KR102731644B1 - 키메라 수용체 및 그의 사용 방법 - Google Patents

키메라 수용체 및 그의 사용 방법 Download PDF

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KR102731644B1
KR102731644B1 KR1020237040899A KR20237040899A KR102731644B1 KR 102731644 B1 KR102731644 B1 KR 102731644B1 KR 1020237040899 A KR1020237040899 A KR 1020237040899A KR 20237040899 A KR20237040899 A KR 20237040899A KR 102731644 B1 KR102731644 B1 KR 102731644B1
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KR20230165383A (ko
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제드 윌치우스
루벤 알바레즈 로드리게즈
앨리스 배커
타라 아베드슨
로렌 우
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카이트 파마 인코포레이티드
암젠 인크
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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KR1020237040899A 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법 Active KR102731644B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247037911A KR102779944B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662317068P 2016-04-01 2016-04-01
US62/317,068 2016-04-01
PCT/US2017/025573 WO2017173384A1 (en) 2016-04-01 2017-03-31 Chimeric receptors and methods of use thereof
KR1020227039755A KR102608405B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법

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KR20230165383A KR20230165383A (ko) 2023-12-05
KR102731644B1 true KR102731644B1 (ko) 2024-11-19

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KR1020207015941A Ceased KR20200068750A (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020187031572A Active KR102120815B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020257007542A Pending KR20250039495A (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020247037911A Active KR102779944B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020227039755A Active KR102608405B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020237040899A Active KR102731644B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020217021089A Ceased KR20210089262A (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법

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KR1020207015941A Ceased KR20200068750A (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020187031572A Active KR102120815B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020257007542A Pending KR20250039495A (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020247037911A Active KR102779944B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법
KR1020227039755A Active KR102608405B1 (ko) 2016-04-01 2017-03-31 키메라 수용체 및 그의 사용 방법

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CN105939767B (zh) 2014-01-08 2018-04-06 弗洛设计声能学公司 具有双声电泳腔的声电泳装置
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
HUE054936T2 (hu) 2016-03-31 2021-10-28 Janssen Pharmaceuticals Inc Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai
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