CN108368172B - 人源化或嵌合cd3抗体 - Google Patents

人源化或嵌合cd3抗体 Download PDF

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Publication number
CN108368172B
CN108368172B CN201680054638.0A CN201680054638A CN108368172B CN 108368172 B CN108368172 B CN 108368172B CN 201680054638 A CN201680054638 A CN 201680054638A CN 108368172 B CN108368172 B CN 108368172B
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Prior art keywords
antibody
seq
cdr2
cdr1
cdr3 sequences
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Chinese (zh)
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CN108368172A (zh
Inventor
R.拉德马克
I.阿尔廷塔斯
P.恩格伯特斯
J.舒尔曼
P.帕伦
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Genmab AS
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Genmab AS
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Priority claimed from PCT/EP2016/050296 external-priority patent/WO2016110576A1/en
Application filed by Genmab AS filed Critical Genmab AS
Priority to CN202511003204.5A priority Critical patent/CN120842408A/zh
Priority to CN202210585379.1A priority patent/CN114989302B/zh
Publication of CN108368172A publication Critical patent/CN108368172A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680054638.0A 2015-07-15 2016-07-14 人源化或嵌合cd3抗体 Active CN108368172B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202511003204.5A CN120842408A (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN202210585379.1A CN114989302B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DKPA201500414 2015-07-15
DKPA201500413 2015-07-15
DKPA201500413 2015-07-15
DKPA201500414 2015-07-15
DKPA201500416 2015-07-16
DKPA201500416 2015-07-16
EPPCT/EP2016/050296 2016-01-08
PCT/EP2016/050296 WO2016110576A1 (en) 2015-01-08 2016-01-08 Bispecific antibodies against cd3 and cd20
PCT/EP2016/066845 WO2017009442A1 (en) 2015-07-15 2016-07-14 Humanized or chimeric cd3 antibodies

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202511003204.5A Division CN120842408A (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN202210585379.1A Division CN114989302B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Publications (2)

Publication Number Publication Date
CN108368172A CN108368172A (zh) 2018-08-03
CN108368172B true CN108368172B (zh) 2022-06-14

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CN201680054638.0A Active CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN202210585379.1A Active CN114989302B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN202511003204.5A Pending CN120842408A (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

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CN202210585379.1A Active CN114989302B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN202511003204.5A Pending CN120842408A (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

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US (4) US11359015B2 (https=)
EP (1) EP3322727B1 (https=)
JP (3) JP2018526981A (https=)
KR (2) KR102786353B1 (https=)
CN (3) CN108368172B (https=)
AU (2) AU2016293073B2 (https=)
BR (1) BR112018000696A2 (https=)
CA (1) CA2992380A1 (https=)
DK (1) DK3322727T3 (https=)
EA (1) EA201890305A1 (https=)
ES (1) ES3063317T3 (https=)
FI (1) FI3322727T3 (https=)
IL (2) IL256562B2 (https=)
MX (2) MX395317B (https=)
NZ (1) NZ739028A (https=)
PT (1) PT3322727T (https=)
UA (1) UA128057C2 (https=)
WO (1) WO2017009442A1 (https=)

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SG11202000198QA (en) 2017-08-04 2020-02-27 Genmab As Binding agents binding to pd-l1 and cd137 and use thereof
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US11203646B2 (en) * 2018-03-14 2021-12-21 Novimmune Sa Anti-CD3 epsilon antibodies and methods of use thereof
WO2020047176A1 (en) * 2018-08-28 2020-03-05 Ambrx, Inc. Anti-cd3 antibody folate bioconjugates and their uses
KR20220035369A (ko) * 2019-06-07 2022-03-22 아디맵 엘엘씨 고 친화도 항-cd3 항체, 및 이의 생성 및 사용 방법
EP4007772A4 (en) * 2019-07-29 2023-11-29 The Administrators Of The Tulane Educational Fund ANTIBODIES TO CANDIDA AND USES THEREOF
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AU2016293073B2 (en) 2022-12-22
DK3322727T3 (da) 2026-03-30
IL310467A (en) 2024-03-01
KR102786353B1 (ko) 2025-03-26
UA128057C2 (uk) 2024-03-27
US20230027394A1 (en) 2023-01-26
NZ778205A (en) 2025-05-02
CN108368172A (zh) 2018-08-03
JP7604351B2 (ja) 2024-12-23
NZ778208A (en) 2025-05-02
WO2017009442A1 (en) 2017-01-19
AU2016293073A1 (en) 2018-02-01
CN120842408A (zh) 2025-10-28
KR20180030635A (ko) 2018-03-23
US20220389101A1 (en) 2022-12-08
BR112018000696A2 (en) 2018-09-18
MX2018000347A (es) 2018-03-14
MX395317B (es) 2025-03-25
NZ739028A (en) 2023-05-26
CN114989302B (zh) 2025-08-05
FI3322727T3 (fi) 2026-03-17
PT3322727T (pt) 2026-03-16
IL256562A (en) 2018-02-28
AU2023201733A1 (en) 2023-07-13
ES3063317T3 (en) 2026-04-16
JP2018526981A (ja) 2018-09-20
US20190284278A1 (en) 2019-09-19
JP2022023862A (ja) 2022-02-08
EA201890305A1 (ru) 2018-07-31
CA2992380A1 (en) 2017-01-19
IL256562B1 (en) 2024-03-01
US11359015B2 (en) 2022-06-14
KR20250048113A (ko) 2025-04-07
IL256562B2 (en) 2024-07-01
EP3322727A1 (en) 2018-05-23
MX2022011002A (es) 2022-10-07
US20220380464A1 (en) 2022-12-01
CN114989302A (zh) 2022-09-02
EP3322727B1 (en) 2025-12-31
JP2025038049A (ja) 2025-03-18

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