KR102875260B1 - Kit- 및 pdgfra 매개성 질환을 치료하기 위한 피롤로트리아진 유도체 - Google Patents

Kit- 및 pdgfra 매개성 질환을 치료하기 위한 피롤로트리아진 유도체

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Publication number
KR102875260B1
KR102875260B1 KR1020217036868A KR20217036868A KR102875260B1 KR 102875260 B1 KR102875260 B1 KR 102875260B1 KR 1020217036868 A KR1020217036868 A KR 1020217036868A KR 20217036868 A KR20217036868 A KR 20217036868A KR 102875260 B1 KR102875260 B1 KR 102875260B1
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compound
mmol
pharmaceutically acceptable
solvate
acceptable salt
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Korean (ko)
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KR20220025704A (ko
Inventor
조셉 엘. 김
토마스 에이. 디닌
티모시 구지
Original Assignee
블루프린트 메디신즈 코포레이션
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=70416596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102875260(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020217036868A 2019-04-12 2020-04-08 Kit- 및 pdgfra 매개성 질환을 치료하기 위한 피롤로트리아진 유도체 Active KR102875260B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962833529P 2019-04-12 2019-04-12
US62/833,529 2019-04-12
US201962911016P 2019-10-04 2019-10-04
US62/911,016 2019-10-04
US201962930240P 2019-11-04 2019-11-04
US62/930,240 2019-11-04
PCT/US2020/027177 WO2020210293A1 (en) 2019-04-12 2020-04-08 Pyrrolotriazine derivatives for treating kit- and pdgfra-mediated diseases

Publications (2)

Publication Number Publication Date
KR20220025704A KR20220025704A (ko) 2022-03-03
KR102875260B1 true KR102875260B1 (ko) 2025-10-23

Family

ID=70416596

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217036868A Active KR102875260B1 (ko) 2019-04-12 2020-04-08 Kit- 및 pdgfra 매개성 질환을 치료하기 위한 피롤로트리아진 유도체

Country Status (33)

Country Link
US (3) US12552795B2 (enExample)
EP (2) EP4424312A3 (enExample)
JP (2) JP7600140B2 (enExample)
KR (1) KR102875260B1 (enExample)
CN (1) CN113939515B (enExample)
AU (1) AU2020272743B2 (enExample)
BR (1) BR112021020441A2 (enExample)
CA (1) CA3136802A1 (enExample)
CL (1) CL2021002656A1 (enExample)
CO (1) CO2021015113A2 (enExample)
DK (1) DK3953357T3 (enExample)
EC (1) ECSP21080096A (enExample)
ES (1) ES2980811T3 (enExample)
FI (1) FI3953357T3 (enExample)
HR (1) HRP20240702T1 (enExample)
HU (1) HUE067299T2 (enExample)
IL (1) IL287168B2 (enExample)
LT (1) LT3953357T (enExample)
MA (1) MA55604B1 (enExample)
MD (1) MD3953357T2 (enExample)
MX (1) MX2021012469A (enExample)
MY (1) MY209048A (enExample)
PE (1) PE20212331A1 (enExample)
PH (1) PH12021552568A1 (enExample)
PL (1) PL3953357T3 (enExample)
PT (1) PT3953357T (enExample)
RS (1) RS65644B1 (enExample)
SG (1) SG11202111244XA (enExample)
SI (1) SI3953357T1 (enExample)
SM (1) SMT202400229T1 (enExample)
TW (1) TWI857043B (enExample)
WO (1) WO2020210293A1 (enExample)
ZA (1) ZA202108104B (enExample)

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CN109970745B (zh) 2018-04-16 2020-12-08 深圳市塔吉瑞生物医药有限公司 取代的吡咯并三嗪类化合物及其药物组合物及其用途
SG11202111244XA (en) 2019-04-12 2021-11-29 Blueprint Medicines Corp Pyrrolotriazine derivatives for treating kit- and pdgfra-mediated diseases
CN117098760B (zh) * 2020-10-14 2026-04-14 缆图药品公司 用于治疗kit和pdgfra介导的疾病的组合物和方法
WO2022081626A1 (en) * 2020-10-14 2022-04-21 Blueprint Medicines Corporation Compositions and methods for treating kit-and pdgfra-mediated diseases
HU231413B1 (hu) 2021-02-26 2023-08-28 Egis Gyógyszergyár Zrt. Eljárás avapritinib és intermedierek előállítására
JP7763848B2 (ja) * 2021-03-03 2025-11-04 ブループリント メディシンズ コーポレイション Ｋｉｔ－およびｐｄｇｆｒａ－媒介性疾患を治療するための化合物を製造するための合成方法および中間生成物
WO2022192558A1 (en) 2021-03-10 2022-09-15 Blueprint Medicines Corporation Salt and solid forms of a kinase inhibitor
CN117794935A (zh) * 2021-03-10 2024-03-29 缆图药品公司 激酶抑制剂的盐和固体形式
CN113278023B (zh) * 2021-07-22 2021-10-15 上海睿跃生物科技有限公司 含氮杂环化合物及其制备方法和应用
US20250129067A1 (en) * 2021-11-08 2025-04-24 Progentos Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
WO2024171143A1 (en) 2023-02-17 2024-08-22 Assia Chemical Industries Ltd. Salts and solid forms of elenestinib

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US20260138986A1 (en) 2026-05-21
CN113939515A (zh) 2022-01-14
SMT202400229T1 (it) 2024-07-09
WO2020210293A1 (en) 2020-10-15
FI3953357T3 (fi) 2024-07-15
CL2021002656A1 (es) 2022-08-26
TWI857043B (zh) 2024-10-01
CA3136802A1 (en) 2020-10-15
HUE067299T2 (hu) 2024-10-28
MY209048A (en) 2025-06-18
EP3953357A1 (en) 2022-02-16
EP4424312A2 (en) 2024-09-04
US20220153748A1 (en) 2022-05-19
IL287168B1 (en) 2025-06-01
RS65644B1 (sr) 2024-07-31
AU2020272743A1 (en) 2021-11-11
HRP20240702T1 (hr) 2024-08-16
PE20212331A1 (es) 2021-12-14
PH12021552568A1 (en) 2022-07-04
TW202104231A (zh) 2021-02-01
CN113939515B (zh) 2024-06-18
IL287168B2 (en) 2025-10-01
ZA202108104B (en) 2024-02-28
MD3953357T2 (ro) 2024-09-30
MA55604B1 (fr) 2024-08-30
KR20220025704A (ko) 2022-03-03
JP2025029094A (ja) 2025-03-05
EP4424312A3 (en) 2025-01-08
BR112021020441A2 (pt) 2021-12-14
US10829493B2 (en) 2020-11-10
PL3953357T3 (pl) 2024-09-02
US20200325141A1 (en) 2020-10-15
US12552795B2 (en) 2026-02-17
MA55604A (fr) 2022-02-16
LT3953357T (lt) 2024-07-25
EP3953357B1 (en) 2024-04-17
SG11202111244XA (en) 2021-11-29
JP2022526850A (ja) 2022-05-26
DK3953357T3 (en) 2024-06-10
SI3953357T1 (sl) 2024-08-30
IL287168A (en) 2021-12-01
CO2021015113A2 (es) 2022-02-28
ES2980811T3 (es) 2024-10-03
JP7600140B2 (ja) 2024-12-16
AU2020272743B2 (en) 2025-10-16
ECSP21080096A (es) 2022-02-25
PT3953357T (pt) 2024-07-24
MX2021012469A (es) 2022-01-18

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