KR102775366B1 - 인간화 tmprss 유전자를 갖는 설치류 - Google Patents

인간화 tmprss 유전자를 갖는 설치류 Download PDF

Info

Publication number
KR102775366B1
KR102775366B1 KR1020237003004A KR20237003004A KR102775366B1 KR 102775366 B1 KR102775366 B1 KR 102775366B1 KR 1020237003004 A KR1020237003004 A KR 1020237003004A KR 20237003004 A KR20237003004 A KR 20237003004A KR 102775366 B1 KR102775366 B1 KR 102775366B1
Authority
KR
South Korea
Prior art keywords
gene
human
humanized
delete delete
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020237003004A
Other languages
English (en)
Korean (ko)
Other versions
KR20230021759A (ko
Inventor
은감보 리사 퍼셀
알렉산더 오 무지카
야준 탕
Original Assignee
리제너론 파마슈티칼스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리제너론 파마슈티칼스 인코포레이티드 filed Critical 리제너론 파마슈티칼스 인코포레이티드
Publication of KR20230021759A publication Critical patent/KR20230021759A/ko
Application granted granted Critical
Publication of KR102775366B1 publication Critical patent/KR102775366B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020237003004A 2016-02-29 2017-02-27 인간화 tmprss 유전자를 갖는 설치류 Active KR102775366B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662301023P 2016-02-29 2016-02-29
US62/301,023 2016-02-29
KR1020187026552A KR102493894B1 (ko) 2016-02-29 2017-02-27 인간화 tmprss 유전자를 갖는 설치류
PCT/US2017/019574 WO2017151453A1 (en) 2016-02-29 2017-02-27 Rodents having a humanized tmprss gene

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187026552A Division KR102493894B1 (ko) 2016-02-29 2017-02-27 인간화 tmprss 유전자를 갖는 설치류

Publications (2)

Publication Number Publication Date
KR20230021759A KR20230021759A (ko) 2023-02-14
KR102775366B1 true KR102775366B1 (ko) 2025-03-05

Family

ID=58264641

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237003004A Active KR102775366B1 (ko) 2016-02-29 2017-02-27 인간화 tmprss 유전자를 갖는 설치류
KR1020187026552A Active KR102493894B1 (ko) 2016-02-29 2017-02-27 인간화 tmprss 유전자를 갖는 설치류

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020187026552A Active KR102493894B1 (ko) 2016-02-29 2017-02-27 인간화 tmprss 유전자를 갖는 설치류

Country Status (14)

Country Link
US (5) US10070632B2 (enExample)
EP (2) EP3422845B1 (enExample)
JP (1) JP6980674B2 (enExample)
KR (2) KR102775366B1 (enExample)
CN (1) CN109068621B (enExample)
AU (1) AU2017228293B2 (enExample)
CA (1) CA3014645C (enExample)
DK (1) DK3422845T3 (enExample)
ES (1) ES2886958T3 (enExample)
IL (1) IL261139B (enExample)
PT (1) PT3422845T (enExample)
RU (1) RU2749715C2 (enExample)
SG (2) SG10202001578RA (enExample)
WO (1) WO2017151453A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10202001578RA (en) * 2016-02-29 2020-04-29 Regeneron Pharma Rodents having a humanized tmprss gene
CA3071712C (en) * 2017-09-29 2023-02-14 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus and methods of use
HRP20210876T1 (hr) 2018-01-26 2021-07-09 Regeneron Pharmaceuticals, Inc. Anti-tmprss2 antitijela i fragmenti koji vezuju antigen
SG11202011284RA (en) 2018-07-16 2020-12-30 Regeneron Pharma Non-human animal models of ditra disease and uses thereof
KR20210116480A (ko) * 2019-01-17 2021-09-27 리제너론 파마슈티칼스 인코포레이티드 기분 장애의 설치류 모델
CN115427457A (zh) 2020-02-10 2022-12-02 瑞泽恩制药公司 抗tmprss2抗体和抗原结合片段
CN115161326B (zh) * 2021-06-21 2024-09-24 百奥赛图(北京)医药科技股份有限公司 Sost基因人源化非人动物及其构建方法和应用
WO2023122506A1 (en) 2021-12-20 2023-06-29 Regeneron Pharmaceuticals, Inc. Non-human animals comprising humanized ace2 and tmprss loci

