JP7242534B2 - 腫瘍選択的なｔａｔａボックスおよびｃａａｔボックスの変異体 - Google Patents

腫瘍選択的なｔａｔａボックスおよびｃａａｔボックスの変異体 Download PDF

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JP7242534B2
JP7242534B2 JP2019541082A JP2019541082A JP7242534B2 JP 7242534 B2 JP7242534 B2 JP 7242534B2 JP 2019541082 A JP2019541082 A JP 2019541082A JP 2019541082 A JP2019541082 A JP 2019541082A JP 7242534 B2 JP7242534 B2 JP 7242534B2
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cancer
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cells
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JP2020505046A (ja
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アール． リード，トニー
ティー． オロンスキー，ブライアン
ヘジラン，ファラー
ラーソン，クリストファー
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エピセントアールエックス，インコーポレイテッド
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JP2019541082A 2017-01-30 2018-01-30 腫瘍選択的なｔａｔａボックスおよびｃａａｔボックスの変異体 Active JP7242534B2 (ja)

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US201762452075P 2017-01-30 2017-01-30
US62/452,075 2017-01-30
PCT/US2018/016025 WO2018140970A1 (en) 2017-01-30 2018-01-30 Tumor selective tata-box and caat-box mutants

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JP7242534B2 true JP7242534B2 (ja) 2023-03-20

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US (1) US20190352669A1 (enExample)
EP (1) EP3573632B1 (enExample)
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KR (2) KR102607220B1 (enExample)
CN (1) CN110741081B (enExample)
AU (1) AU2018212017B2 (enExample)
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CA2903582C (en) 2013-03-14 2021-06-08 Salk Institute For Biological Studies Oncolytic adenovirus compositions
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CA3045892A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
EP3610003A4 (en) 2017-04-10 2021-01-06 EpicentRx, Inc. RECOMBINANT VIRUS PRODUCTION PROCESS
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
EP4554559A1 (en) 2022-07-13 2025-05-21 EpicentRx, Inc. Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012519014A (ja) 2009-03-02 2012-08-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体
WO2013076374A1 (en) 2011-11-25 2013-05-30 Oncos Therapeutics Ltd. Recombinant serotype 5 (ac!5) adenoviral vectors
WO2016008976A1 (en) 2014-07-16 2016-01-21 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1190901A (en) * 1999-09-30 2001-04-30 Trustees Of The University Of Pennsylvania, The Replication selective adenoviruses for use in cancer therapy
EP1381276A4 (en) * 2001-04-13 2005-02-02 Univ Pennsylvania METHOD FOR TREATMENT OR DEVELOPMENT SLUDGE DEGRADATION
CN1597939A (zh) * 2001-11-15 2005-03-23 杭州中肽生化有限公司 多功能抗癌重组腺病毒
CN101319215B (zh) * 2008-07-01 2010-12-22 郑骏年 人肿瘤特异性Ki67基因启动子
FI20090030A0 (fi) * 2009-02-02 2009-02-02 Akseli Eetu Hemminki Onkolyyttiset virukset
KR101427200B1 (ko) * 2011-11-24 2014-08-07 주식회사 바이로메드 아데노바이러스 생산 신규 세포주 및 그의 용도
US20140350087A9 (en) * 2012-03-22 2014-11-27 Halozyme, Inc. Oncovector Nucleic Acid Molecules and Methods of Use
CN120796389A (zh) * 2017-05-26 2025-10-17 埃皮森特Rx股份有限公司 携带转基因的重组腺病毒

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012519014A (ja) 2009-03-02 2012-08-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体
WO2013076374A1 (en) 2011-11-25 2013-05-30 Oncos Therapeutics Ltd. Recombinant serotype 5 (ac!5) adenoviral vectors
WO2016008976A1 (en) 2014-07-16 2016-01-21 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
He, T. C. et al.，A simplified system for generating recombinant adenoviruses，Proc. Natl. Acad. Sci. U. S. A.，1998年，Vol. 95(5)，pp. 2509-2514
Hearing, P. et al.，The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element，Cell，1983年，Vol. 33(3)，pp. 695 -703
Hedjran, F. et al.，Deletion analysis of Ad5 Ela transcriptional control region: impact on tumor-selective expression of Ela and Elb，CANCER GENE THERAPY，2011年，Vol. 18，pp. 717 - 723
Xing L et al.，E1A promoter of bovine adenovirus type 3，J. Gen. Virol.，2006年，Vol. 87(12)，pp. 3539-3544
Yamamoto, M. et al.，Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with E1 deleted，J. Virol.，2003年，Vol. 77(2)，pp. 1633-1637
半田 宏，アデノウイルス転写の機構，ウイルス，1987年，Vol. 37(2)，pp. 229-240
小澤 敬也，アデノ随伴ウイルス(AAV)ベクターによる遺伝子治療，ウイルス，2003年，Vol. 53(2)，pp. 163-170
西山 幸廣 ほか，単純ヘルペスウイルスを利用した癌に対するウイルス療法，ウイルス，2007年，Vol. 57(1)，pp. 57-66

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EA201991806A1 (ru) 2020-02-13
KR102880548B1 (ko) 2025-11-05
CN110741081B (zh) 2024-07-23
ZA201905070B (en) 2024-12-18
AU2018212017A1 (en) 2019-08-15
EP3573632C0 (en) 2024-08-07
WO2018140970A1 (en) 2018-08-02
BR112019015514A2 (pt) 2020-04-07
EP3573632B1 (en) 2024-08-07
AU2018212017B2 (en) 2024-11-28
EP3573632A4 (en) 2020-09-23
JP2020505046A (ja) 2020-02-20
CA3052086A1 (en) 2018-08-02
EP3573632A1 (en) 2019-12-04
IL268289B1 (en) 2025-05-01
SG11201906976YA (en) 2019-08-27
IL268289A (en) 2019-09-26
IL268289B2 (en) 2025-09-01
KR20230164231A (ko) 2023-12-01
KR102607220B1 (ko) 2023-12-01
US20190352669A1 (en) 2019-11-21
CN110741081A (zh) 2020-01-31
MX2019008922A (es) 2020-01-20

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