AU2019319822B2 - Use of tryptophan derivatives and L-methionine for protein formulation - Google Patents

Use of tryptophan derivatives and L-methionine for protein formulation

Info

Publication number
AU2019319822B2
AU2019319822B2 AU2019319822A AU2019319822A AU2019319822B2 AU 2019319822 B2 AU2019319822 B2 AU 2019319822B2 AU 2019319822 A AU2019319822 A AU 2019319822A AU 2019319822 A AU2019319822 A AU 2019319822A AU 2019319822 B2 AU2019319822 B2 AU 2019319822B2
Authority
AU
Australia
Prior art keywords
antibody
formulation
methionine
nat
oxidation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019319822A
Other languages
English (en)
Other versions
AU2019319822A1 (en
Inventor
Sreedhara Alavattam
Cleo Salisbury
Vikas Sharma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AU2019319822A1 publication Critical patent/AU2019319822A1/en
Application granted granted Critical
Publication of AU2019319822B2 publication Critical patent/AU2019319822B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
AU2019319822A 2018-08-08 2019-08-07 Use of tryptophan derivatives and L-methionine for protein formulation Active AU2019319822B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862716239P 2018-08-08 2018-08-08
US62/716,239 2018-08-08
PCT/US2019/045420 WO2020033485A1 (en) 2018-08-08 2019-08-07 Use of tryptophan derivatives and l-methionine for protein formulation

Publications (2)

Publication Number Publication Date
AU2019319822A1 AU2019319822A1 (en) 2021-03-18
AU2019319822B2 true AU2019319822B2 (en) 2026-04-16

Family

ID=67777405

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019319822A Active AU2019319822B2 (en) 2018-08-08 2019-08-07 Use of tryptophan derivatives and L-methionine for protein formulation

Country Status (14)

Country Link
US (1) US20210155715A1 (enExample)
EP (1) EP3833389A1 (enExample)
JP (1) JP7542521B2 (enExample)
KR (1) KR102898177B1 (enExample)
CN (1) CN112770775A (enExample)
AR (1) AR115925A1 (enExample)
AU (1) AU2019319822B2 (enExample)
BR (1) BR112021002130A2 (enExample)
CA (1) CA3106537A1 (enExample)
IL (1) IL280525B2 (enExample)
MX (1) MX428673B (enExample)
SG (1) SG11202100601TA (enExample)
TW (1) TWI924628B (enExample)
WO (1) WO2020033485A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202545564A (zh) * 2022-04-13 2025-12-01 美商建南德克公司 治療性蛋白質之醫藥組成物及使用方法

Citations (2)

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WO2017117304A1 (en) * 2015-12-30 2017-07-06 Genentech, Inc. Use of tryptophan derivatives for protein formulations
US20170196837A1 (en) * 2013-03-13 2017-07-13 Genentech, Inc. Formulations with reduced oxidation

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Also Published As

Publication number Publication date
WO2020033485A1 (en) 2020-02-13
BR112021002130A2 (pt) 2021-05-04
JP2021533149A (ja) 2021-12-02
AR115925A1 (es) 2021-03-10
IL280525A (en) 2021-03-01
SG11202100601TA (en) 2021-02-25
KR20210042936A (ko) 2021-04-20
JP7542521B2 (ja) 2024-08-30
TWI924628B (zh) 2026-05-11
TW202019478A (zh) 2020-06-01
US20210155715A1 (en) 2021-05-27
MX2021001453A (es) 2021-04-12
IL280525B1 (en) 2024-07-01
AU2019319822A1 (en) 2021-03-18
KR102898177B1 (ko) 2025-12-10
EP3833389A1 (en) 2021-06-16
IL280525B2 (en) 2024-11-01
CA3106537A1 (en) 2020-02-13
MX428673B (es) 2025-11-13
CN112770775A (zh) 2021-05-07

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