KR102609333B1 - Ｎ-（2,6-디에틸페닐）-8-（｛4-〔4-（디메틸아미노）피페리딘-1-일〕-2-메톡시페닐｝아미노）-1-메틸-4,5-디하이드로-1ｈ-피라졸로〔4,3-ｈ〕퀴나졸린-3-카복사미드의 신규한 염, 이의 제조, 및 이를 함유하는 제형 - Google Patents

Ｎ-（2,6-디에틸페닐）-8-（｛4-〔4-（디메틸아미노）피페리딘-1-일〕-2-메톡시페닐｝아미노）-1-메틸-4,5-디하이드로-1ｈ-피라졸로〔4,3-ｈ〕퀴나졸린-3-카복사미드의 신규한 염, 이의 제조, 및 이를 함유하는 제형 Download PDF

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KR102609333B1
KR102609333B1 KR1020207002339A KR20207002339A KR102609333B1 KR 102609333 B1 KR102609333 B1 KR 102609333B1 KR 1020207002339 A KR1020207002339 A KR 1020207002339A KR 20207002339 A KR20207002339 A KR 20207002339A KR 102609333 B1 KR102609333 B1 KR 102609333B1
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cancer
methyl
amino
pyrazolo
quinazoline
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KR20200020905A (ko
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마시모 잠피에리
마리나 칼다렐리
일라리아 칸디아니
마떼오 디'안넬로
게르마노 디'아라스모
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네르비아노 메디칼 사이언시스 에스.알.엘.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020207002339A 2017-06-29 2018-06-28 Ｎ-（2,6-디에틸페닐）-8-（｛4-〔4-（디메틸아미노）피페리딘-1-일〕-2-메톡시페닐｝아미노）-1-메틸-4,5-디하이드로-1ｈ-피라졸로〔4,3-ｈ〕퀴나졸린-3-카복사미드의 신규한 염, 이의 제조, 및 이를 함유하는 제형 Active KR102609333B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305826 2017-06-29
EP17305826.4 2017-06-29
PCT/EP2018/067394 WO2019002454A1 (en) 2017-06-29 2018-06-28 NOVEL N- (2,6-DIETHYLPHENYL) -8 - ({4- [4- (DIMETHYLAMINO) PIPERIDIN-1-YL] -2-METHOXYPHENYL} AMINO) -1-METHYL-4,5-DIHYDRO-1H SALT -PYRAZOLO [4,3-H] QUINAZOLINE-3-CARBOXAMIDE, ITS PREPARATION AND FORMULATIONS CONTAINING THE SAME

Publications (2)

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KR20200020905A KR20200020905A (ko) 2020-02-26
KR102609333B1 true KR102609333B1 (ko) 2023-12-01

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KR1020207002339A Active KR102609333B1 (ko) 2017-06-29 2018-06-28 Ｎ-（2,6-디에틸페닐）-8-（｛4-〔4-（디메틸아미노）피페리딘-1-일〕-2-메톡시페닐｝아미노）-1-메틸-4,5-디하이드로-1ｈ-피라졸로〔4,3-ｈ〕퀴나졸린-3-카복사미드의 신규한 염, 이의 제조, 및 이를 함유하는 제형

Country Status (19)

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US (3) US11160806B2 (https=)
EP (1) EP3645535B1 (https=)
JP (1) JP7141416B2 (https=)
KR (1) KR102609333B1 (https=)
CN (1) CN110896636B (https=)
AR (1) AR112040A1 (https=)
AU (1) AU2018293729B9 (https=)
CA (1) CA3068357C (https=)
CL (1) CL2019003848A1 (https=)
EA (1) EA039764B1 (https=)
ES (1) ES2900048T3 (https=)
IL (1) IL271628B2 (https=)
MA (1) MA49498A (https=)
PL (1) PL3645535T3 (https=)
PY (1) PY1850855A (https=)
SG (1) SG11201912651WA (https=)
TW (1) TWI750393B (https=)
UY (1) UY37778A (https=)
WO (1) WO2019002454A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025002962A1 (en) 2023-06-30 2025-01-02 Nerviano Medical Sciences S.R.L. Use of a mps1 inhibitor for the treatment of hepatocellular carcinoma
WO2025021587A1 (en) 2023-07-21 2025-01-30 Nerviano Medical Sciences S.R.L. Combination of a mps1 inhibitor and immune checkpoint inhibitors, uses and pharmaceutical compositions thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156315A1 (en) 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156315A1 (en) 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines
JP2011525516A (ja) 2008-06-26 2011-09-22 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ピラゾロ−キナゾリン

Also Published As

Publication number Publication date
EA202090115A1 (ru) 2020-05-25
EA039764B1 (ru) 2022-03-11
US11160806B2 (en) 2021-11-02
CA3068357C (en) 2022-04-19
JP2020525477A (ja) 2020-08-27
WO2019002454A1 (en) 2019-01-03
EP3645535B1 (en) 2021-09-08
PL3645535T3 (pl) 2022-03-21
JP7141416B2 (ja) 2022-09-22
CL2019003848A1 (es) 2020-07-10
KR20200020905A (ko) 2020-02-26
CN110896636A (zh) 2020-03-20
EP3645535A1 (en) 2020-05-06
US20200246339A1 (en) 2020-08-06
PY1850855A (es) 2019-04-01
AU2018293729B2 (en) 2022-03-10
AR112040A1 (es) 2019-09-11
CA3068357A1 (en) 2019-01-03
IL271628A (en) 2020-02-27
CN110896636B (zh) 2022-07-19
ES2900048T3 (es) 2022-03-15
UY37778A (es) 2019-01-31
TWI750393B (zh) 2021-12-21
MA49498A (fr) 2021-05-26
IL271628B2 (en) 2023-07-01
BR112019027924A2 (pt) 2020-08-18
US20240350501A1 (en) 2024-10-24
AU2018293729B9 (en) 2022-07-14
AU2018293729A1 (en) 2020-01-23
TW201904971A (zh) 2019-02-01
IL271628B1 (en) 2023-03-01
SG11201912651WA (en) 2020-01-30
US20220016122A1 (en) 2022-01-20

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