KR102888393B1 - 신규한 염 및 결정 - Google Patents

신규한 염 및 결정

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Publication number
KR102888393B1
KR102888393B1 KR1020217000311A KR20217000311A KR102888393B1 KR 102888393 B1 KR102888393 B1 KR 102888393B1 KR 1020217000311 A KR1020217000311 A KR 1020217000311A KR 20217000311 A KR20217000311 A KR 20217000311A KR 102888393 B1 KR102888393 B1 KR 102888393B1
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KR
South Korea
Prior art keywords
iti
salt
delete delete
free base
toluenesulfonic acid
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020217000311A
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English (en)
Korean (ko)
Other versions
KR20210018440A (ko
Inventor
펑 리
Original Assignee
인트라-셀룰라 써래피스, 인코퍼레이티드.
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Application filed by 인트라-셀룰라 써래피스, 인코퍼레이티드. filed Critical 인트라-셀룰라 써래피스, 인코퍼레이티드.
Publication of KR20210018440A publication Critical patent/KR20210018440A/ko
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Publication of KR102888393B1 publication Critical patent/KR102888393B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020217000311A 2018-06-06 2019-06-06 신규한 염 및 결정 Active KR102888393B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862681534P 2018-06-06 2018-06-06
US62/681,534 2018-06-06
PCT/US2019/035845 WO2019236889A1 (en) 2018-06-06 2019-06-06 Novel salts and crystals

Publications (2)

Publication Number Publication Date
KR20210018440A KR20210018440A (ko) 2021-02-17
KR102888393B1 true KR102888393B1 (ko) 2025-11-18

Family

ID=68769581

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217000311A Active KR102888393B1 (ko) 2018-06-06 2019-06-06 신규한 염 및 결정

Country Status (11)

Country Link
US (2) US20200157100A1 (https=)
EP (1) EP3628007B1 (https=)
JP (1) JP7476115B2 (https=)
KR (1) KR102888393B1 (https=)
CN (1) CN112384218B (https=)
AU (1) AU2019280850C1 (https=)
BR (1) BR112020024885A2 (https=)
CA (1) CA3102848A1 (https=)
IL (2) IL321985A (https=)
MX (1) MX2020013116A (https=)
WO (1) WO2019236889A1 (https=)

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PL3497104T3 (pl) 2016-08-09 2022-02-21 Teva Pharmaceuticals International Gmbh Postacie w stanie stałym soli ditosylanowej lumateperonu
EP3525763B1 (en) 2016-10-12 2025-03-05 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
US11440911B2 (en) 2017-09-26 2022-09-13 Intra-Cellular Therapies, Inc. Salts and crystals
WO2019178484A1 (en) 2018-03-16 2019-09-19 Intra-Cellular Therapies, Inc. Novel methods
CA3240552A1 (en) * 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
BR112021003655A2 (pt) 2018-08-31 2021-05-18 Intra-Cellular Therapies, Inc. métodos novos
WO2021007245A1 (en) * 2019-07-07 2021-01-14 Intra-Cellular Therapies, Inc. Novel methods
US12478623B2 (en) 2019-09-25 2025-11-25 Intra-Cellular Therapies, Inc. Methods of treating central nervous system disorders comprising administering lumateperone and a nitric oxide donor
EP4072554A4 (en) 2019-12-11 2023-12-20 Intra-Cellular Therapies, Inc. ORGANIC CONNECTION
IL300886A (en) * 2020-09-04 2023-04-01 Intra Cellular Therapies Inc New salts, crystals and co-crystals
CN115120593A (zh) * 2021-03-26 2022-09-30 上海博志研新药物技术有限公司 卢美哌隆药用盐、制备方法、含其的药物组合物及应用
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
US20250352469A1 (en) 2024-05-16 2025-11-20 Intra-Cellular Therapies, Inc. Novel compositions, devices, and methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018031535A1 (en) * 2016-08-09 2018-02-15 Assia Chemical Industries Ltd. Solid state forms of lumateperone ditosylate salt

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Also Published As

Publication number Publication date
KR20210018440A (ko) 2021-02-17
MX2020013116A (es) 2021-05-12
IL279195B1 (en) 2025-08-01
CN112384218B (zh) 2024-04-26
WO2019236889A1 (en) 2019-12-12
JP7476115B2 (ja) 2024-04-30
IL321985A (en) 2025-09-01
US12195464B2 (en) 2025-01-14
EP3628007A4 (en) 2020-05-20
AU2019280850B2 (en) 2024-08-08
IL279195A (en) 2021-01-31
AU2019280850A1 (en) 2021-01-07
EP3628007B1 (en) 2023-05-03
JP2021527043A (ja) 2021-10-11
CN112384218A (zh) 2021-02-19
CA3102848A1 (en) 2019-12-12
IL279195B2 (en) 2025-12-01
EP3628007A1 (en) 2020-04-01
US20200157100A1 (en) 2020-05-21
US20220281867A1 (en) 2022-09-08
BR112020024885A2 (pt) 2021-03-09
AU2019280850C1 (en) 2025-02-13

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