KR102775437B1 - 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커 - Google Patents

접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커 Download PDF

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KR102775437B1
KR102775437B1 KR1020227038426A KR20227038426A KR102775437B1 KR 102775437 B1 KR102775437 B1 KR 102775437B1 KR 1020227038426 A KR1020227038426 A KR 1020227038426A KR 20227038426 A KR20227038426 A KR 20227038426A KR 102775437 B1 KR102775437 B1 KR 102775437B1
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metabolite
acid
biomarker
diol
sulfate
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KR20220154245A (ko
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다니엘 제이. 섹스톤
말리니 비스와나탄
라이언 파우셋
트립티 가우르
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다케다 파머수티컬 컴패니 리미티드
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743Steroid hormones
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406Neurotransmitters
    • G01N33/942Serotonin, i.e. 5-hydroxy-tryptamine
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/22Haematology
    • G01N2800/224Haemostasis or coagulation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/7095Inflammation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
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  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020227038426A 2016-09-16 2017-09-15 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커 Active KR102775437B1 (ko)

Priority Applications (1)

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KR1020257006143A KR20250030022A (ko) 2016-09-16 2017-09-15 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662395770P 2016-09-16 2016-09-16
US62/395,770 2016-09-16
US201762518367P 2017-06-12 2017-06-12
US62/518,367 2017-06-12
KR1020197010802A KR102464380B1 (ko) 2016-09-16 2017-09-15 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커
PCT/US2017/051755 WO2018053247A1 (en) 2016-09-16 2017-09-15 Metabolite biomarkers for diseases associated with the contact activation system

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KR102775437B1 true KR102775437B1 (ko) 2025-03-05

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KR1020197010802A Active KR102464380B1 (ko) 2016-09-16 2017-09-15 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커
KR1020257006143A Pending KR20250030022A (ko) 2016-09-16 2017-09-15 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커

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KR1020257006143A Pending KR20250030022A (ko) 2016-09-16 2017-09-15 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커

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US (3) US11340237B2 (enExample)
EP (1) EP3513197A1 (enExample)
JP (4) JP7225090B2 (enExample)
KR (3) KR102775437B1 (enExample)
CN (2) CN109716137B (enExample)
AU (2) AU2017325986B2 (enExample)
BR (1) BR112019005167A2 (enExample)
CA (1) CA3037157A1 (enExample)
CO (1) CO2019002607A2 (enExample)
IL (2) IL314752A (enExample)
MX (2) MX2019002918A (enExample)
WO (1) WO2018053247A1 (enExample)

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KR20220154245A (ko) 2022-11-21
KR20190053914A (ko) 2019-05-20
JP7225090B2 (ja) 2023-02-20
CN109716137B (zh) 2023-07-21
CN117169508A (zh) 2023-12-05
CO2019002607A2 (es) 2019-03-29
EP3513197A1 (en) 2019-07-24
US12188948B2 (en) 2025-01-07
BR112019005167A2 (pt) 2019-07-02
JP2024059990A (ja) 2024-05-01
JP2025124816A (ja) 2025-08-26
JP7451791B2 (ja) 2024-03-18
IL314752A (en) 2024-10-01
JP7692508B2 (ja) 2025-06-13
KR102464380B1 (ko) 2022-11-07
AU2024200561A1 (en) 2024-02-15
MX2019002918A (es) 2019-07-18
MX2024004195A (es) 2024-04-23
KR20250030022A (ko) 2025-03-05
AU2017325986A1 (en) 2019-04-04
US11340237B2 (en) 2022-05-24
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CA3037157A1 (en) 2018-03-22
IL265199A (en) 2019-05-30
US20190361036A1 (en) 2019-11-28
WO2018053247A1 (en) 2018-03-22
NZ751481A (en) 2024-02-23
AU2017325986B2 (en) 2023-12-14
CN109716137A (zh) 2019-05-03
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