IT201600101794A1 - Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino. - Google Patents

Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.

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Publication number
IT201600101794A1
IT201600101794A1 IT102016000101794A IT201600101794A IT201600101794A1 IT 201600101794 A1 IT201600101794 A1 IT 201600101794A1 IT 102016000101794 A IT102016000101794 A IT 102016000101794A IT 201600101794 A IT201600101794 A IT 201600101794A IT 201600101794 A1 IT201600101794 A1 IT 201600101794A1
Authority
IT
Italy
Prior art keywords
exosome
vaccine
nucleotide sequence
anchoring protein
sequence expressing
Prior art date
Application number
IT102016000101794A
Other languages
English (en)
Inventor
Maurizio Paolo Maria Federico
Original Assignee
St Superiore Di Sanita
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Superiore Di Sanita filed Critical St Superiore Di Sanita
Priority to IT102016000101794A priority Critical patent/IT201600101794A1/it
Priority to US16/341,042 priority patent/US11559571B2/en
Priority to KR1020197013580A priority patent/KR102620487B1/ko
Priority to SG11201903235XA priority patent/SG11201903235XA/en
Priority to NZ753370A priority patent/NZ753370B2/en
Priority to IL265942A priority patent/IL265942B2/en
Priority to JP2019540142A priority patent/JP2019536473A/ja
Priority to DK17826320.8T priority patent/DK3389701T3/da
Priority to AU2017343893A priority patent/AU2017343893B2/en
Priority to RU2019114370A priority patent/RU2761642C2/ru
Priority to BR112019007343A priority patent/BR112019007343A2/pt
Priority to EP17826320.8A priority patent/EP3389701B1/en
Priority to MX2019004183A priority patent/MX2019004183A/es
Priority to CA3040035A priority patent/CA3040035A1/en
Priority to HUE17826320A priority patent/HUE050492T2/hu
Priority to CN202310836753.5A priority patent/CN117210480A/zh
Priority to ES17826320T priority patent/ES2809212T3/es
Priority to CN201780076288.2A priority patent/CN110049775A/zh
Priority to PCT/IT2017/000223 priority patent/WO2018069947A1/en
Publication of IT201600101794A1 publication Critical patent/IT201600101794A1/it
Priority to JP2022032547A priority patent/JP7340639B2/ja
Priority to US18/157,534 priority patent/US20230364211A1/en

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    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
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    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
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    • A61K39/4643—Vertebrate antigens
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    • A61K39/464486—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2740/00011—Details
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    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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IT102016000101794A 2016-10-11 2016-10-11 Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino. IT201600101794A1 (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IT102016000101794A IT201600101794A1 (it) 2016-10-11 2016-10-11 Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.
RU2019114370A RU2761642C2 (ru) 2016-10-11 2017-10-11 Нуклеотидная последовательность, экспрессирующая якорный белок экзосом для применения в качестве вакцины
MX2019004183A MX2019004183A (es) 2016-10-11 2017-10-11 Secuencia de nucleotidos que expresa una proteina de anclaje a exosoma para su uso como vacuna.
SG11201903235XA SG11201903235XA (en) 2016-10-11 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine
NZ753370A NZ753370B2 (en) 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine
IL265942A IL265942B2 (en) 2016-10-11 2017-10-11 A nucleotide sequence expressing an exosome anchor protein for use as a component
JP2019540142A JP2019536473A (ja) 2016-10-11 2017-10-11 ワクチンとして使用するためのエキソソームアンカータンパク質を発現するヌクレオチド配列
DK17826320.8T DK3389701T3 (da) 2016-10-11 2017-10-11 Nucleotidesekvens, der udtrykker et exosomforankrende, protein til anvendelse som vaccine
AU2017343893A AU2017343893B2 (en) 2016-10-11 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine
US16/341,042 US11559571B2 (en) 2016-10-11 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine
BR112019007343A BR112019007343A2 (pt) 2016-10-11 2017-10-11 sequência de nucleotídeos expressando uma proteína de ancoragem de exossomo para uso como vacina
EP17826320.8A EP3389701B1 (en) 2016-10-11 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine
KR1020197013580A KR102620487B1 (ko) 2016-10-11 2017-10-11 백신으로 사용하기 위한 엑소좀-앵커링 단백질을 발현하는 뉴클레오티드 서열
CA3040035A CA3040035A1 (en) 2016-10-11 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine
HUE17826320A HUE050492T2 (hu) 2016-10-11 2017-10-11 Exoszómát horgonyzó fehérjét expresszáló nukleotid-szekvencia vakcinaként történõ alkamazásra
CN202310836753.5A CN117210480A (zh) 2016-10-11 2017-10-11 用作疫苗的表达外泌体锚定蛋白的核苷酸序列
ES17826320T ES2809212T3 (es) 2016-10-11 2017-10-11 Secuencia de nucleótidos que expresa una proteína de anclaje al exosoma para usar como vacuna
CN201780076288.2A CN110049775A (zh) 2016-10-11 2017-10-11 用作疫苗的表达外泌体锚定蛋白的核苷酸序列
PCT/IT2017/000223 WO2018069947A1 (en) 2016-10-11 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine
JP2022032547A JP7340639B2 (ja) 2016-10-11 2022-03-03 ワクチンとして使用するためのエキソソームアンカータンパク質を発現するヌクレオチド配列
US18/157,534 US20230364211A1 (en) 2016-10-11 2023-01-20 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102016000101794A IT201600101794A1 (it) 2016-10-11 2016-10-11 Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.

