KR102607220B1 - 종양 선택적 tata-박스 및 caat-박스 돌연변이체 - Google Patents

종양 선택적 tata-박스 및 caat-박스 돌연변이체 Download PDF

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KR102607220B1
KR102607220B1 KR1020197025497A KR20197025497A KR102607220B1 KR 102607220 B1 KR102607220 B1 KR 102607220B1 KR 1020197025497 A KR1020197025497 A KR 1020197025497A KR 20197025497 A KR20197025497 A KR 20197025497A KR 102607220 B1 KR102607220 B1 KR 102607220B1
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토니 알. 레이드
브라이언 티. 오론스키
파라 헤드란
크리스토퍼 라슨
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에피센트알엑스, 인코포레이티드
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KR1020197025497A 2017-01-30 2018-01-30 종양 선택적 tata-박스 및 caat-박스 돌연변이체 Active KR102607220B1 (ko)

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US201762452075P 2017-01-30 2017-01-30
US62/452,075 2017-01-30
PCT/US2018/016025 WO2018140970A1 (en) 2017-01-30 2018-01-30 Tumor selective tata-box and caat-box mutants

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KR1020237040310A Active KR102880548B1 (ko) 2017-01-30 2018-01-30 종양 선택적 tata-박스 및 caat-박스 돌연변이체

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CN (1) CN110741081B (enExample)
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Families Citing this family (7)

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CA2903582C (en) 2013-03-14 2021-06-08 Salk Institute For Biological Studies Oncolytic adenovirus compositions
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CA3045892A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
EP3610003A4 (en) 2017-04-10 2021-01-06 EpicentRx, Inc. RECOMBINANT VIRUS PRODUCTION PROCESS
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
EP4554559A1 (en) 2022-07-13 2025-05-21 EpicentRx, Inc. Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010086838A2 (en) * 2009-02-02 2010-08-05 Oncos Therapeutics Non-ad5 adenoviral vectors and methods and uses related thereto
WO2010101921A2 (en) * 2009-03-02 2010-09-10 The Regents Of The University Of California Tumor-selective e1a and e1b mutants

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1190901A (en) * 1999-09-30 2001-04-30 Trustees Of The University Of Pennsylvania, The Replication selective adenoviruses for use in cancer therapy
EP1381276A4 (en) * 2001-04-13 2005-02-02 Univ Pennsylvania METHOD FOR TREATMENT OR DEVELOPMENT SLUDGE DEGRADATION
CN1597939A (zh) * 2001-11-15 2005-03-23 杭州中肽生化有限公司 多功能抗癌重组腺病毒
CN101319215B (zh) * 2008-07-01 2010-12-22 郑骏年 人肿瘤特异性Ki67基因启动子
KR101427200B1 (ko) * 2011-11-24 2014-08-07 주식회사 바이로메드 아데노바이러스 생산 신규 세포주 및 그의 용도
FI123955B (en) * 2011-11-25 2014-01-15 Oncos Therapeutics Ltd Oncolytic adenovirus
US20140350087A9 (en) * 2012-03-22 2014-11-27 Halozyme, Inc. Oncovector Nucleic Acid Molecules and Methods of Use
JP6895374B2 (ja) 2014-07-16 2021-06-30 トランジェーヌTransgene 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス
CN120796389A (zh) * 2017-05-26 2025-10-17 埃皮森特Rx股份有限公司 携带转基因的重组腺病毒

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010086838A2 (en) * 2009-02-02 2010-08-05 Oncos Therapeutics Non-ad5 adenoviral vectors and methods and uses related thereto
WO2010101921A2 (en) * 2009-03-02 2010-09-10 The Regents Of The University Of California Tumor-selective e1a and e1b mutants

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Cancer Gene Therapy, 2011, vol. 18, pages 717-723.*
Molecular and Cellular Biology, 1987, vol. 7, pages 2578-2587.*
Molecular and Cellular Biology, 1988, vol. 8, pages 353-360.*

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KR20190128633A (ko) 2019-11-18
EA201991806A1 (ru) 2020-02-13
KR102880548B1 (ko) 2025-11-05
CN110741081B (zh) 2024-07-23
ZA201905070B (en) 2024-12-18
AU2018212017A1 (en) 2019-08-15
JP7242534B2 (ja) 2023-03-20
EP3573632C0 (en) 2024-08-07
WO2018140970A1 (en) 2018-08-02
BR112019015514A2 (pt) 2020-04-07
EP3573632B1 (en) 2024-08-07
AU2018212017B2 (en) 2024-11-28
EP3573632A4 (en) 2020-09-23
JP2020505046A (ja) 2020-02-20
CA3052086A1 (en) 2018-08-02
EP3573632A1 (en) 2019-12-04
IL268289B1 (en) 2025-05-01
SG11201906976YA (en) 2019-08-27
IL268289A (en) 2019-09-26
IL268289B2 (en) 2025-09-01
KR20230164231A (ko) 2023-12-01
US20190352669A1 (en) 2019-11-21
CN110741081A (zh) 2020-01-31
MX2019008922A (es) 2020-01-20

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