KR102714554B1 - 신규한 치환된 크산틴 유도체 - Google Patents

신규한 치환된 크산틴 유도체 Download PDF

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KR102714554B1
KR102714554B1 KR1020207000260A KR20207000260A KR102714554B1 KR 102714554 B1 KR102714554 B1 KR 102714554B1 KR 1020207000260 A KR1020207000260 A KR 1020207000260A KR 20207000260 A KR20207000260 A KR 20207000260A KR 102714554 B1 KR102714554 B1 KR 102714554B1
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trpc5
compound
mmol
disorder
esi
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Korean (ko)
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KR20200030048A (ko
Inventor
카이 겔라크
크리스티안 아이크마이어
아킴 자우어
슈테판 유스트
버트랜드 엘. 체널드
Original Assignee
베링거 인겔하임 인터내셔날 게엠베하
하이드라 바이오사이언시스, 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020207000260A 2017-07-11 2018-07-06 신규한 치환된 크산틴 유도체 Active KR102714554B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17180721 2017-07-11
EP17180721.7 2017-07-11
PCT/EP2018/068366 WO2019011802A1 (en) 2017-07-11 2018-07-06 NEW SUBSTITUTED XANTHINE DERIVATIVES

Publications (2)

Publication Number Publication Date
KR20200030048A KR20200030048A (ko) 2020-03-19
KR102714554B1 true KR102714554B1 (ko) 2024-10-10

Family

ID=59325162

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207000260A Active KR102714554B1 (ko) 2017-07-11 2018-07-06 신규한 치환된 크산틴 유도체

Country Status (32)

Country Link
US (1) US10329292B2 (https=)
EP (1) EP3652176B1 (https=)
JP (1) JP7114702B2 (https=)
KR (1) KR102714554B1 (https=)
CN (1) CN110997675B (https=)
AR (1) AR112448A1 (https=)
AU (1) AU2018299824B2 (https=)
CA (1) CA3066922A1 (https=)
CL (1) CL2020000056A1 (https=)
CO (1) CO2019015102A2 (https=)
CY (1) CY1125014T1 (https=)
DK (1) DK3652176T3 (https=)
EA (1) EA039526B1 (https=)
ES (1) ES2903268T3 (https=)
HR (1) HRP20220029T1 (https=)
HU (1) HUE057600T2 (https=)
IL (1) IL271799B (https=)
LT (1) LT3652176T (https=)
MX (1) MX394089B (https=)
MY (1) MY200797A (https=)
PE (1) PE20200861A1 (https=)
PH (1) PH12020500079A1 (https=)
PL (1) PL3652176T3 (https=)
PT (1) PT3652176T (https=)
RS (1) RS62826B1 (https=)
SA (1) SA519410851B1 (https=)
SG (1) SG11201912168TA (https=)
SI (1) SI3652176T1 (https=)
SM (1) SMT202200013T1 (https=)
TW (1) TWI801398B (https=)
UA (1) UA124793C2 (https=)
WO (1) WO2019011802A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11623930B2 (en) 2018-03-05 2023-04-11 Goldfinch Bio, Inc. Imidazodiazepinediones and methods of use thereof
JP7502299B2 (ja) * 2018-12-12 2024-06-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換キサンチン誘導体
EP3894409B1 (en) * 2018-12-12 2023-08-23 Boehringer Ingelheim International GmbH Substituted xanthine derivatives
JP2022551580A (ja) * 2019-10-04 2022-12-12 ゴールドフィンチ バイオ，インク． 巣状分節性糸球体硬化症および糖尿病性腎症のバイオマーカーに基づく処置
CN118373832B (zh) * 2023-01-20 2025-01-28 深圳晶蛋生物医药科技有限公司 大环类化合物、其药物组合物及其应用
KR20250141831A (ko) 2023-02-08 2025-09-29 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 잔틴계 화합물 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100926247B1 (ko) * 2001-02-24 2009-11-12 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 크산틴 유도체를 포함하는 약제학적 조성물 및 이의제조방법
US6869947B2 (en) * 2001-07-03 2005-03-22 Novo Nordisk A/S Heterocyclic compounds that are inhibitors of the enzyme DPP-IV
AU2007274710A1 (en) * 2006-07-14 2008-01-24 Pfizer Products Inc. Tartrate salt of (7S)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2R)-2-methylpiperazin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridine
CA2899646C (en) * 2013-03-15 2021-08-31 Hydra Biosciences, Inc. Substituted xanthines and methods of use thereof
TWI676626B (zh) * 2014-04-23 2019-11-11 美商美國禮來大藥廠 抑制瞬時受體電位ａ１離子通道
JP6667093B2 (ja) 2014-08-11 2020-03-18 ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ， ＬＬＣ ピリド［２，３−ｄ］ピリミジン−２，４（１Ｈ，３Ｈ）−ジオン誘導体
WO2016023831A1 (en) 2014-08-11 2016-02-18 Hydra Biosciences, Inc. Pyrrolo[3,2-d]pyrimidine-2,4(3h,5h)-dione derivatives
EP3194367B1 (en) 2014-09-17 2021-08-18 Boehringer Ingelheim International GmbH Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes

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Publication number Publication date
HUE057600T2 (hu) 2022-05-28
PL3652176T3 (pl) 2022-04-04
JP2020526591A (ja) 2020-08-31
DK3652176T3 (da) 2022-01-17
PT3652176T (pt) 2022-01-13
MX394089B (es) 2025-03-24
EA039526B1 (ru) 2022-02-07
CL2020000056A1 (es) 2020-06-12
TWI801398B (zh) 2023-05-11
SG11201912168TA (en) 2020-01-30
EP3652176A1 (en) 2020-05-20
LT3652176T (lt) 2022-02-25
EA202090270A1 (ru) 2020-04-24
ES2903268T3 (es) 2022-03-31
PH12020500079A1 (en) 2020-10-05
NZ759728A (en) 2024-11-29
IL271799B (en) 2022-08-01
SMT202200013T1 (it) 2022-03-21
CN110997675A (zh) 2020-04-10
US10329292B2 (en) 2019-06-25
WO2019011802A1 (en) 2019-01-17
JP7114702B2 (ja) 2022-08-08
CO2019015102A2 (es) 2020-05-15
MX2020000402A (es) 2020-08-17
EP3652176B1 (en) 2021-12-15
US20190016722A1 (en) 2019-01-17
SA519410851B1 (ar) 2023-02-26
BR112019025611A2 (pt) 2020-06-16
CN110997675B (zh) 2022-06-07
CA3066922A1 (en) 2019-01-17
HRP20220029T1 (hr) 2022-04-15
SI3652176T1 (sl) 2022-04-29
IL271799A (en) 2020-02-27
CY1125014T1 (el) 2023-03-24
KR20200030048A (ko) 2020-03-19
RS62826B1 (sr) 2022-02-28
AR112448A1 (es) 2019-10-30
TW201908318A (zh) 2019-03-01
AU2018299824B2 (en) 2022-06-16
PE20200861A1 (es) 2020-08-25
AU2018299824A1 (en) 2019-12-19
MY200797A (en) 2024-01-16
UA124793C2 (uk) 2021-11-17

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