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015077071A1 (en) 2013-11-19 2015-05-28 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized b-cell activating factor gene
WO2015171861A1 (en) 2014-05-07 2015-11-12 Regeneron Pharmaceuticals, Inc. Humanized il-4 and il-4r alpha animals
KR101693243B1 (ko) 2016-06-15 2017-01-05 재단법인 한국파스퇴르연구소 인플루엔자 바이러스의 복제에 관여하는 신규 인간 유전자 및 이의 용도
JP2017536126A (ja) 2014-11-24 2017-12-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｃｄ３複合体を発現する非ヒト動物

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002065266A (ja) * 2000-08-28 2002-03-05 Teijin Ltd 気道特異的トリプシン様酵素およびその利用法
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
AU2002359781A1 (en) * 2001-12-20 2003-07-09 The Regents Of The University Of California Triple transgenic mouse model of alzheimer's disease
US20050026255A1 (en) * 2002-06-25 2005-02-03 Morser John Michael Corin, a serine protease
US20040132156A1 (en) * 2002-10-04 2004-07-08 Schering Aktiengesellschaft Modified hepsin molecules having a substitute activation sequence and uses thereof
CA2527361A1 (en) * 2003-06-11 2004-12-23 Schering Aktiengesellschaft Novel modified corin molecules having substitute activation sequences and uses thereof
US7491865B2 (en) * 2004-08-19 2009-02-17 Fred Hutchinson Cancer Research Center Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene
ES2667169T3 (es) 2004-10-19 2018-05-09 Regeneron Pharmaceuticals, Inc. Método para generar un animal no humano homocigótico para una modificación genética
PT2019837E (pt) * 2006-05-23 2011-07-05 Irm Llc Compostos e composições como inibidores das proteases activadoras de canal
GB0821624D0 (en) * 2008-11-26 2008-12-31 Eisai London Res Lab Ltd Assay
JP5851842B2 (ja) * 2009-01-12 2016-02-03 サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. 改変した抗体組成物、それを作製および使用する方法
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
ES2700852T3 (es) 2009-10-06 2019-02-19 Regeneron Pharma Ratones modificados genéticamente e injerto
CN105861553B (zh) * 2011-02-15 2020-08-14 再生元制药公司 人源化m-csf小鼠
HUE035652T2 (en) 2011-10-28 2018-05-28 Regeneron Pharma Genetically modified major histocompatibility complex mice
DK2663575T3 (en) 2011-10-28 2014-12-15 Regeneron Pharma HUMANIZED IL-6 and IL-6 receptor
KR102113108B1 (ko) 2011-10-28 2020-05-20 리제너론 파아마슈티컬스, 인크. 키메라 주요 조직적합성 복합체 （ｍｈｃ） 제ｉｉ부류 분자들을 발현하는 유전자전이 마우스
JP6446355B2 (ja) 2012-04-16 2018-12-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． セリンプロテアーゼ阻害剤を投与することによるインフルエンザウイルス感染を処置又は予防する方法
