JP7191042B2 - Ｃｂｌｂエンドヌクレアーゼバリアント、組成物、および使用方法 - Google Patents

Ｃｂｌｂエンドヌクレアーゼバリアント、組成物、および使用方法 Download PDF

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JP7191042B2
JP7191042B2 JP2019564937A JP2019564937A JP7191042B2 JP 7191042 B2 JP7191042 B2 JP 7191042B2 JP 2019564937 A JP2019564937 A JP 2019564937A JP 2019564937 A JP2019564937 A JP 2019564937A JP 7191042 B2 JP7191042 B2 JP 7191042B2
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polypeptide
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cells
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JP2020521456A5 (enExample
JP2020521456A (ja
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ジョーダン ジャージョル，
カイル ヘイヴンズ，
アン－レイチェル クロスタグ，
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２セブンティ バイオ インコーポレイテッド
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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JP2019564937A 2017-05-25 2018-05-25 Ｃｂｌｂエンドヌクレアーゼバリアント、組成物、および使用方法 Active JP7191042B2 (ja)

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JP2022166786A JP7450683B2 (ja) 2017-05-25 2022-10-18 Ｃｂｌｂエンドヌクレアーゼバリアント、組成物、および使用方法
JP2024032998A JP2024055980A (ja) 2017-05-25 2024-03-05 Ｃｂｌｂエンドヌクレアーゼバリアント、組成物、および使用方法

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US201762511194P 2017-05-25 2017-05-25
US62/511,194 2017-05-25
US201762567417P 2017-10-03 2017-10-03
US62/567,417 2017-10-03
PCT/US2018/034726 WO2018218194A1 (en) 2017-05-25 2018-05-25 Cblb endonuclease variants, compositions, and methods of use

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MA48797A (fr) 2017-05-25 2020-04-08 Bluebird Bio Inc Variants de l'endonucléase cblb , compositions et procédés d'utilisation
EP3806903B1 (en) 2018-06-14 2024-02-14 2seventy bio, Inc. Cd79a chimeric antigen receptors
WO2020072059A1 (en) 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
EP3893886A4 (en) * 2018-12-10 2022-09-28 2seventy bio, Inc. Pdcd-1 homing endonuclease variants
KR20210102925A (ko) 2018-12-10 2021-08-20 블루버드 바이오, 인코포레이티드. 호밍 엔도뉴클레아제 변이체
US20240034768A1 (en) * 2018-12-14 2024-02-01 2Seventy Bio, Inc. Dimerizing agent regulated immunoreceptor complexes
MA56212A (fr) * 2019-06-14 2022-04-20 2Seventy Bio Inc Compositions et méthodes de traitement du cancer
HUE21846991T1 (hu) 2020-07-20 2022-09-28 Enanta Pharm Inc Vírusellenes funkcionalizált peptid szerek
US11384090B2 (en) 2020-11-23 2022-07-12 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
JP2024500286A (ja) 2020-11-23 2024-01-09 エナンタ ファーマシューティカルズ インコーポレイテッド 新規スピロピロリジン誘導抗ウイルス剤
US11352363B1 (en) 2020-11-23 2022-06-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
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