CN110896636B - 抑制mps1激酶的化合物的盐、其制备以及包含它的制剂 - Google Patents

抑制mps1激酶的化合物的盐、其制备以及包含它的制剂 Download PDF

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CN110896636B
CN110896636B CN201880043442.0A CN201880043442A CN110896636B CN 110896636 B CN110896636 B CN 110896636B CN 201880043442 A CN201880043442 A CN 201880043442A CN 110896636 B CN110896636 B CN 110896636B
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cancer
tumors
lymphoma
treatment
compound
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CN110896636A (zh
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M·扎皮耶里
M·卡尔达雷利
I·坎迪安尼
M·达内洛
G·达拉斯摩
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Nerviano Medical Sciences SRL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201880043442.0A 2017-06-29 2018-06-28 抑制mps1激酶的化合物的盐、其制备以及包含它的制剂 Active CN110896636B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305826 2017-06-29
EP17305826.4 2017-06-29
PCT/EP2018/067394 WO2019002454A1 (en) 2017-06-29 2018-06-28 NOVEL N- (2,6-DIETHYLPHENYL) -8 - ({4- [4- (DIMETHYLAMINO) PIPERIDIN-1-YL] -2-METHOXYPHENYL} AMINO) -1-METHYL-4,5-DIHYDRO-1H SALT -PYRAZOLO [4,3-H] QUINAZOLINE-3-CARBOXAMIDE, ITS PREPARATION AND FORMULATIONS CONTAINING THE SAME

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CN110896636A CN110896636A (zh) 2020-03-20
CN110896636B true CN110896636B (zh) 2022-07-19

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US (3) US11160806B2 (https=)
EP (1) EP3645535B1 (https=)
JP (1) JP7141416B2 (https=)
KR (1) KR102609333B1 (https=)
CN (1) CN110896636B (https=)
AR (1) AR112040A1 (https=)
AU (1) AU2018293729B9 (https=)
CA (1) CA3068357C (https=)
CL (1) CL2019003848A1 (https=)
EA (1) EA039764B1 (https=)
ES (1) ES2900048T3 (https=)
IL (1) IL271628B2 (https=)
MA (1) MA49498A (https=)
PL (1) PL3645535T3 (https=)
PY (1) PY1850855A (https=)
SG (1) SG11201912651WA (https=)
TW (1) TWI750393B (https=)
UY (1) UY37778A (https=)
WO (1) WO2019002454A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025002962A1 (en) 2023-06-30 2025-01-02 Nerviano Medical Sciences S.R.L. Use of a mps1 inhibitor for the treatment of hepatocellular carcinoma
WO2025021587A1 (en) 2023-07-21 2025-01-30 Nerviano Medical Sciences S.R.L. Combination of a mps1 inhibitor and immune checkpoint inhibitors, uses and pharmaceutical compositions thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156315A1 (en) * 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156315A1 (en) * 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines

Also Published As

Publication number Publication date
EA202090115A1 (ru) 2020-05-25
EA039764B1 (ru) 2022-03-11
US11160806B2 (en) 2021-11-02
CA3068357C (en) 2022-04-19
JP2020525477A (ja) 2020-08-27
WO2019002454A1 (en) 2019-01-03
EP3645535B1 (en) 2021-09-08
PL3645535T3 (pl) 2022-03-21
JP7141416B2 (ja) 2022-09-22
CL2019003848A1 (es) 2020-07-10
KR20200020905A (ko) 2020-02-26
CN110896636A (zh) 2020-03-20
EP3645535A1 (en) 2020-05-06
US20200246339A1 (en) 2020-08-06
PY1850855A (es) 2019-04-01
AU2018293729B2 (en) 2022-03-10
AR112040A1 (es) 2019-09-11
CA3068357A1 (en) 2019-01-03
IL271628A (en) 2020-02-27
ES2900048T3 (es) 2022-03-15
UY37778A (es) 2019-01-31
KR102609333B1 (ko) 2023-12-01
TWI750393B (zh) 2021-12-21
MA49498A (fr) 2021-05-26
IL271628B2 (en) 2023-07-01
BR112019027924A2 (pt) 2020-08-18
US20240350501A1 (en) 2024-10-24
AU2018293729B9 (en) 2022-07-14
AU2018293729A1 (en) 2020-01-23
TW201904971A (zh) 2019-02-01
IL271628B1 (en) 2023-03-01
SG11201912651WA (en) 2020-01-30
US20220016122A1 (en) 2022-01-20

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