https=)
PL (1) PL3921030T3 (https=)
PT (1) PT3921030T (https=)
RS (1) RS65040B1 (https=)
SA (1) SA521422733B1 (https=)
SG (1) SG11202108599SA (https=)
SI (1) SI3921030T1 (https=)
SM (1) SMT202400003T1 (https=)
WO (1) WO2020163268A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20240012T1 (hr) * 2019-02-06 2024-03-29 Eli Lilly And Company Derivati 1-((2-(2,2,2-trifluoroetoksi)piridin-4-il)metil)uree kao kcnq potencijatori
AU2021295422A1 (en) 2020-06-25 2023-02-23 Idorsia Pharmaceuticals Ltd Cyclobutyl-urea derivatives
TW202330471A (zh) * 2021-09-30 2023-08-01 日商住友製藥股份有限公司 環丙醯胺衍生物
EP4433472A1 (en) 2021-11-19 2024-09-25 Icagen, LLC Pyridine compounds as kv7.2 enhancers
JP2024542881A (ja) * 2021-11-19 2024-11-18 アイカジェン・エルエルシー Ｋｖ７．２阻害剤としての新規ヘテロアリール－尿素化合物
EP4452944A1 (en) 2021-12-22 2024-10-30 Icagen, LLC Cyclopropyl compounds
JP2025506201A (ja) 2022-02-15 2025-03-07 アイカジェン・エルエルシー 新規なビシクロペンタン誘導体
IT202200024948A1 (it) * 2022-12-05 2024-06-05 Angelini Pharma S P A Composti attivatori dei canali potassio KV7.2/KV7.3
IT202200024963A1 (it) 2022-12-05 2024-06-05 Angelini Pharma S P A Composti attivatori dei canali potassio Kv7.2/Kv7.3

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103709097A (zh) 2012-09-28 2014-04-09 中国科学院上海药物研究所 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用
WO2015130905A1 (en) 2014-02-27 2015-09-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1257481A (zh) * 1997-03-25 2000-06-21 英国阿斯特拉药品有限公司 新的吡啶衍生物及其含有它们的药用组合物
CN100345823C (zh) * 2003-01-14 2007-10-31 赛特凯恩蒂克公司 化合物、组合物及方法
AU2005233642A1 (en) 2004-04-13 2005-10-27 Astellas Pharma Inc. Polycyclic pyridines as potassium ion channel modulators
CN1993347A (zh) * 2004-07-29 2007-07-04 默克公司 钾通道抑制剂
WO2010036316A1 (en) * 2008-09-24 2010-04-01 Yangbo Feng Urea and carbamate compounds and analogs as kinase inhibitors
KR20120031170A (ko) * 2009-06-08 2012-03-30 길리애드 사이언시즈, 인코포레이티드 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물
CA2828456C (en) * 2011-03-03 2021-05-04 Zalicus Pharmaceuticals Ltd. N-benzl-amino-carboxamide inhibitors of the sodium channel
AR090151A1 (es) 2012-03-07 2014-10-22 Lilly Co Eli Compuestos inhibidores de raf
JP6364472B2 (ja) * 2013-03-15 2018-07-25 デシフェラ ファーマシューティカルズ，エルエルシー 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体
TWI664166B (zh) 2014-10-24 2019-07-01 日商小野藥品工業股份有限公司 Ｋｃｎｑ２至５通道活化劑
JP6943239B2 (ja) * 2016-04-22 2021-09-29 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル活性化剤
HRP20240012T1 (hr) * 2019-02-06 2024-03-29 Eli Lilly And Company Derivati 1-((2-(2,2,2-trifluoroetoksi)piridin-4-il)metil)uree kao kcnq potencijatori

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103709097A (zh) 2012-09-28 2014-04-09 中国科学院上海药物研究所 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用
WO2015130905A1 (en) 2014-02-27 2015-09-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof

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JP2024063191A (ja) 2024-05-10
SMT202400003T1 (it) 2024-03-13
AU2020218180B2 (en) 2025-09-04
HRP20240012T1 (hr) 2024-03-29
ES2968807T3 (es) 2024-05-14
BR112021015544A2 (pt) 2021-10-26
PT3921030T (pt) 2024-01-12
IL285113A (en) 2021-09-30
US11840516B2 (en) 2023-12-12
CN113692304B (zh) 2025-03-18
US11208383B2 (en) 2021-12-28
JP2022519744A (ja) 2022-03-24
US20220073464A1 (en) 2022-03-10
IL285113B2 (en) 2025-10-01
WO2020163268A1 (en) 2020-08-13
LT3921030T (lt) 2024-01-25
CA3128975A1 (en) 2020-08-13
FI3921030T3 (fi) 2024-01-08
DK3921030T3 (da) 2024-01-02
US12344584B2 (en) 2025-07-01
US20200247752A1 (en) 2020-08-06
US20240076269A1 (en) 2024-03-07
US20250282725A1 (en) 2025-09-11
JP7451543B2 (ja) 2024-03-18
HUE064734T2 (hu) 2024-04-28
IL285113B1 (en) 2025-06-01
AU2020218180A1 (en) 2021-08-19
SA521422733B1 (ar) 2024-02-08
SG11202108599SA (en) 2021-09-29
EP3921030B1 (en) 2023-10-11
SI3921030T1 (sl) 2024-03-29
MX2021009396A (es) 2021-09-10
PL3921030T3 (pl) 2024-05-06
EP3921030A1 (en) 2021-12-15
RS65040B1 (sr) 2024-02-29
CN113692304A (zh) 2021-11-23
KR20210126040A (ko) 2021-10-19

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