KR102591886B1 - 축합고리 피리미딘계 화합물, 중간체, 이의 제조 방법, 조성물 및 응용 - Google Patents

축합고리 피리미딘계 화합물, 중간체, 이의 제조 방법, 조성물 및 응용 Download PDF

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KR102591886B1
KR102591886B1 KR1020187004890A KR20187004890A KR102591886B1 KR 102591886 B1 KR102591886 B1 KR 102591886B1 KR 1020187004890 A KR1020187004890 A KR 1020187004890A KR 20187004890 A KR20187004890 A KR 20187004890A KR 102591886 B1 KR102591886 B1 KR 102591886B1
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KR20180028521A (ko
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주셩 슈
농 장
팅한 왕
칭루이 선
유구앙 왕
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광저우 맥시노벨 파마수티컬스 씨오., 엘티디.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K9/10—Dispersions; Emulsions
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020187004890A 2015-07-21 2016-07-21 축합고리 피리미딘계 화합물, 중간체, 이의 제조 방법, 조성물 및 응용 Active KR102591886B1 (ko)

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CN201510430641 2015-07-21
CN201510430641.5 2015-07-21
PCT/CN2016/090798 WO2017012559A1 (zh) 2015-07-21 2016-07-21 稠环嘧啶类化合物、中间体、其制备方法、组合物和应用

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KR102591886B1 true KR102591886B1 (ko) 2023-10-20

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US (1) US10494378B2 (https=)
EP (1) EP3354653B1 (https=)
JP (1) JP6875372B2 (https=)
KR (1) KR102591886B1 (https=)
CN (1) CN106366093B (https=)
AU (1) AU2016295594B2 (https=)
CA (1) CA2993096C (https=)
MX (1) MX379383B (https=)
RU (1) RU2732576C2 (https=)
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WO2021148010A1 (zh) * 2020-01-22 2021-07-29 南京明德新药研发有限公司 吡唑并杂芳环类化合物及其应用
US12473300B2 (en) * 2020-03-06 2025-11-18 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Thienopyrimidine derivative and preparation method therefor
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CN117618436A (zh) * 2022-08-25 2024-03-01 广州再极医药科技有限公司 一种稠环嘧啶类化合物的用途
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RU2018103332A3 (https=) 2019-12-09
US10494378B2 (en) 2019-12-03
CN106366093A (zh) 2017-02-01
AU2016295594B2 (en) 2020-04-16
CA2993096C (en) 2022-04-12
RU2018103332A (ru) 2019-08-21
CA2993096A1 (en) 2017-01-26
US20180208604A1 (en) 2018-07-26
KR20180028521A (ko) 2018-03-16
EP3354653B1 (en) 2019-09-04
CN106366093B (zh) 2020-08-18
EP3354653A4 (en) 2018-08-29
NZ739940A (en) 2023-09-29
MX2018000945A (es) 2018-11-09
MX379383B (es) 2025-03-10
EP3354653A1 (en) 2018-08-01
JP2018520202A (ja) 2018-07-26
AU2016295594A1 (en) 2018-03-15
WO2017012559A1 (zh) 2017-01-26
BR112018001209A2 (pt) 2018-09-18
JP6875372B2 (ja) 2021-05-26

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