KR102786353B1 - 인간화 또는 키메라 cd3 항체 - Google Patents

인간화 또는 키메라 cd3 항체 Download PDF

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Publication number
KR102786353B1
KR102786353B1 KR1020187004157A KR20187004157A KR102786353B1 KR 102786353 B1 KR102786353 B1 KR 102786353B1 KR 1020187004157 A KR1020187004157 A KR 1020187004157A KR 20187004157 A KR20187004157 A KR 20187004157A KR 102786353 B1 KR102786353 B1 KR 102786353B1
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seq
set forth
antibody
cdr2
cdr1
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Korean (ko)
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KR20180030635A (ko
Inventor
릭 라데마케르
이실 알틴타스
파트릭 엥겔베르츠
야니너 스휘르만
파울 파런
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젠맵 에이/에스
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Priority claimed from PCT/EP2016/050296 external-priority patent/WO2016110576A1/en
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Publication of KR20180030635A publication Critical patent/KR20180030635A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020187004157A 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체 Active KR102786353B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257009196A KR20250048113A (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DKPA201500414 2015-07-15
DKPA201500413 2015-07-15
DKPA201500413 2015-07-15
DKPA201500414 2015-07-15
DKPA201500416 2015-07-16
DKPA201500416 2015-07-16
EPPCT/EP2016/050296 2016-01-08
PCT/EP2016/050296 WO2016110576A1 (en) 2015-01-08 2016-01-08 Bispecific antibodies against cd3 and cd20
PCT/EP2016/066845 WO2017009442A1 (en) 2015-07-15 2016-07-14 Humanized or chimeric cd3 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257009196A Division KR20250048113A (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체

Publications (2)

Publication Number Publication Date
KR20180030635A KR20180030635A (ko) 2018-03-23
KR102786353B1 true KR102786353B1 (ko) 2025-03-26

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KR1020187004157A Active KR102786353B1 (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체
KR1020257009196A Pending KR20250048113A (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체

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Country Link
US (4) US11359015B2 (https=)
EP (1) EP3322727B1 (https=)
JP (3) JP2018526981A (https=)
KR (2) KR102786353B1 (https=)
CN (3) CN108368172B (https=)
AU (2) AU2016293073B2 (https=)
BR (1) BR112018000696A2 (https=)
CA (1) CA2992380A1 (https=)
DK (1) DK3322727T3 (https=)
EA (1) EA201890305A1 (https=)
ES (1) ES3063317T3 (https=)
FI (1) FI3322727T3 (https=)
IL (2) IL256562B2 (https=)
MX (2) MX395317B (https=)
NZ (1) NZ739028A (https=)
PT (1) PT3322727T (https=)
UA (1) UA128057C2 (https=)
WO (1) WO2017009442A1 (https=)

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EP4007772A4 (en) * 2019-07-29 2023-11-29 The Administrators Of The Tulane Educational Fund ANTIBODIES TO CANDIDA AND USES THEREOF
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Publication number Publication date
AU2016293073B2 (en) 2022-12-22
DK3322727T3 (da) 2026-03-30
IL310467A (en) 2024-03-01
UA128057C2 (uk) 2024-03-27
US20230027394A1 (en) 2023-01-26
NZ778205A (en) 2025-05-02
CN108368172A (zh) 2018-08-03
JP7604351B2 (ja) 2024-12-23
NZ778208A (en) 2025-05-02
WO2017009442A1 (en) 2017-01-19
AU2016293073A1 (en) 2018-02-01
CN120842408A (zh) 2025-10-28
KR20180030635A (ko) 2018-03-23
US20220389101A1 (en) 2022-12-08
BR112018000696A2 (en) 2018-09-18
MX2018000347A (es) 2018-03-14
CN108368172B (zh) 2022-06-14
MX395317B (es) 2025-03-25
NZ739028A (en) 2023-05-26
CN114989302B (zh) 2025-08-05
FI3322727T3 (fi) 2026-03-17
PT3322727T (pt) 2026-03-16
IL256562A (en) 2018-02-28
AU2023201733A1 (en) 2023-07-13
ES3063317T3 (en) 2026-04-16
JP2018526981A (ja) 2018-09-20
US20190284278A1 (en) 2019-09-19
JP2022023862A (ja) 2022-02-08
EA201890305A1 (ru) 2018-07-31
CA2992380A1 (en) 2017-01-19
IL256562B1 (en) 2024-03-01
US11359015B2 (en) 2022-06-14
KR20250048113A (ko) 2025-04-07
IL256562B2 (en) 2024-07-01
EP3322727A1 (en) 2018-05-23
MX2022011002A (es) 2022-10-07
US20220380464A1 (en) 2022-12-01
CN114989302A (zh) 2022-09-02
EP3322727B1 (en) 2025-12-31
JP2025038049A (ja) 2025-03-18

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