KR102673794B1 - 나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도 - Google Patents

나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도 Download PDF

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KR102673794B1
KR102673794B1 KR1020207001253A KR20207001253A KR102673794B1 KR 102673794 B1 KR102673794 B1 KR 102673794B1 KR 1020207001253 A KR1020207001253 A KR 1020207001253A KR 20207001253 A KR20207001253 A KR 20207001253A KR 102673794 B1 KR102673794 B1 KR 102673794B1
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lipid
rna
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KR20200028395A (ko
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크리스토퍼 비. 폭스
아미트 프라풀 칸다르
호에벤 닐 반
제시 에이치. 에라스무스
수잔 에스. 린
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액세스 투 어드밴스드 헬스 인스티튜트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/53—DNA (RNA) vaccination
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    • A61K2039/55505—Inorganic adjuvants
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    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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    • C12N2770/24011—Flaviviridae
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    • C12N2770/00011—Details
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    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020207001253A 2017-06-15 2018-06-15 나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도 Active KR102673794B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247018651A KR20240096685A (ko) 2017-06-15 2018-06-15 나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201762520204P 2017-06-15 2017-06-15
US62/520,204 2017-06-15
US201762540973P 2017-08-03 2017-08-03
US62/540,973 2017-08-03
US201762556291P 2017-09-08 2017-09-08
US62/556,291 2017-09-08
US201762563544P 2017-09-26 2017-09-26
US62/563,544 2017-09-26
US201762582859P 2017-11-07 2017-11-07
US62/582,859 2017-11-07
US201862622748P 2018-01-26 2018-01-26
US201862622755P 2018-01-26 2018-01-26
US62/622,748 2018-01-26
US62/622,755 2018-01-26
US201862669262P 2018-05-09 2018-05-09
US62/669,262 2018-05-09
US201862677336P 2018-05-29 2018-05-29
US62/677,336 2018-05-29
US201862680454P 2018-06-04 2018-06-04
US62/680,454 2018-06-04
PCT/US2018/037783 WO2018232257A1 (en) 2017-06-15 2018-06-15 Nanostructured lipid carriers and stable emulsions and uses thereof

Related Child Applications (1)

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KR1020247018651A Division KR20240096685A (ko) 2017-06-15 2018-06-15 나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도

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KR20200028395A KR20200028395A (ko) 2020-03-16
KR102673794B1 true KR102673794B1 (ko) 2024-06-11

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KR1020207001253A Active KR102673794B1 (ko) 2017-06-15 2018-06-15 나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도

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US (3) US11141377B2 (enExample)
EP (1) EP3638207B1 (enExample)
JP (2) JP2020524143A (enExample)
KR (2) KR20240096685A (enExample)
CN (1) CN111315362A (enExample)
AU (1) AU2018285694B2 (enExample)
BR (1) BR112019026615B1 (enExample)
CA (1) CA3067224A1 (enExample)
ES (1) ES3003260T3 (enExample)
IL (1) IL271384B2 (enExample)
MX (4) MX2019015076A (enExample)
WO (1) WO2018232257A1 (enExample)
ZA (1) ZA201908207B (enExample)

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US11679163B2 (en) 2019-09-20 2023-06-20 Hdt Bio Corp. Compositions and methods for delivery of RNA
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CN115955959A (zh) * 2020-02-26 2023-04-11 康普萨姆公司 纳米结构脂质载体递送系统、组合物和方法
JP2023518976A (ja) 2020-03-23 2023-05-09 エイチディーティー バイオ コーポレーション Ｒｎａを送達するための組成物および方法
CN111494619B (zh) * 2020-04-26 2022-03-18 南京农业大学 一种基于角鲨烯的阳离子纳米结构脂质载体免疫佐剂的制备方法
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CA3174411A1 (en) * 2020-09-04 2022-03-10 Ryan M. Kramer Co-lyophilized rna and nanostructured lipid carrier
AU2021406131A1 (en) * 2020-12-23 2023-08-03 Access To Advanced Health Institute Solanesol vaccine adjuvants and methods of preparing same
US20240252620A1 (en) * 2021-05-28 2024-08-01 The Regents Of The University Of Michigan Combined agonist adjuvant for coronavirus vaccine
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