IT201600131935A1 - Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA. - Google Patents

Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA.

Info

Publication number
IT201600131935A1
IT201600131935A1 IT102016000131935A IT201600131935A IT201600131935A1 IT 201600131935 A1 IT201600131935 A1 IT 201600131935A1 IT 102016000131935 A IT102016000131935 A IT 102016000131935A IT 201600131935 A IT201600131935 A IT 201600131935A IT 201600131935 A1 IT201600131935 A1 IT 201600131935A1
Authority
IT
Italy
Prior art keywords
adjunct
signal sequence
plant protein
dna vaccines
vaccines
Prior art date
Application number
IT102016000131935A
Other languages
English (en)
Inventor
Rosella Franconi
Silvia Massa
Aldo Venuti
Original Assignee
Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile
St Fisioterapici Ospitalieri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile, St Fisioterapici Ospitalieri filed Critical Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile
Priority to IT102016000131935A priority Critical patent/IT201600131935A1/it
Priority to EP17826321.6A priority patent/EP3562504B1/en
Priority to PCT/IT2017/050008 priority patent/WO2018122885A1/en
Publication of IT201600131935A1 publication Critical patent/IT201600131935A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/40011—Tymoviridae
    • C12N2770/40034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
IT102016000131935A 2016-12-29 2016-12-29 Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA. IT201600131935A1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT102016000131935A IT201600131935A1 (it) 2016-12-29 2016-12-29 Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA.
EP17826321.6A EP3562504B1 (en) 2016-12-29 2017-12-22 Dna vaccine comprising a polynucleotide sequence encoding a fusion protein encompassing a plant protein signal sequence
PCT/IT2017/050008 WO2018122885A1 (en) 2016-12-29 2017-12-22 Plant protein signal sequence as adjuvant in dna vaccines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102016000131935A IT201600131935A1 (it) 2016-12-29 2016-12-29 Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA.

Publications (1)

Publication Number Publication Date
IT201600131935A1 true IT201600131935A1 (it) 2018-06-29

Family

ID=58609915

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102016000131935A IT201600131935A1 (it) 2016-12-29 2016-12-29 Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA.

Country Status (3)

Country Link
EP (1) EP3562504B1 (it)
IT (1) IT201600131935A1 (it)
WO (1) WO2018122885A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600101794A1 (it) 2016-10-11 2018-04-11 St Superiore Di Sanita Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.
IT202000009688A1 (it) * 2020-05-04 2021-11-04 Biovelocita S R L Proteine di fusione di ancoraggio a esosomi

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011010337A1 (en) * 2009-07-21 2011-01-27 Enea - Ente Per Le Nuove Technologie, L'energia E L'ambiente Vaccines based on genetic chimera of viral and/or tumoral antigens and vegetable proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011010337A1 (en) * 2009-07-21 2011-01-27 Enea - Ente Per Le Nuove Technologie, L'energia E L'ambiente Vaccines based on genetic chimera of viral and/or tumoral antigens and vegetable proteins

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
EMANUELA NORIS ET AL: "A human papillomavirus 8 E7 protein produced in plants is able to trigger the mouse immune system and delay the development of skin lesions", ARCHIVES OF VIROLOGY ; OFFICIAL JOURNAL OF THE VIROLOGY DIVISIONOF THE INTERNATIONAL UNION OF MICROBIOLOGICAL SOCIETIES, SPRINGER-VERLAG, VI, vol. 156, no. 4, 15 January 2011 (2011-01-15), pages 587 - 595, XP019891267, ISSN: 1432-8798, DOI: 10.1007/S00705-010-0893-8 *
FRANCONI R ET AL: "Exploiting the plant secretory pathway to improve the anticancer activity of a plant-derived HPV16 E7 vaccine", INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, SAGE PUBLICATIONS LTD, GB, vol. 19, no. 1, 1 January 2006 (2006-01-01), pages 187 - 197, XP009160218, ISSN: 0394-6320 *
GIORGI C ET AL: "Human papillomavirus vaccines in plants", EXPERT REVIEW OF VACC, FUTURE DRUGS, LONDON, GB, vol. 9, no. 9, 1 January 2010 (2010-01-01), pages 913 - 924, XP009181587, ISSN: 1476-0584, DOI: 10.1586/ERV.10.84 *
MASSA SILVIA ET AL: "Antitumor activity of DNA vaccines based on the human papillomavirus-16 E7 protein genetically fused to a plant virus coat protein", HUMAN GENE THE, MARY ANN LIEBERT, INC. PUBLISHERS, US, vol. 19, no. 4, 1 April 2008 (2008-04-01), pages 354 - 364, XP009129816, ISSN: 1043-0342, DOI: 10.1089/HUM.2007.122 *
VACULIK PETR ET AL: "Potato virus Xdisplaying the E7 peptide derived fromhuman papillomavirustype 16: a novel position for epitope presentation", PLANT CELL, TISSUE AND ORGAN CULTURE, SPRINGER, NL, vol. 120, no. 2, 2 October 2014 (2014-10-02), pages 671 - 680, XP035435921, ISSN: 0167-6857, [retrieved on 20141002], DOI: 10.1007/S11240-014-0634-X *
YOSHIKATSU MATSUBAYASHI: "Posttranslationally Modified Small-Peptide Signals in Plants", ANNUAL REVIEW OF PLANT BIOLOGY, vol. 65, no. 1, 29 April 2014 (2014-04-29), US, pages 385 - 413, XP055405271, ISSN: 1543-5008, DOI: 10.1146/annurev-arplant-050312-120122 *

Also Published As

Publication number Publication date
EP3562504A1 (en) 2019-11-06
WO2018122885A1 (en) 2018-07-05
EP3562504B1 (en) 2023-04-19

Similar Documents

Publication Publication Date Title
DK3433368T3 (da) Transreplikerende rna
DK3708668T3 (da) Kunstigt nukleinsyremolekyle til forbedret proteinudtrykkelse
DK3292141T3 (da) Fusionsproteiner
DK3197453T3 (da) Kimært protein
DK3292137T3 (da) Proteiner specifikke for cd137
DK3298718T3 (da) Teknikker til signal-forlængelsessignalering
MA53616A (fr) Protéines bispécifiques modifiées
ES2966831T3 (es) Técnicas de indexación de ácidos nucleicos
DK3143138T3 (da) Betinget aktive biologiske proteiner
CL2018000520A1 (es) Proteinas inhibidoras de insectos novedosas
DK3368655T3 (da) Forbedret proteinekspression og fremgangsmåder dertil
ITUA20162445A1 (it) Dispositivo di prelievo di articoli.
MA50908A (fr) Formulations de protéines de fusion vegfr-fc
DK3464331T3 (da) Stabiliserede præfusions-rsv f-proteiner
DK3730511T3 (da) Proteinoprensning
BR112017001684A2 (pt) preparação de produto de proteína de pulso ("yp810")
DK3262168T3 (da) Værtscelleproteinmodifikation
DK3099791T3 (da) Protein
ZA201902418B (en) Novel insect inhibitory proteins
DK3484921T3 (da) Anti-IL-22R antistoffer
IT201700066102A1 (it) Sistema di radiofaro
EP3557996C0 (en) NEW INSECTICIDAL PROTEINS
IT201600131935A1 (it) Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA.
DK3271724T3 (da) Anvendelse af en standard til påvisning af proteinaggregater i en proteinfejlfoldningssygdom
ITUA20161638A1 (it) Sistema migliorato di impianto dentale