AR115925A1 - Uso de derivados de triptófano y l-metionina para formulación de proteínas - Google Patents

Uso de derivados de triptófano y l-metionina para formulación de proteínas

Info

Publication number
AR115925A1
AR115925A1 ARP190102242A ARP190102242A AR115925A1 AR 115925 A1 AR115925 A1 AR 115925A1 AR P190102242 A ARP190102242 A AR P190102242A AR P190102242 A ARP190102242 A AR P190102242A AR 115925 A1 AR115925 A1 AR 115925A1
Authority
AR
Argentina
Prior art keywords
tryptophan
protein formulation
methionine derivatives
methionine
polypeptide
Prior art date
Application number
ARP190102242A
Other languages
English (en)
Inventor
Vikas Sharma
Cleo Salisbury
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR115925A1 publication Critical patent/AR115925A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Abstract

La presente descripción proporciona métodos y formulaciones que comprenden un polipéptido que comprende residuos de aminoácidos accesibles al solvente susceptibles a la oxidación, en donde se usa N-acetil-DL-triptófano (NAT) y/o L-metionina para evitar la oxidación del polipéptido.
ARP190102242A 2018-08-08 2019-08-07 Uso de derivados de triptófano y l-metionina para formulación de proteínas AR115925A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862716239P 2018-08-08 2018-08-08

Publications (1)

Publication Number Publication Date
AR115925A1 true AR115925A1 (es) 2021-03-10

Family

ID=67777405

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190102242A AR115925A1 (es) 2018-08-08 2019-08-07 Uso de derivados de triptófano y l-metionina para formulación de proteínas

Country Status (14)

Country Link
US (1) US20210155715A1 (es)
EP (1) EP3833389A1 (es)
JP (1) JP2021533149A (es)
KR (1) KR20210042936A (es)
CN (1) CN112770775A (es)
AR (1) AR115925A1 (es)
AU (1) AU2019319822A1 (es)
BR (1) BR112021002130A2 (es)
CA (1) CA3106537A1 (es)
IL (1) IL280525A (es)
MX (1) MX2021001453A (es)
SG (1) SG11202100601TA (es)
TW (1) TW202019478A (es)
WO (1) WO2020033485A1 (es)

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Also Published As

Publication number Publication date
SG11202100601TA (en) 2021-02-25
CN112770775A (zh) 2021-05-07
TW202019478A (zh) 2020-06-01
IL280525A (en) 2021-03-01
WO2020033485A1 (en) 2020-02-13
CA3106537A1 (en) 2020-02-13
AU2019319822A1 (en) 2021-03-18
BR112021002130A2 (pt) 2021-05-04
JP2021533149A (ja) 2021-12-02
KR20210042936A (ko) 2021-04-20
US20210155715A1 (en) 2021-05-27
MX2021001453A (es) 2021-04-12
EP3833389A1 (en) 2021-06-16

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