CN110799644A - Cblb核酸内切酶变体、组合物及使用方法 - Google Patents

Cblb核酸内切酶变体、组合物及使用方法 Download PDF

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Publication number
CN110799644A
CN110799644A CN201880042211.8A CN201880042211A CN110799644A CN 110799644 A CN110799644 A CN 110799644A CN 201880042211 A CN201880042211 A CN 201880042211A CN 110799644 A CN110799644 A CN 110799644A
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polypeptide
cell
seq
amino acid
biologically active
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乔丹·贾儒尔
凯尔·哈文斯
安妮-瑞秋·克罗斯塔格
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Regeneron Pharmaceuticals Inc
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Bluebird Bio Inc
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CN201880042211.8A 2017-05-25 2018-05-25 Cblb核酸内切酶变体、组合物及使用方法 Pending CN110799644A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762511194P 2017-05-25 2017-05-25
US62/511,194 2017-05-25
US201762567417P 2017-10-03 2017-10-03
US62/567,417 2017-10-03
PCT/US2018/034726 WO2018218194A1 (en) 2017-05-25 2018-05-25 Cblb endonuclease variants, compositions, and methods of use

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CN110799644A true CN110799644A (zh) 2020-02-14

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US (4) US12227740B2 (enExample)
EP (1) EP3630962A4 (enExample)
JP (3) JP7191042B2 (enExample)
KR (2) KR102590466B1 (enExample)
CN (1) CN110799644A (enExample)
AU (2) AU2018273979B2 (enExample)
CA (1) CA3064014A1 (enExample)
IL (2) IL270776B2 (enExample)
MA (1) MA48797A (enExample)
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MA48797A (fr) 2017-05-25 2020-04-08 Bluebird Bio Inc Variants de l'endonucléase cblb , compositions et procédés d'utilisation
EP3806903B1 (en) 2018-06-14 2024-02-14 2seventy bio, Inc. Cd79a chimeric antigen receptors
WO2020072059A1 (en) 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
EP3893886A4 (en) * 2018-12-10 2022-09-28 2seventy bio, Inc. Pdcd-1 homing endonuclease variants
KR20210102925A (ko) 2018-12-10 2021-08-20 블루버드 바이오, 인코포레이티드. 호밍 엔도뉴클레아제 변이체
US20240034768A1 (en) * 2018-12-14 2024-02-01 2Seventy Bio, Inc. Dimerizing agent regulated immunoreceptor complexes
MA56212A (fr) * 2019-06-14 2022-04-20 2Seventy Bio Inc Compositions et méthodes de traitement du cancer
HUE21846991T1 (hu) 2020-07-20 2022-09-28 Enanta Pharm Inc Vírusellenes funkcionalizált peptid szerek
US11384090B2 (en) 2020-11-23 2022-07-12 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
JP2024500286A (ja) 2020-11-23 2024-01-09 エナンタ ファーマシューティカルズ インコーポレイテッド 新規スピロピロリジン誘導抗ウイルス剤
US11352363B1 (en) 2020-11-23 2022-06-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US20240336904A1 (en) * 2020-12-21 2024-10-10 2Seventy Bio, Inc. Compositions and methods for site-directed mutagenesis
US11319325B1 (en) 2021-05-11 2022-05-03 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
US11325916B1 (en) 2021-07-29 2022-05-10 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11339170B1 (en) 2021-07-23 2022-05-24 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents

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US20140148361A1 (en) * 2010-06-07 2014-05-29 Barry L. Stoddard Generation and Expression of Engineered I-ONUI Endonuclease and Its Homologues and Uses Thereof
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