Publications (1)

Publication Number Publication Date
IT201600101794A1 true IT201600101794A1 (it) 2018-04-11

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IT102016000101794A IT201600101794A1 (it) 2016-10-11 2016-10-11 Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.

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US (2) US11559571B2 (it)
EP (1) EP3389701B1 (it)
JP (2) JP2019536473A (it)
KR (1) KR102620487B1 (it)
CN (2) CN110049775A (it)
AU (1) AU2017343893B2 (it)
BR (1) BR112019007343A2 (it)
CA (1) CA3040035A1 (it)
DK (1) DK3389701T3 (it)
ES (1) ES2809212T3 (it)
HU (1) HUE050492T2 (it)
IL (1) IL265942B2 (it)
IT (1) IT201600101794A1 (it)
MX (1) MX2019004183A (it)
RU (1) RU2761642C2 (it)
SG (1) SG11201903235XA (it)
WO (1) WO2018069947A1 (it)

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IT202000009688A1 (it) 2020-05-04 2021-11-04 Biovelocita S R L Proteine di fusione di ancoraggio a esosomi
WO2021224429A1 (en) 2020-05-06 2021-11-11 Biovelocita S.R.L Exosome-anchoring coronavirus fusion proteins and vaccines
IT202000030740A1 (it) 2020-12-14 2022-06-14 St Superiore Di Sanita SEQUENZA NUCLEOTIDICA ESPRIMENTE UNA PROTEINA ANCORANTE VESCICOLE EXTRACELLULARI FUSA AD ANTIGENI DI SARS-CoV-2 E RELATIVA PROTEINA DI FUSIONE PER L’USO COME VACCINO

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SG11201903235XA (en) 2019-05-30
RU2019114370A3 (it) 2021-03-01
JP2019536473A (ja) 2019-12-19
EP3389701B1 (en) 2020-04-29
WO2018069947A8 (en) 2019-07-04
KR102620487B1 (ko) 2024-01-03
MX2019004183A (es) 2020-09-03
US20230364211A1 (en) 2023-11-16
CA3040035A1 (en) 2018-04-19
AU2017343893B2 (en) 2024-06-13
CN110049775A (zh) 2019-07-23
NZ753370A (en) 2024-01-26
RU2761642C2 (ru) 2021-12-13
AU2017343893A1 (en) 2019-05-30
BR112019007343A2 (pt) 2019-10-01
DK3389701T3 (da) 2020-08-03
RU2019114370A (ru) 2020-11-13
IL265942A (en) 2019-05-30
JP7340639B2 (ja) 2023-09-07
IL265942B1 (en) 2023-07-01
IL265942B2 (en) 2023-11-01
KR20190079628A (ko) 2019-07-05
HUE050492T2 (hu) 2020-12-28
WO2018069947A1 (en) 2018-04-19
US20200206329A1 (en) 2020-07-02
ES2809212T3 (es) 2021-03-03
US11559571B2 (en) 2023-01-24
EP3389701A1 (en) 2018-10-24
JP2022071130A (ja) 2022-05-13
CN117210480A (zh) 2023-12-12

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