KR102696517B1 - 치환된 뉴클레오시드, 뉴클레오티드 및 이들의 유사체 - Google Patents

치환된 뉴클레오시드, 뉴클레오티드 및 이들의 유사체 Download PDF

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KR102696517B1
KR102696517B1 KR1020207011130A KR20207011130A KR102696517B1 KR 102696517 B1 KR102696517 B1 KR 102696517B1 KR 1020207011130 A KR1020207011130 A KR 1020207011130A KR 20207011130 A KR20207011130 A KR 20207011130A KR 102696517 B1 KR102696517 B1 KR 102696517B1
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compound
pharmaceutically acceptable
acceptable salt
formula
alkyl
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KR20200098483A (ko
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레오니드 베이겔만
제롬 드발
마리자 프라브크
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얀센 바이오파마, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020207011130A 2017-09-18 2018-09-18 치환된 뉴클레오시드, 뉴클레오티드 및 이들의 유사체 Active KR102696517B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762560110P 2017-09-18 2017-09-18
US62/560,110 2017-09-18
PCT/IB2018/057188 WO2019053696A1 (en) 2017-09-18 2018-09-18 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

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KR20200098483A KR20200098483A (ko) 2020-08-20
KR102696517B1 true KR102696517B1 (ko) 2024-08-21

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US (2) US11149049B2 (enExample)
EP (1) EP3684782A1 (enExample)
JP (1) JP2020534361A (enExample)
KR (1) KR102696517B1 (enExample)
CN (1) CN111542531B (enExample)
AU (1) AU2018332540B2 (enExample)
CA (1) CA3075950A1 (enExample)
CL (1) CL2020000685A1 (enExample)
CR (1) CR20200126A (enExample)
EA (1) EA202090775A1 (enExample)
EC (1) ECSP20022130A (enExample)
IL (1) IL273341A (enExample)
MA (1) MA50172A (enExample)
MX (1) MX2020002925A (enExample)
PH (1) PH12020550114A1 (enExample)
SG (1) SG11202002295QA (enExample)
WO (1) WO2019053696A1 (enExample)

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MX2020002925A (es) 2020-10-05
US20200277321A1 (en) 2020-09-03
CA3075950A1 (en) 2019-03-21
KR20200098483A (ko) 2020-08-20
ECSP20022130A (es) 2020-07-31
MA50172A (fr) 2021-04-07
AU2018332540B2 (en) 2023-10-05
BR112020005177A2 (pt) 2020-09-15
EA202090775A1 (ru) 2020-07-06
CR20200126A (es) 2020-07-11
US20210395288A1 (en) 2021-12-23
PH12020550114A1 (en) 2020-12-07
CN111542531A (zh) 2020-08-14
IL273341A (en) 2020-05-31
WO2019053696A1 (en) 2019-03-21
EP3684782A1 (en) 2020-07-29
AU2018332540A1 (en) 2020-04-30
US11149049B2 (en) 2021-10-19
CL2020000685A1 (es) 2020-10-23
SG11202002295QA (en) 2020-04-29
CN111542531B (zh) 2024-07-19
JP2020534361A (ja) 2020-11-26
US11773126B2 (en) 2023-10-03

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