KR102590466B1 - Cblb 엔도뉴클레아제 변이체, 조성물 및 사용 방법 - Google Patents

Cblb 엔도뉴클레아제 변이체, 조성물 및 사용 방법 Download PDF

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KR102590466B1
KR102590466B1 KR1020197036681A KR20197036681A KR102590466B1 KR 102590466 B1 KR102590466 B1 KR 102590466B1 KR 1020197036681 A KR1020197036681 A KR 1020197036681A KR 20197036681 A KR20197036681 A KR 20197036681A KR 102590466 B1 KR102590466 B1 KR 102590466B1
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polypeptide
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KR20200011953A (ko
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조던 자르주르
카일 헤이븐스
앤-레이첼 크로스택
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2세븐티 바이오, 인코포레이티드
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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KR1020197036681A 2017-05-25 2018-05-25 Cblb 엔도뉴클레아제 변이체, 조성물 및 사용 방법 Active KR102590466B1 (ko)

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KR1020237034961A KR102742817B1 (ko) 2017-05-25 2018-05-25 Cblb 엔도뉴클레아제 변이체, 조성물 및 사용 방법

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US201762511194P 2017-05-25 2017-05-25
US62/511,194 2017-05-25
US201762567417P 2017-10-03 2017-10-03
US62/567,417 2017-10-03
PCT/US2018/034726 WO2018218194A1 (en) 2017-05-25 2018-05-25 Cblb endonuclease variants, compositions, and methods of use

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KR102590466B1 true KR102590466B1 (ko) 2023-10-19

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KR1020237034961A Active KR102742817B1 (ko) 2017-05-25 2018-05-25 Cblb 엔도뉴클레아제 변이체, 조성물 및 사용 방법

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US (4) US12227740B2 (enExample)
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IL270776B2 (en) 2017-05-25 2024-11-01 Bluebird Bio Inc Cblb endonuclease variants, compositions, and methods of use
EP3806903B1 (en) * 2018-06-14 2024-02-14 2seventy bio, Inc. Cd79a chimeric antigen receptors
WO2020072059A1 (en) 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
US20220177860A1 (en) * 2018-12-10 2022-06-09 2Seventy Bio, Inc. Pdcd-1 homing endonuclease variants
KR20210102925A (ko) * 2018-12-10 2021-08-20 블루버드 바이오, 인코포레이티드. 호밍 엔도뉴클레아제 변이체
US20240034768A1 (en) * 2018-12-14 2024-02-01 2Seventy Bio, Inc. Dimerizing agent regulated immunoreceptor complexes
BR112021025259A2 (pt) * 2019-06-14 2022-03-15 2Seventy Bio Inc Composições e métodos para tratar câncer
WO2022020242A1 (en) 2020-07-20 2022-01-27 Enanta Pharmaceuticals, Inc. Functionalized peptides as antiviral agents
US11352363B1 (en) 2020-11-23 2022-06-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2022109360A1 (en) 2020-11-23 2022-05-27 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US11384090B2 (en) 2020-11-23 2022-07-12 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
EP4262850A4 (en) * 2020-12-21 2025-07-09 Novo Nordisk As COMPOSITIONS AND METHODS FOR SITE-DIRECTED MUTAGENESIS
US11319325B1 (en) 2021-05-11 2022-05-03 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
US11325916B1 (en) 2021-07-29 2022-05-10 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11339170B1 (en) 2021-07-23 2022-05-24 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents

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WO2017001572A1 (en) * 2015-06-30 2017-01-05 Cellectis Methods for improving functionality in nk cell by gene inactivation using specific endonuclease

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