ES2904317T3 - Dinucleótidos cíclicos como agentes anticancerosos - Google Patents
Dinucleótidos cíclicos como agentes anticancerosos Download PDFInfo
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- ES2904317T3 ES2904317T3 ES18766543T ES18766543T ES2904317T3 ES 2904317 T3 ES2904317 T3 ES 2904317T3 ES 18766543 T ES18766543 T ES 18766543T ES 18766543 T ES18766543 T ES 18766543T ES 2904317 T3 ES2904317 T3 ES 2904317T3
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- nra1ra1
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- acceptable salt
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- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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| EP3727401A4 (en) * | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS |
| US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| US10519187B2 (en) * | 2018-02-13 | 2019-12-31 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| US11945834B2 (en) * | 2018-03-08 | 2024-04-02 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
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2018
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- 2018-08-30 CN CN201880055913.XA patent/CN111051328B/zh active Active
- 2018-08-30 EP EP18766543.5A patent/EP3676279B1/en active Active
- 2018-08-30 KR KR1020207008751A patent/KR102674630B1/ko active Active
- 2018-08-30 US US16/642,424 patent/US10953032B2/en active Active
- 2018-08-30 JP JP2020512379A patent/JP7208225B2/ja active Active
- 2018-08-30 WO PCT/US2018/048666 patent/WO2019046500A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20200253997A1 (en) | 2020-08-13 |
| WO2019046500A1 (en) | 2019-03-07 |
| EP3676279B1 (en) | 2021-12-01 |
| JP7208225B2 (ja) | 2023-01-18 |
| EP3676279A1 (en) | 2020-07-08 |
| KR102674630B1 (ko) | 2024-06-11 |
| JP2020532529A (ja) | 2020-11-12 |
| KR20200042938A (ko) | 2020-04-24 |
| CN111051328A (zh) | 2020-04-21 |
| CN111051328B (zh) | 2023-11-03 |
| US10953032B2 (en) | 2021-03-23 |
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