KR102774146B1 - 인간 보체 인자 c2b 에 대한 항체 및 이의 사용방법 - Google Patents

인간 보체 인자 c2b 에 대한 항체 및 이의 사용방법 Download PDF

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KR102774146B1
KR102774146B1 KR1020217021353A KR20217021353A KR102774146B1 KR 102774146 B1 KR102774146 B1 KR 102774146B1 KR 1020217021353 A KR1020217021353 A KR 1020217021353A KR 20217021353 A KR20217021353 A KR 20217021353A KR 102774146 B1 KR102774146 B1 KR 102774146B1
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크리스토프 블란체토트
한스 드 하르트
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아르제넥스 비브이
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/106Plasmid DNA for vertebrates
    • C12N2800/107Plasmid DNA for vertebrates for mammalian

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Devices For Post-Treatments, Processing, Supply, Discharge, And Other Processes (AREA)
KR1020217021353A 2018-12-13 2019-12-13 인간 보체 인자 c2b 에 대한 항체 및 이의 사용방법 Active KR102774146B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257005663A KR20250030005A (ko) 2018-12-13 2019-12-13 인간 보체 인자 c2b 에 대한 항체 및 이의 사용방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779102P 2018-12-13 2018-12-13
US62/779,102 2018-12-13
PCT/IB2019/060802 WO2020121282A1 (en) 2018-12-13 2019-12-13 Antibodies to human complement factor c2b and methods of use

Related Child Applications (1)

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KR1020257005663A Division KR20250030005A (ko) 2018-12-13 2019-12-13 인간 보체 인자 c2b 에 대한 항체 및 이의 사용방법

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KR20210100688A KR20210100688A (ko) 2021-08-17
KR102774146B1 true KR102774146B1 (ko) 2025-02-26

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KR1020217021353A Active KR102774146B1 (ko) 2018-12-13 2019-12-13 인간 보체 인자 c2b 에 대한 항체 및 이의 사용방법
KR1020257005663A Pending KR20250030005A (ko) 2018-12-13 2019-12-13 인간 보체 인자 c2b 에 대한 항체 및 이의 사용방법

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US (4) US11161900B2 (enExample)
EP (2) EP3893924B1 (enExample)
JP (3) JP7110491B2 (enExample)
KR (2) KR102774146B1 (enExample)
CN (2) CN119371526A (enExample)
AU (3) AU2019397614B2 (enExample)
BR (1) BR112021011107A2 (enExample)
CA (1) CA3119655A1 (enExample)
DK (1) DK3893924T3 (enExample)
EA (1) EA202191658A1 (enExample)
ES (1) ES2991894T3 (enExample)
FI (1) FI3893924T3 (enExample)
HU (1) HUE068993T2 (enExample)
IL (2) IL283916B2 (enExample)
LT (1) LT3893924T (enExample)
MX (2) MX2021006864A (enExample)
PL (1) PL3893924T3 (enExample)
PT (1) PT3893924T (enExample)
SG (1) SG11202105195PA (enExample)
WO (1) WO2020121282A1 (enExample)

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US11161900B2 (en) * 2018-12-13 2021-11-02 Argenx Bvba Antibodies that specifically bind to human complement factor C2b
GB2584105B (en) * 2019-05-21 2023-08-02 Argenx Bvba Methods of treating neuropathy
GB202407051D0 (en) 2024-05-17 2024-07-03 argenx BV Methods of treating osteoarthritis pain
WO2025257157A1 (en) 2024-06-10 2025-12-18 argenx BV Treatment or prevention of ischemia reperfusion injury in organ tranplantation

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WO2014189378A1 (en) 2013-05-23 2014-11-27 Broteio Pharma B.V. Binding molecules that bind human complement factor c2 and uses thereof

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Publication number Publication date
IL283916A (en) 2021-07-29
CN113260375B (zh) 2024-10-01
KR20250030005A (ko) 2025-03-05
FI3893924T3 (fi) 2024-10-04
JP7110491B2 (ja) 2022-08-01
US20220267424A1 (en) 2022-08-25
US20240002484A1 (en) 2024-01-04
EA202191658A1 (ru) 2021-11-03
DK3893924T3 (da) 2024-11-04
AU2022287637B2 (en) 2025-07-17
US20220119509A1 (en) 2022-04-21
CN119371526A (zh) 2025-01-28
JP2022512223A (ja) 2022-02-02
ES2991894T3 (es) 2024-12-05
AU2019397614B2 (en) 2022-09-15
EP3893924A1 (en) 2021-10-20
JP7611191B2 (ja) 2025-01-09
LT3893924T (lt) 2024-10-10
NZ776117A (en) 2024-07-26
PT3893924T (pt) 2024-10-09
PL3893924T3 (pl) 2025-01-13
AU2025252632A1 (en) 2025-11-06
BR112021011107A2 (pt) 2021-12-14
MX2025010337A (es) 2025-10-01
WO2020121282A1 (en) 2020-06-18
AU2019397614A1 (en) 2021-06-03
CN113260375A (zh) 2021-08-13
IL283916B1 (en) 2025-05-01
CA3119655A1 (en) 2020-06-18
AU2022287637A1 (en) 2023-02-02
EP4375297A2 (en) 2024-05-29
JP2024160274A (ja) 2024-11-13
SG11202105195PA (en) 2021-06-29
EP3893924B1 (en) 2024-08-21
JP2022160479A (ja) 2022-10-19
US11591386B2 (en) 2023-02-28
IL283916B2 (en) 2025-09-01
EP4375297A3 (en) 2024-10-30
MX2021006864A (es) 2021-07-02
IL319975A (en) 2025-05-01
HUE068993T2 (hu) 2025-02-28
US11708403B2 (en) 2023-07-25
KR20210100688A (ko) 2021-08-17
US20200239554A1 (en) 2020-07-30
US11161900B2 (en) 2021-11-02

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