KR102898177B1 - 단백질 제제를 위한 트립토판 유도체 및 l-메티오닌의 용도 - Google Patents

단백질 제제를 위한 트립토판 유도체 및 l-메티오닌의 용도

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Publication number
KR102898177B1
KR102898177B1 KR1020217006484A KR20217006484A KR102898177B1 KR 102898177 B1 KR102898177 B1 KR 102898177B1 KR 1020217006484 A KR1020217006484 A KR 1020217006484A KR 20217006484 A KR20217006484 A KR 20217006484A KR 102898177 B1 KR102898177 B1 KR 102898177B1
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KR
South Korea
Prior art keywords
antibody
delete delete
methionine
polypeptide
formulation
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KR1020217006484A
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English (en)
Korean (ko)
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KR20210042936A (ko
Inventor
클레오 살리스버리
비카스 샤르마
스리드하라 알라바탐
Original Assignee
제넨테크, 인크.
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Publication of KR20210042936A publication Critical patent/KR20210042936A/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
KR1020217006484A 2018-08-08 2019-08-07 단백질 제제를 위한 트립토판 유도체 및 l-메티오닌의 용도 Active KR102898177B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862716239P 2018-08-08 2018-08-08
US62/716,239 2018-08-08
PCT/US2019/045420 WO2020033485A1 (en) 2018-08-08 2019-08-07 Use of tryptophan derivatives and l-methionine for protein formulation

Publications (2)

Publication Number Publication Date
KR20210042936A KR20210042936A (ko) 2021-04-20
KR102898177B1 true KR102898177B1 (ko) 2025-12-10

Family

ID=67777405

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217006484A Active KR102898177B1 (ko) 2018-08-08 2019-08-07 단백질 제제를 위한 트립토판 유도체 및 l-메티오닌의 용도

Country Status (14)

Country Link
US (1) US20210155715A1 (enExample)
EP (1) EP3833389A1 (enExample)
JP (1) JP7542521B2 (enExample)
KR (1) KR102898177B1 (enExample)
CN (1) CN112770775A (enExample)
AR (1) AR115925A1 (enExample)
AU (1) AU2019319822B2 (enExample)
BR (1) BR112021002130A2 (enExample)
CA (1) CA3106537A1 (enExample)
IL (1) IL280525B2 (enExample)
MX (1) MX428673B (enExample)
SG (1) SG11202100601TA (enExample)
TW (1) TWI924628B (enExample)
WO (1) WO2020033485A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202545564A (zh) * 2022-04-13 2025-12-01 美商建南德克公司 治療性蛋白質之醫藥組成物及使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017117304A1 (en) * 2015-12-30 2017-07-06 Genentech, Inc. Use of tryptophan derivatives for protein formulations

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Also Published As

Publication number Publication date
WO2020033485A1 (en) 2020-02-13
BR112021002130A2 (pt) 2021-05-04
JP2021533149A (ja) 2021-12-02
AR115925A1 (es) 2021-03-10
IL280525A (en) 2021-03-01
SG11202100601TA (en) 2021-02-25
KR20210042936A (ko) 2021-04-20
JP7542521B2 (ja) 2024-08-30
TWI924628B (zh) 2026-05-11
TW202019478A (zh) 2020-06-01
AU2019319822B2 (en) 2026-04-16
US20210155715A1 (en) 2021-05-27
MX2021001453A (es) 2021-04-12
IL280525B1 (en) 2024-07-01
AU2019319822A1 (en) 2021-03-18
EP3833389A1 (en) 2021-06-16
IL280525B2 (en) 2024-11-01
CA3106537A1 (en) 2020-02-13
MX428673B (es) 2025-11-13
CN112770775A (zh) 2021-05-07

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