KR102578256B1 - 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질 - Google Patents

친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질 Download PDF

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KR102578256B1
KR102578256B1 KR1020197003790A KR20197003790A KR102578256B1 KR 102578256 B1 KR102578256 B1 KR 102578256B1 KR 1020197003790 A KR1020197003790 A KR 1020197003790A KR 20197003790 A KR20197003790 A KR 20197003790A KR 102578256 B1 KR102578256 B1 KR 102578256B1
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protein
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gln
leu
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파울 크니크
에리크 피틀러
울리히 하우프츠
마렌 마이징
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리플리겐 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
KR1020197003790A 2016-08-11 2017-08-07 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질 Active KR102578256B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237030862A KR20230133943A (ko) 2016-08-11 2017-08-07 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16183710.9 2016-08-11
EP16183710 2016-08-11
EP16205707 2016-12-21
EP16205707.9 2016-12-21
PCT/EP2017/069979 WO2018029158A1 (en) 2016-08-11 2017-08-07 Alkaline stable fc—binding proteins for affinity chromatography

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KR1020237030862A Division KR20230133943A (ko) 2016-08-11 2017-08-07 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질

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KR20190038560A KR20190038560A (ko) 2019-04-08
KR102578256B1 true KR102578256B1 (ko) 2023-09-15

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KR1020197003790A Active KR102578256B1 (ko) 2016-08-11 2017-08-07 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질
KR1020237030862A Pending KR20230133943A (ko) 2016-08-11 2017-08-07 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질
KR1020197003966A Active KR102573370B1 (ko) 2016-08-11 2017-08-07 신규한 알칼리 안정성 면역글로불린 결합 단백질

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KR1020197003966A Active KR102573370B1 (ko) 2016-08-11 2017-08-07 신규한 알칼리 안정성 면역글로불린 결합 단백질

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US (4) US11230576B2 (https=)
EP (4) EP3497117B1 (https=)
JP (3) JP7181612B2 (https=)
KR (3) KR102578256B1 (https=)
CN (4) CN109963864B (https=)
AU (2) AU2017311542B2 (https=)
CA (2) CA3030208A1 (https=)
DK (1) DK3497117T5 (https=)
LT (1) LT3497117T (https=)
SG (1) SG11201901066UA (https=)
WO (2) WO2018029158A1 (https=)

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