KR102620487B1 - 백신으로 사용하기 위한 엑소좀-앵커링 단백질을 발현하는 뉴클레오티드 서열 - Google Patents

백신으로 사용하기 위한 엑소좀-앵커링 단백질을 발현하는 뉴클레오티드 서열 Download PDF

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KR102620487B1
KR102620487B1 KR1020197013580A KR20197013580A KR102620487B1 KR 102620487 B1 KR102620487 B1 KR 102620487B1 KR 1020197013580 A KR1020197013580 A KR 1020197013580A KR 20197013580 A KR20197013580 A KR 20197013580A KR 102620487 B1 KR102620487 B1 KR 102620487B1
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마우리지오 파올로 마리아 페데리코
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이스티튜토 수퍼리오레 디 사니타
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KR1020197013580A 2016-10-11 2017-10-11 백신으로 사용하기 위한 엑소좀-앵커링 단백질을 발현하는 뉴클레오티드 서열 Active KR102620487B1 (ko)

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Application Number Priority Date Filing Date Title
IT102016000101794A IT201600101794A1 (it) 2016-10-11 2016-10-11 Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.
IT102016000101794 2016-10-11
PCT/IT2017/000223 WO2018069947A1 (en) 2016-10-11 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine

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KR102620487B1 true KR102620487B1 (ko) 2024-01-03

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Publication number Priority date Publication date Assignee Title
IT201600101794A1 (it) 2016-10-11 2018-04-11 St Superiore Di Sanita Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.
IT202000009688A1 (it) 2020-05-04 2021-11-04 Biovelocita S R L Proteine di fusione di ancoraggio a esosomi
WO2021224429A1 (en) 2020-05-06 2021-11-11 Biovelocita S.R.L Exosome-anchoring coronavirus fusion proteins and vaccines
IT202000030740A1 (it) * 2020-12-14 2022-06-14 St Superiore Di Sanita SEQUENZA NUCLEOTIDICA ESPRIMENTE UNA PROTEINA ANCORANTE VESCICOLE EXTRACELLULARI FUSA AD ANTIGENI DI SARS-CoV-2 E RELATIVA PROTEINA DI FUSIONE PER L’USO COME VACCINO

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534285B1 (en) * 1984-12-24 2003-03-18 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
GB0118532D0 (en) * 2001-07-30 2001-09-19 Isis Innovation Materials and methods relating to improved vaccination strategies
FR2928926B1 (fr) 2008-03-18 2015-08-21 Centre Nat Rech Scient Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes
WO2011119628A2 (en) * 2010-03-23 2011-09-29 The Regents Of The University Of California Compositions and methods for self-adjuvanting vaccines against microbes and tumors
US20130101614A1 (en) 2010-06-15 2013-04-25 The Regents Of The University Of California Novel live recombinant booster vaccine against tuberculosis
US10004793B2 (en) 2014-04-24 2018-06-26 Statens Serum Institut M.tuberculosis vaccines
IT201600101794A1 (it) 2016-10-11 2018-04-11 St Superiore Di Sanita Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.
IT201600131935A1 (it) 2016-12-29 2018-06-29 Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA.
US11130787B2 (en) 2020-06-11 2021-09-28 MBF Therapeutics, Inc. Alphaherpesvirus glycoprotein d-encoding nucleic acid constructs and methods
CN112409496B (zh) 2020-11-26 2021-07-13 焦顺昌 一种跨膜表达新型冠状病毒抗原s2的融合蛋白、重组载体、重组树突状细胞及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cancer Res., Vol.68, No.4, pp.1228-1235(2008.02.15.)*
Viruses, Vol.7, No.3, pp.1079-1099(2015.03.09.)*

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WO2018069947A8 (en) 2019-07-04
HUE050492T2 (hu) 2020-12-28
CA3040035A1 (en) 2018-04-19
AU2017343893B2 (en) 2024-06-13
IL265942B2 (en) 2023-11-01
JP2022071130A (ja) 2022-05-13
US20230364211A1 (en) 2023-11-16
SG11201903235XA (en) 2019-05-30
JP2019536473A (ja) 2019-12-19
KR20190079628A (ko) 2019-07-05
EP3389701B1 (en) 2020-04-29
WO2018069947A1 (en) 2018-04-19
NZ753370A (en) 2024-01-26
US11559571B2 (en) 2023-01-24
JP7340639B2 (ja) 2023-09-07
CN110049775A (zh) 2019-07-23
AU2017343893A1 (en) 2019-05-30
RU2761642C2 (ru) 2021-12-13
CN117210480A (zh) 2023-12-12
IL265942B1 (en) 2023-07-01
EP3389701A1 (en) 2018-10-24
MX2019004183A (es) 2020-09-03
IT201600101794A1 (it) 2018-04-11
IL265942A (en) 2019-05-30
RU2019114370A (ru) 2020-11-13
BR112019007343A2 (pt) 2019-10-01
US20200206329A1 (en) 2020-07-02
RU2019114370A3 (enExample) 2021-03-01
ES2809212T3 (es) 2021-03-03
DK3389701T3 (da) 2020-08-03

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