KR102742181B1 - 6-아자인돌 화합물 - Google Patents

6-아자인돌 화합물 Download PDF

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KR102742181B1
KR102742181B1 KR1020207020877A KR20207020877A KR102742181B1 KR 102742181 B1 KR102742181 B1 KR 102742181B1 KR 1020207020877 A KR1020207020877 A KR 1020207020877A KR 20207020877 A KR20207020877 A KR 20207020877A KR 102742181 B1 KR102742181 B1 KR 102742181B1
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pyridin
isopropyl
pyrrolo
triazolo
fluoro
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KR20200101956A (ko
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알라릭 제이. 딕맨
담펄 에스. 도드
스리칸타 라트나 쿠마르
두르가 부치 라주 바레
스리니바산 쿤치타파탐 두라이사미
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020207020877A 2017-12-19 2018-12-18 6-아자인돌 화합물 Active KR102742181B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762607507P 2017-12-19 2017-12-19
US62/607,507 2017-12-19
PCT/US2018/066107 WO2019126082A1 (en) 2017-12-19 2018-12-18 6-azaindole compounds

Publications (2)

Publication Number Publication Date
KR20200101956A KR20200101956A (ko) 2020-08-28
KR102742181B1 true KR102742181B1 (ko) 2024-12-11

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KR1020207020877A Active KR102742181B1 (ko) 2017-12-19 2018-12-18 6-아자인돌 화합물

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US (2) US11427580B2 (https=)
EP (1) EP3728253B1 (https=)
JP (1) JP7304352B2 (https=)
KR (1) KR102742181B1 (https=)
CN (1) CN111699185B (https=)
AU (1) AU2018390543A1 (https=)
BR (1) BR112020011788A2 (https=)
CA (1) CA3085761A1 (https=)
EA (1) EA202091508A1 (https=)
ES (1) ES2977657T3 (https=)
IL (1) IL275365A (https=)
MX (1) MX2020005873A (https=)
SG (1) SG11202005704RA (https=)
WO (1) WO2019126082A1 (https=)

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KR20210018818A (ko) 2018-06-05 2021-02-18 에프. 호프만-라 로슈 아게 자가면역 질환의 치료를 위한 테트라하이드로-1H-피라지노[2,1-a]이소인돌릴퀴놀린 화합물
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JP7367004B2 (ja) 2018-09-06 2023-10-23 エフ． ホフマン－ラ ロシュ アーゲー 自己免疫疾患の処置のための新規のピラゾロビリジン化合物
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JP7649306B2 (ja) 2019-11-20 2025-03-19 エフ． ホフマン－ラ ロシュ アーゲー 自己免疫疾患の処置のためのスピロ（イソベンゾフラナゼチジン）化合物
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CN116783202A (zh) * 2021-02-09 2023-09-19 吉利德科学公司 噻吩并吡咯化合物
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Also Published As

Publication number Publication date
CN111699185A (zh) 2020-09-22
IL275365A (en) 2020-07-30
US20220348576A1 (en) 2022-11-03
BR112020011788A2 (pt) 2020-11-24
AU2018390543A1 (en) 2020-08-06
WO2019126082A1 (en) 2019-06-27
CN111699185B (zh) 2023-06-27
KR20200101956A (ko) 2020-08-28
US20200385382A1 (en) 2020-12-10
EP3728253B1 (en) 2024-03-27
US11912703B2 (en) 2024-02-27
JP7304352B2 (ja) 2023-07-06
EP3728253A1 (en) 2020-10-28
EA202091508A1 (ru) 2020-09-14
CA3085761A1 (en) 2019-06-27
SG11202005704RA (en) 2020-07-29
MX2020005873A (es) 2020-08-13
US11427580B2 (en) 2022-08-30
JP2021507912A (ja) 2021-02-25
ES2977657T3 (es) 2024-08-28

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