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
AU2013278075B2 (en) * 2012-06-22 2018-05-17 Cytomx Therapeutics, Inc. Anti-jagged 1/Jagged 2 cross-reactive antibodies, activatable anti-Jagged antibodies and methods of use thereof
IL307969B1 (en) 2012-09-07 2025-10-01 Regeneron Pharma Genetically modified non-human animals and methods of using them
CA2887706C (en) 2012-11-05 2022-08-02 Regeneron Pharmaceuticals Genetically modified non-human animals and methods of use thereof
WO2014130671A1 (en) 2013-02-20 2014-08-28 Regeneron Pharmaceuticals, Inc. Mice expressing humanized t-cell co-receptors
CN109913495B (zh) 2013-02-20 2022-11-25 瑞泽恩制药公司 大鼠的遗传修饰
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
KR102211267B1 (ko) 2013-02-22 2021-02-04 리제너론 파아마슈티컬스, 인크. 사람화된 주요 조직적합성 복합체를 발현하는 마우스
SI2986729T1 (sl) 2013-04-16 2019-02-28 Regeneron Pharmaceuticals, Inc. Ciljana sprememba genoma podgane
CA2913732A1 (en) 2013-06-04 2014-12-11 Cytomx Therapeutics, Inc. Compositions and methods for conjugating activatable antibodies
RU2018136614A (ru) 2013-09-23 2018-11-27 Регенерон Фармасьютикалс, Инк. Отличные от человека животные с гуманизированным геном сигнального регуляторного белка
TR201904342T4 (tr) 2013-10-15 2019-05-21 Regeneron Pharma Hümani̇ze il-15 hayvanlar
AU2014353347B2 (en) 2013-11-19 2020-07-02 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized a proliferation-inducing ligand gene
ES2794942T3 (es) 2014-04-08 2020-11-19 Regeneron Pharma Animales no humanos que tienen receptores Fc-gamma humanizados
DK3145307T3 (en) 2014-05-19 2019-04-15 Regeneron Pharma RE-MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO
SG11201609638RA (en) 2014-06-19 2016-12-29 Regeneron Pharma Non-human animals having a humanized programmed cell death 1 gene
DK3466255T3 (da) 2014-12-05 2021-05-03 Regeneron Pharma Ikke-humane dyr med en humaniseret klynge af differentiering af 47-gen
ES2841353T3 (es) 2014-12-09 2021-07-08 Regeneron Pharma Animales no humanos que tienen un gen del grupo de diferenciación 274 humanizado
AU2016246698B2 (en) 2015-04-06 2022-06-02 Regeneron Pharmaceuticals, Inc. Humanized T cell mediated immune responses in non-human animals
HUE054612T2 (hu) 2015-11-20 2021-09-28 Regeneron Pharma Humanizált limfocitaaktiváló gén 3-t tartalmazó nem-humán állatok
SG10202001578RA (en) 2016-02-29 2020-04-29 Regeneron Pharma Rodents having a humanized tmprss gene

