KR102674630B1 - 항암제로서의 시클릭 디뉴클레오티드 - Google Patents
항암제로서의 시클릭 디뉴클레오티드 Download PDFInfo
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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Landscapes
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- Peptides Or Proteins (AREA)
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| PCT/US2018/048666 WO2019046500A1 (en) | 2017-08-31 | 2018-08-30 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS |
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| PE20210156A1 (es) | 2017-11-10 | 2021-01-26 | Takeda Pharmaceuticals Co | Compuestos moduladores de sting y metodos de elaboracion y uso |
| WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
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| US11685761B2 (en) * | 2017-12-20 | 2023-06-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| US10519187B2 (en) | 2018-02-13 | 2019-12-31 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| ES2980374T3 (es) * | 2018-03-08 | 2024-10-01 | Bristol Myers Squibb Co | Dinucleótidos cíclicos como agentes anticancerosos |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
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| KR20210015937A (ko) | 2018-06-01 | 2021-02-10 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 방광암을 치료하기 위한 방법 |
| US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
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| TW202114710A (zh) | 2019-07-25 | 2021-04-16 | 英屬開曼群島商百濟神州有限公司 | 作為sting促效劑之環狀二核苷酸 |
| EP4134098A4 (en) | 2020-04-10 | 2024-05-15 | ONO Pharmaceutical Co., Ltd. | Method of cancer therapy |
| EP4240488A1 (en) | 2020-11-09 | 2023-09-13 | Takeda Pharmaceutical Company Limited | Antibody drug conjugates |
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| WO2016120305A1 (en) | 2015-01-29 | 2016-08-04 | Glaxosmithkline Intellectual Property Development Limited | Cyclic dinucleotides useful for the treatment of inter alia cancer |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
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- 2018-08-30 US US16/642,424 patent/US10953032B2/en active Active
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| US10953032B2 (en) | 2021-03-23 |
| KR20200042938A (ko) | 2020-04-24 |
| EP3676279A1 (en) | 2020-07-08 |
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| ES2904317T3 (es) | 2022-04-04 |
| EP3676279B1 (en) | 2021-12-01 |
| CN111051328A (zh) | 2020-04-21 |
| US20200253997A1 (en) | 2020-08-13 |
| WO2019046500A1 (en) | 2019-03-07 |
| CN111051328B (zh) | 2023-11-03 |
| JP7208225B2 (ja) | 2023-01-18 |
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