KR102924196B1 - Kcnq 강화제로서의 1-((2-(2,2,2-트리플루오로에톡시)피리딘-4-일)메틸)우레아 유도체 - Google Patents

Kcnq 강화제로서의 1-((2-(2,2,2-트리플루오로에톡시)피리딘-4-일)메틸)우레아 유도체

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KR102924196B1
KR102924196B1 KR1020217028040A KR20217028040A KR102924196B1 KR 102924196 B1 KR102924196 B1 KR 102924196B1 KR 1020217028040 A KR1020217028040 A KR 1020217028040A KR 20217028040 A KR20217028040 A KR 20217028040A KR 102924196 B1 KR102924196 B1 KR 102924196B1
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pharmaceutically acceptable
acceptable salt
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KR20210126040A (ko
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헬렌 제인 세케레스
앤드류 캐어윈 윌리엄스
마리아 앤 왓튼
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020217028040A 2019-02-06 2020-02-04 Kcnq 강화제로서의 1-((2-(2,2,2-트리플루오로에톡시)피리딘-4-일)메틸)우레아 유도체 Active KR102924196B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962801716P 2019-02-06 2019-02-06
US62/801,716 2019-02-06
US201962811038P 2019-02-27 2019-02-27
US62/811,038 2019-02-27
PCT/US2020/016499 WO2020163268A1 (en) 2019-02-06 2020-02-04 1-((2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methyl)urea derivatives as kcnq potentiators

Publications (2)

Publication Number Publication Date
KR20210126040A KR20210126040A (ko) 2021-10-19
KR102924196B1 true KR102924196B1 (ko) 2026-02-06

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KR1020217028040A Active KR102924196B1 (ko) 2019-02-06 2020-02-04 Kcnq 강화제로서의 1-((2-(2,2,2-트리플루오로에톡시)피리딘-4-일)메틸)우레아 유도체

Country Status (23)

Country Link
US (4) US11208383B2 (https=)
EP (1) EP3921030B1 (https=)
JP (2) JP7451543B2 (https=)
KR (1) KR102924196B1 (https=)
CN (1) CN113692304B (https=)
AU (1) AU2020218180B2 (https=)
BR (1) BR112021015544A2 (https=)
DK (1) DK3921030T3 (https=)
ES (1) ES2968807T3 (https=)
FI (1) FI3921030T3 (https=)
HR (1) HRP20240012T1 (https=)
HU (1) HUE064734T2 (https=)
IL (1) IL285113B2 (https=)
LT (1) LT3921030T (https=)
MX (1) MX2021009396A (https=)
PL (1) PL3921030T3 (https=)
PT (1) PT3921030T (https=)
RS (1) RS65040B1 (https=)
SA (1) SA521422733B1 (https=)
SG (1) SG11202108599SA (https=)
SI (1) SI3921030T1 (https=)
SM (1) SMT202400003T1 (https=)
WO (1) WO2020163268A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE064734T2 (hu) * 2019-02-06 2024-04-28 Lilly Co Eli 1-((2-(2,2,2-trifluoretoxi)piridin-4-il)metil)karbamid származékok mint KCNQ potenciátorok
CA3183298A1 (en) 2020-06-25 2021-12-30 Olivier Bezencon Cyclobutyl-urea derivatives
TW202330471A (zh) * 2021-09-30 2023-08-01 日商住友製藥股份有限公司 環丙醯胺衍生物
WO2023091554A1 (en) * 2021-11-19 2023-05-25 Icagen, Llc Novel heteroaryl-urea compounds as kv7.2 inhibitors
EP4433472A1 (en) 2021-11-19 2024-09-25 Icagen, LLC Pyridine compounds as kv7.2 enhancers
JP2025502712A (ja) 2021-12-22 2025-01-28 アイカジェン・エルエルシー シクロプロピル化合物
EP4479377A1 (en) 2022-02-15 2024-12-25 Icagen, LLC New bicyclopentane derivatives
IT202200024963A1 (it) * 2022-12-05 2024-06-05 Angelini Pharma S P A Composti attivatori dei canali potassio Kv7.2/Kv7.3
IT202200024948A1 (it) * 2022-12-05 2024-06-05 Angelini Pharma S P A Composti attivatori dei canali potassio KV7.2/KV7.3