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015077071A1 (en) 2013-11-19 2015-05-28 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized b-cell activating factor gene
WO2015171861A1 (en) 2014-05-07 2015-11-12 Regeneron Pharmaceuticals, Inc. Humanized il-4 and il-4r alpha animals
JP2017536126A (ja) 2014-11-24 2017-12-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｃｄ３複合体を発現する非ヒト動物
KR101693243B1 (ko) 2016-06-15 2017-01-05 재단법인 한국파스퇴르연구소 인플루엔자 바이러스의 복제에 관여하는 신규 인간 유전자 및 이의 용도

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J Virol. vol.84 no.11 pp.5605-5614 2010.
N Kuhn, Studies on the host response to influenza A virus infections in mouse knock-out mutants, 박사학위 University of Veterinary Medicine Hannover(2015.12.31)
Yu Sun, "Characterization of the TMPRSS2 Protease as a Modulator of Prostate Cancer Metastasis"(2009.03.31.)

Also Published As

Publication number Publication date
KR20230021759A (ko) 2023-02-14
RU2018131152A3 (enExample) 2020-07-13
US20180332831A1 (en) 2018-11-22
CA3014645C (en) 2022-10-25
US11910787B2 (en) 2024-02-27
RU2749715C2 (ru) 2021-06-16
EP3422845B1 (en) 2021-06-02
JP2019511918A (ja) 2019-05-09
AU2017228293A1 (en) 2018-08-23
EP3422845A1 (en) 2019-01-09
KR102493894B1 (ko) 2023-01-31
AU2017228293B2 (en) 2023-05-25
US20170245482A1 (en) 2017-08-31
US20170290308A1 (en) 2017-10-12
PT3422845T (pt) 2021-08-26
ES2886958T3 (es) 2021-12-21
WO2017151453A1 (en) 2017-09-08
SG11201807038UA (en) 2018-09-27
EP3895529A1 (en) 2021-10-20
US10070632B2 (en) 2018-09-11
JP6980674B2 (ja) 2021-12-15
US10070631B2 (en) 2018-09-11
CA3014645A1 (en) 2017-09-08
RU2018131152A (ru) 2020-04-01
US20240147971A1 (en) 2024-05-09
CN109068621A (zh) 2018-12-21
IL261139B (en) 2022-04-01
SG10202001578RA (en) 2020-04-29
CN109068621B (zh) 2021-07-20
DK3422845T3 (da) 2021-08-30
US20210068377A1 (en) 2021-03-11
US10863729B2 (en) 2020-12-15
IL261139A (en) 2018-10-31
KR20180117122A (ko) 2018-10-26

Similar Documents

Publication Publication Date Title
KR102775366B1 (ko) 인간화 tmprss 유전자를 갖는 설치류
US20250041457A1 (en) Use of adeno-associated viral vectors to correct gene defects/ express proteins in hair cells and supporting cells in the inner ear
AU2019360182B2 (en) Methods for targeted insertion of DNA in genes
KR102046668B1 (ko) 암 대상자의 예후를 결정하기 위한 방법 및 핵산
KR20150027793A (ko) 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물
KR20180093902A (ko) 태아와 임신 여성간에 상이하게 메틸화된 디엔에이 영역을 이용한 태아 염색체 이수성의 검출
KR20120099363A (ko) 탯줄 혈액으로부터의 유도 만능 줄기 세포의 생성
KR20170086027A (ko) 신경발달 장애에서의 행동을 개선시키기 위한 박테리아를 포함하는 조성물 및 방법
AU2018282072B2 (en) B4GALT1 variants and uses thereof
AU2016325030A1 (en) Novel biomarkers and methods of treating cancer
KR102661616B1 (ko) Gpr156 변이체 및 이들의 용도
RU2744831C2 (ru) Не относящееся к человеку животное, у которого проявляется снижение функции верхних и нижних моторных нейронов и чувственного восприятия
CN114080454A (zh) 核酸的随机化构型靶向整合
US20040171003A1 (en) Cancer-associated genes
KR20230124973A (ko) 인간화 tslp 유전자, 인간화 tslp 수용체 유전자, 및/또는인간화 il7ra 유전자를 갖는 비인간 동물
US20040197777A1 (en) Polymorphisms of the OCTN1 and OCTN2 cation transporters associated with inflammatory bowel disorders
JP2003259875A (ja) ヒト遺伝子の一塩基多型（４）
US20020142381A1 (en) Isolated nucleic acid molecules encoding human transporter proteins, and uses thereof
HK40061622A (en) Randomized configuration targeted integration of nucleic acids
JP2003116575A (ja) 新規遺伝子及びそれにコードされる蛋白質
JP2003180359A (ja) 新規遺伝子及びそれにコードされる蛋白質
JP2002345492A (ja) 新規遺伝子及びそれにコードされる蛋白質
CA2439155A1 (en) Isolated human tumor supressor proteins, nucleic acid molecules encoding these human tumor supressor proteins, and uses thereof
JP2003135081A (ja) 新規遺伝子及びそれにコードされる蛋白質
JP2003245081A (ja) 新規遺伝子及びそれにコードされる蛋白質

Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20230126

Application number text: 1020187026552

Filing date: 20180913

PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20230126

Comment text: Request for Examination of Application

PG1501 Laying open of application
E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20241125

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20250226

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20250227

End annual number: 3

Start annual number: 1

PG1601 Publication of registration