PL3645535T3 - Nowa sól N-(2,6-dietylofenylo)-8-({4-[4-(dimetyloamino)piperydyn-1-ylo]-2-metoksyfenylo}amino)-1-metylo-4,5-dihydro-1H-pirazolo[4,3-h]chinazolino-3-karboksyamidu, jej wytwarzanie oraz kompozycje ją zawierające - Google Patents

Nowa sól N-(2,6-dietylofenylo)-8-({4-[4-(dimetyloamino)piperydyn-1-ylo]-2-metoksyfenylo}amino)-1-metylo-4,5-dihydro-1H-pirazolo[4,3-h]chinazolino-3-karboksyamidu, jej wytwarzanie oraz kompozycje ją zawierające

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Publication number
PL3645535T3
PL3645535T3 PL18732820T PL18732820T PL3645535T3 PL 3645535 T3 PL3645535 T3 PL 3645535T3 PL 18732820 T PL18732820 T PL 18732820T PL 18732820 T PL18732820 T PL 18732820T PL 3645535 T3 PL3645535 T3 PL 3645535T3
Authority
PL
Poland
Prior art keywords
diethylphenyl
pyrazolo
quinazoline
piperidin
carboxamide
Prior art date
Application number
PL18732820T
Other languages
English (en)
Polish (pl)
Inventor
Massimo Zampieri
Marina Caldarelli
Ilaria Candiani
Matteo D'anello
Germano D'arasmo
Original Assignee
Nerviano Medical Sciences S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences S.R.L. filed Critical Nerviano Medical Sciences S.R.L.
Publication of PL3645535T3 publication Critical patent/PL3645535T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/42Phosphorus; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL18732820T 2017-06-29 2018-06-28 Nowa sól N-(2,6-dietylofenylo)-8-({4-[4-(dimetyloamino)piperydyn-1-ylo]-2-metoksyfenylo}amino)-1-metylo-4,5-dihydro-1H-pirazolo[4,3-h]chinazolino-3-karboksyamidu, jej wytwarzanie oraz kompozycje ją zawierające PL3645535T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305826 2017-06-29
PCT/EP2018/067394 WO2019002454A1 (en) 2017-06-29 2018-06-28 NOVEL N- (2,6-DIETHYLPHENYL) -8 - ({4- [4- (DIMETHYLAMINO) PIPERIDIN-1-YL] -2-METHOXYPHENYL} AMINO) -1-METHYL-4,5-DIHYDRO-1H SALT -PYRAZOLO [4,3-H] QUINAZOLINE-3-CARBOXAMIDE, ITS PREPARATION AND FORMULATIONS CONTAINING THE SAME
EP18732820.8A EP3645535B1 (en) 2017-06-29 2018-06-28 New salt of n-(2,6-diethylphenyl)-8-({4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}amino)-1-methyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide, its preparation and formulations containing it

Publications (1)

Publication Number Publication Date
PL3645535T3 true PL3645535T3 (pl) 2022-03-21

Family

ID=59313166

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18732820T PL3645535T3 (pl) 2017-06-29 2018-06-28 Nowa sól N-(2,6-dietylofenylo)-8-({4-[4-(dimetyloamino)piperydyn-1-ylo]-2-metoksyfenylo}amino)-1-metylo-4,5-dihydro-1H-pirazolo[4,3-h]chinazolino-3-karboksyamidu, jej wytwarzanie oraz kompozycje ją zawierające

Country Status (19)

Country Link
US (3) US11160806B2 (https=)
EP (1) EP3645535B1 (https=)
JP (1) JP7141416B2 (https=)
KR (1) KR102609333B1 (https=)
CN (1) CN110896636B (https=)
AR (1) AR112040A1 (https=)
AU (1) AU2018293729B9 (https=)
CA (1) CA3068357C (https=)
CL (1) CL2019003848A1 (https=)
EA (1) EA039764B1 (https=)
ES (1) ES2900048T3 (https=)
IL (1) IL271628B2 (https=)
MA (1) MA49498A (https=)
PL (1) PL3645535T3 (https=)
PY (1) PY1850855A (https=)
SG (1) SG11201912651WA (https=)
TW (1) TWI750393B (https=)
UY (1) UY37778A (https=)
WO (1) WO2019002454A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025002962A1 (en) 2023-06-30 2025-01-02 Nerviano Medical Sciences S.R.L. Use of a mps1 inhibitor for the treatment of hepatocellular carcinoma
WO2025021587A1 (en) 2023-07-21 2025-01-30 Nerviano Medical Sciences S.R.L. Combination of a mps1 inhibitor and immune checkpoint inhibitors, uses and pharmaceutical compositions thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010013843A (es) 2008-06-26 2011-01-21 Nerviano Medical Sciences Srl Pirazolo-quinazolinas.

Also Published As

Publication number Publication date
EA202090115A1 (ru) 2020-05-25
EA039764B1 (ru) 2022-03-11
US11160806B2 (en) 2021-11-02
CA3068357C (en) 2022-04-19
JP2020525477A (ja) 2020-08-27
WO2019002454A1 (en) 2019-01-03
EP3645535B1 (en) 2021-09-08
JP7141416B2 (ja) 2022-09-22
CL2019003848A1 (es) 2020-07-10
KR20200020905A (ko) 2020-02-26
CN110896636A (zh) 2020-03-20
EP3645535A1 (en) 2020-05-06
US20200246339A1 (en) 2020-08-06
PY1850855A (es) 2019-04-01
AU2018293729B2 (en) 2022-03-10
AR112040A1 (es) 2019-09-11
CA3068357A1 (en) 2019-01-03
IL271628A (en) 2020-02-27
CN110896636B (zh) 2022-07-19
ES2900048T3 (es) 2022-03-15
UY37778A (es) 2019-01-31
KR102609333B1 (ko) 2023-12-01
TWI750393B (zh) 2021-12-21
MA49498A (fr) 2021-05-26
IL271628B2 (en) 2023-07-01
BR112019027924A2 (pt) 2020-08-18
US20240350501A1 (en) 2024-10-24
AU2018293729B9 (en) 2022-07-14
AU2018293729A1 (en) 2020-01-23
TW201904971A (zh) 2019-02-01
IL271628B1 (en) 2023-03-01
SG11201912651WA (en) 2020-01-30
US20220016122A1 (en) 2022-01-20

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