KR102586710B1 - C5a 억제제로서의 5-5 융합 고리 - Google Patents
C5a 억제제로서의 5-5 융합 고리 Download PDFInfo
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- KR102586710B1 KR102586710B1 KR1020197038670A KR20197038670A KR102586710B1 KR 102586710 B1 KR102586710 B1 KR 102586710B1 KR 1020197038670 A KR1020197038670 A KR 1020197038670A KR 20197038670 A KR20197038670 A KR 20197038670A KR 102586710 B1 KR102586710 B1 KR 102586710B1
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- ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Liquid Crystal Substances (AREA)
- Glass Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Insulating Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US201762513025P | 2017-05-31 | 2017-05-31 | |
| US62/513,025 | 2017-05-31 | ||
| PCT/US2018/034908 WO2018222601A1 (en) | 2017-05-31 | 2018-05-29 | 5-5 FUSED RINGS AS C5a INHIBITORS |
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| KR20200013720A KR20200013720A (ko) | 2020-02-07 |
| KR102586710B1 true KR102586710B1 (ko) | 2023-10-10 |
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| WO (1) | WO2018222601A1 (cg-RX-API-DMAC7.html) |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110997674B (zh) | 2017-05-31 | 2022-12-20 | 凯莫森特里克斯股份有限公司 | 作为C5a抑制剂的6-5稠合环类 |
| US10683294B2 (en) | 2017-05-31 | 2020-06-16 | Chemocentryx, Inc. | 5-5 fused rings as C5a inhibitors |
| KR102852027B1 (ko) | 2017-12-22 | 2025-08-27 | 케모센트릭스, 인크. | C5aR 억제제로서의 디아릴 치환된 5,5-융합 고리 화합물 |
| ES2980175T3 (es) * | 2017-12-22 | 2024-09-30 | Chemocentryx Inc | Compuestos anulares fusionados en 6,5 sustituidos con diarilo como inhibidores de C5aR |
| CN111954525B (zh) * | 2018-04-02 | 2023-12-26 | 凯莫森特里克斯股份有限公司 | 稠合双环C5aR拮抗剂的前药 |
| CN114206338B (zh) | 2019-07-10 | 2025-12-12 | 凯莫森特里克斯股份有限公司 | 作为pd-l1抑制剂的二氢化茚类 |
| CN112300169B (zh) * | 2019-07-26 | 2022-03-04 | 上海美迪西生物医药股份有限公司 | 吡咯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| PH12022550877A1 (en) | 2019-10-16 | 2023-03-27 | Chemocentryx Inc | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases |
| US11713307B2 (en) | 2019-10-16 | 2023-08-01 | Chemocentryx, Inc. | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases |
| EP4219453A4 (en) * | 2020-09-28 | 2024-10-09 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | PYRAZOLE COMPOUND AND ITS PREPARATION METHOD AND ITS USE |
| JP2023548117A (ja) | 2020-10-28 | 2023-11-15 | ケモセントリックス， インコーポレイテッド | 化膿性汗腺炎を処置する方法 |
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| SE524438C2 (sv) | 2000-10-05 | 2004-08-10 | Magnus Georg Goertz | Fjärrstyrt dörrelaterat låsarrangemang, första och andra datorpogramprodukt, bärande medium och ett datorlösbart medium |
| JP4196678B2 (ja) | 2001-04-26 | 2008-12-17 | 味の素株式会社 | 複素環化合物 |
| ITMI20012025A1 (it) | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
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| ES2980175T3 (es) | 2017-12-22 | 2024-09-30 | Chemocentryx Inc | Compuestos anulares fusionados en 6,5 sustituidos con diarilo como inhibidores de C5aR |
| KR102852027B1 (ko) | 2017-12-22 | 2025-08-27 | 케모센트릭스, 인크. | C5aR 억제제로서의 디아릴 치환된 5,5-융합 고리 화합물 |
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| WO2006042102A2 (en) | 2004-10-05 | 2006-04-20 | Neurogen Corporation | Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds |
| US20070112015A1 (en) | 2005-10-28 | 2007-05-17 | Chemocentryx, Inc. | Substituted dihydropyridines and methods of use |
| JP2014521607A (ja) | 2011-07-22 | 2014-08-28 | ノバルティス アーゲー | テトラヒドロピリド−ピリジンおよびテトラヒドロピリド−ピリミジン化合物およびＣ５ａ受容体モジュレーターとしてのその使用 |
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| CN111032658A (zh) | 2020-04-17 |
| TWI813570B (zh) | 2023-09-01 |
| JP2020522483A (ja) | 2020-07-30 |
| TW201902897A (zh) | 2019-01-16 |
| US20180346471A1 (en) | 2018-12-06 |
| AR111841A1 (es) | 2019-08-21 |
| MX391392B (es) | 2025-03-21 |
| US20210009594A1 (en) | 2021-01-14 |
| AU2018277523B2 (en) | 2022-06-23 |
| IL270842B2 (en) | 2023-05-01 |
| MX2019014292A (es) | 2022-04-07 |
| CA3064025A1 (en) | 2018-12-06 |
| ES2934507T3 (es) | 2023-02-22 |
| EP3630774A4 (en) | 2020-10-07 |
| MA48800A (fr) | 2020-04-08 |
| BR112019025230A2 (pt) | 2020-06-16 |
| CN111032658B (zh) | 2022-12-20 |
| KR20200013720A (ko) | 2020-02-07 |
| JP7141129B2 (ja) | 2022-09-22 |
| WO2018222601A1 (en) | 2018-12-06 |
| ZA201907755B (en) | 2023-05-31 |
| IL270842B1 (en) | 2023-01-01 |
| US10683294B2 (en) | 2020-06-16 |
| AU2018277523A1 (en) | 2019-12-05 |
| IL270842A (en) | 2020-01-30 |
| RU2019142985A (ru) | 2021-06-30 |
| EP3630774B1 (en) | 2022-11-23 |
| US11479553B2 (en) | 2022-10-25 |
| EP3630774A1 (en) | 2020-04-08 |
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