AU2019397614B2 - Antibodies to human complement factor C2b and methods of use - Google Patents

Antibodies to human complement factor C2b and methods of use Download PDF

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Publication number
AU2019397614B2
AU2019397614B2 AU2019397614A AU2019397614A AU2019397614B2 AU 2019397614 B2 AU2019397614 B2 AU 2019397614B2 AU 2019397614 A AU2019397614 A AU 2019397614A AU 2019397614 A AU2019397614 A AU 2019397614A AU 2019397614 B2 AU2019397614 B2 AU 2019397614B2
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AU2019397614A1 (en
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Christophe Blanchetot
Hans De Haard
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ArgenX BVBA
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Priority to AU2025252632A priority patent/AU2025252632A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Devices For Post-Treatments, Processing, Supply, Discharge, And Other Processes (AREA)
AU2019397614A 2018-12-13 2019-12-13 Antibodies to human complement factor C2b and methods of use Active AU2019397614B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022287637A AU2022287637B2 (en) 2018-12-13 2022-12-15 Antibodies to human complement factor C2b and methods of use
AU2025252632A AU2025252632A1 (en) 2018-12-13 2025-10-17 Antibodies to human complement factor C2b and methods of use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779102P 2018-12-13 2018-12-13
US62/779,102 2018-12-13
PCT/IB2019/060802 WO2020121282A1 (en) 2018-12-13 2019-12-13 Antibodies to human complement factor c2b and methods of use

Related Child Applications (1)

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AU2022287637A Division AU2022287637B2 (en) 2018-12-13 2022-12-15 Antibodies to human complement factor C2b and methods of use

Publications (2)

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AU2019397614A1 AU2019397614A1 (en) 2021-06-03
AU2019397614B2 true AU2019397614B2 (en) 2022-09-15

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AU2019397614A Active AU2019397614B2 (en) 2018-12-13 2019-12-13 Antibodies to human complement factor C2b and methods of use
AU2022287637A Active AU2022287637B2 (en) 2018-12-13 2022-12-15 Antibodies to human complement factor C2b and methods of use
AU2025252632A Pending AU2025252632A1 (en) 2018-12-13 2025-10-17 Antibodies to human complement factor C2b and methods of use

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AU2025252632A Pending AU2025252632A1 (en) 2018-12-13 2025-10-17 Antibodies to human complement factor C2b and methods of use

Country Status (20)

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US (4) US11161900B2 (enExample)
EP (2) EP3893924B1 (enExample)
JP (3) JP7110491B2 (enExample)
KR (2) KR102774146B1 (enExample)
CN (2) CN119371526A (enExample)
AU (3) AU2019397614B2 (enExample)
BR (1) BR112021011107A2 (enExample)
CA (1) CA3119655A1 (enExample)
DK (1) DK3893924T3 (enExample)
EA (1) EA202191658A1 (enExample)
ES (1) ES2991894T3 (enExample)
FI (1) FI3893924T3 (enExample)
HU (1) HUE068993T2 (enExample)
IL (2) IL283916B2 (enExample)
LT (1) LT3893924T (enExample)
MX (2) MX2021006864A (enExample)
PL (1) PL3893924T3 (enExample)
PT (1) PT3893924T (enExample)
SG (1) SG11202105195PA (enExample)
WO (1) WO2020121282A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11161900B2 (en) * 2018-12-13 2021-11-02 Argenx Bvba Antibodies that specifically bind to human complement factor C2b
GB2584105B (en) * 2019-05-21 2023-08-02 Argenx Bvba Methods of treating neuropathy
GB202407051D0 (en) 2024-05-17 2024-07-03 argenx BV Methods of treating osteoarthritis pain
WO2025257157A1 (en) 2024-06-10 2025-12-18 argenx BV Treatment or prevention of ischemia reperfusion injury in organ tranplantation

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WO2014189378A1 (en) * 2013-05-23 2014-11-27 Broteio Pharma B.V. Binding molecules that bind human complement factor c2 and uses thereof

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US8501705B2 (en) 2003-09-11 2013-08-06 The Board Of Regents Of The University Of Texas System Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
US8163881B2 (en) 2005-05-31 2012-04-24 The Board Of Regents Of The University Of Texas System Immunoglobulin molecules with improved characteristics
EP2010214A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
AU2007257692B2 (en) 2006-06-12 2013-11-14 Aptevo Research And Development Llc Single-chain multivalent binding proteins with effector function
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Also Published As

Publication number Publication date
IL283916A (en) 2021-07-29
CN113260375B (zh) 2024-10-01
KR20250030005A (ko) 2025-03-05
FI3893924T3 (fi) 2024-10-04
JP7110491B2 (ja) 2022-08-01
US20220267424A1 (en) 2022-08-25
US20240002484A1 (en) 2024-01-04
EA202191658A1 (ru) 2021-11-03
DK3893924T3 (da) 2024-11-04
AU2022287637B2 (en) 2025-07-17
US20220119509A1 (en) 2022-04-21
CN119371526A (zh) 2025-01-28
JP2022512223A (ja) 2022-02-02
ES2991894T3 (es) 2024-12-05
EP3893924A1 (en) 2021-10-20
JP7611191B2 (ja) 2025-01-09
LT3893924T (lt) 2024-10-10
NZ776117A (en) 2024-07-26
PT3893924T (pt) 2024-10-09
PL3893924T3 (pl) 2025-01-13
AU2025252632A1 (en) 2025-11-06
BR112021011107A2 (pt) 2021-12-14
MX2025010337A (es) 2025-10-01
WO2020121282A1 (en) 2020-06-18
AU2019397614A1 (en) 2021-06-03
CN113260375A (zh) 2021-08-13
IL283916B1 (en) 2025-05-01
CA3119655A1 (en) 2020-06-18
AU2022287637A1 (en) 2023-02-02
EP4375297A2 (en) 2024-05-29
JP2024160274A (ja) 2024-11-13
SG11202105195PA (en) 2021-06-29
EP3893924B1 (en) 2024-08-21
JP2022160479A (ja) 2022-10-19
US11591386B2 (en) 2023-02-28
IL283916B2 (en) 2025-09-01
EP4375297A3 (en) 2024-10-30
KR102774146B1 (ko) 2025-02-26
MX2021006864A (es) 2021-07-02
IL319975A (en) 2025-05-01
HUE068993T2 (hu) 2025-02-28
US11708403B2 (en) 2023-07-25
KR20210100688A (ko) 2021-08-17
US20200239554A1 (en) 2020-07-30
US11161900B2 (en) 2021-11-02

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