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN103709097A (zh) 2012-09-28 2014-04-09 中国科学院上海药物研究所 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用
WO2015130905A1 (en) 2014-02-27 2015-09-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof

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PL335905A1 (en) * 1997-03-25 2000-05-22 Astra Pharma Prod Novel derivatives of pyridine and pharmaceutic compositions containing them
CN100345823C (zh) * 2003-01-14 2007-10-31 赛特凯恩蒂克公司 化合物、组合物及方法
KR20070030196A (ko) 2004-04-13 2007-03-15 이카겐, 인코포레이티드 칼륨 이온 채널 조절제로서의 폴리시클릭 피리딘
US7879839B2 (en) * 2004-07-29 2011-02-01 Merck Sharp & Dohme Corp. Potassium channel inhibitors
WO2010036316A1 (en) 2008-09-24 2010-04-01 Yangbo Feng Urea and carbamate compounds and analogs as kinase inhibitors
KR20120031170A (ko) * 2009-06-08 2012-03-30 길리애드 사이언시즈, 인코포레이티드 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물
EP2681200A4 (en) * 2011-03-03 2015-05-27 Zalicus Pharmaceuticals Ltd INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL
AR090151A1 (es) 2012-03-07 2014-10-22 Lilly Co Eli Compuestos inhibidores de raf
RU2769607C2 (ru) 2013-03-15 2022-04-04 ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи N-ацил-N'-(пиридин-2-ил) карбамиды и их аналоги, проявляющие противораковую и антипролиферативную активность
CA2965467A1 (en) * 2014-10-24 2016-04-28 Ono Pharmaceutical Co., Ltd. Kcnq2-5 channel activator
EP3447045B9 (en) 2016-04-22 2021-07-21 ONO Pharmaceutical Co., Ltd. 1-(1-hydroxy-2,3-dihydro-1h-inden-5-yl)-urea derivatives and related compounds kcnq 2-5 channel activators for treating dysuria
HUE064734T2 (hu) * 2019-02-06 2024-04-28 Lilly Co Eli 1-((2-(2,2,2-trifluoretoxi)piridin-4-il)metil)karbamid származékok mint KCNQ potenciátorok

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103709097A (zh) 2012-09-28 2014-04-09 中国科学院上海药物研究所 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用
WO2015130905A1 (en) 2014-02-27 2015-09-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof

Also Published As

Publication number Publication date
KR20210126040A (ko) 2021-10-19
BR112021015544A2 (pt) 2021-10-26
US11208383B2 (en) 2021-12-28
IL285113B2 (en) 2025-10-01
CN113692304B (zh) 2025-03-18
PT3921030T (pt) 2024-01-12
IL285113B1 (en) 2025-06-01
HRP20240012T1 (hr) 2024-03-29
US20250282725A1 (en) 2025-09-11
HUE064734T2 (hu) 2024-04-28
JP2024063191A (ja) 2024-05-10
US20220073464A1 (en) 2022-03-10
LT3921030T (lt) 2024-01-25
EP3921030A1 (en) 2021-12-15
CN113692304A (zh) 2021-11-23
AU2020218180A1 (en) 2021-08-19
ES2968807T3 (es) 2024-05-14
FI3921030T3 (fi) 2024-01-08
US20240076269A1 (en) 2024-03-07
SA521422733B1 (ar) 2024-02-08
RS65040B1 (sr) 2024-02-29
JP7451543B2 (ja) 2024-03-18
JP2022519744A (ja) 2022-03-24
US11840516B2 (en) 2023-12-12
IL285113A (en) 2021-09-30
SI3921030T1 (sl) 2024-03-29
US12344584B2 (en) 2025-07-01
US20200247752A1 (en) 2020-08-06
AU2020218180B2 (en) 2025-09-04
MX2021009396A (es) 2021-09-10
PL3921030T3 (pl) 2024-05-06
EP3921030B1 (en) 2023-10-11
CA3128975A1 (en) 2020-08-13
SG11202108599SA (en) 2021-09-29
SMT202400003T1 (it) 2024-03-13
DK3921030T3 (da) 2024-01-02
WO2020163268A1 (en) 2020-08-13

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