DK3497117T5 - Nye alkalisk stabile immunglobulin-bindende proteiner - Google Patents
Nye alkalisk stabile immunglobulin-bindende proteiner Download PDFInfo
- Publication number
- DK3497117T5 DK3497117T5 DK17752349.5T DK17752349T DK3497117T5 DK 3497117 T5 DK3497117 T5 DK 3497117T5 DK 17752349 T DK17752349 T DK 17752349T DK 3497117 T5 DK3497117 T5 DK 3497117T5
- Authority
- DK
- Denmark
- Prior art keywords
- immunglobulin
- stable
- binding proteins
- new alkaline
- alkaline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183710 | 2016-08-11 | ||
| EP16205707 | 2016-12-21 | ||
| PCT/EP2017/069976 WO2018029157A1 (en) | 2016-08-11 | 2017-08-07 | Novel alkaline stable immunoglobulin-binding proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3497117T3 DK3497117T3 (da) | 2024-04-22 |
| DK3497117T5 true DK3497117T5 (da) | 2024-09-02 |
Family
ID=59631752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17752349.5T DK3497117T5 (da) | 2016-08-11 | 2017-08-07 | Nye alkalisk stabile immunglobulin-bindende proteiner |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11230576B2 (https=) |
| EP (4) | EP3497117B1 (https=) |
| JP (3) | JP7181612B2 (https=) |
| KR (3) | KR102578256B1 (https=) |
| CN (4) | CN109963864B (https=) |
| AU (2) | AU2017311542B2 (https=) |
| CA (2) | CA3030208A1 (https=) |
| DK (1) | DK3497117T5 (https=) |
| LT (1) | LT3497117T (https=) |
| SG (1) | SG11201901066UA (https=) |
| WO (2) | WO2018029158A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規なｅｇｆｒ結合タンパク質 |
| JP6856938B2 (ja) | 2015-07-16 | 2021-04-14 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用 |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CN109963864B (zh) * | 2016-08-11 | 2024-01-02 | 瑞普利金公司 | 用于亲和色谱的碱性稳定性fc结合蛋白 |
| US11779860B2 (en) | 2017-08-07 | 2023-10-10 | Repligen Corporation | Fc binding proteins with cysteine in the C-terminal helical region |
| EP3521304B9 (en) * | 2018-02-01 | 2023-10-04 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| EP3546476A1 (en) * | 2018-03-26 | 2019-10-02 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| CN112969708B (zh) * | 2018-11-12 | 2024-07-05 | 纳维格蛋白质有限公司 | 缺乏免疫球蛋白fc结构域结合亲和力的新三螺旋多肽及其用途 |
| EP3650465A1 (en) * | 2018-11-12 | 2020-05-13 | Navigo Proteins Gmbh | Novel populations of polypeptides having a triple-helical structure |
| MX2021007283A (es) | 2018-12-18 | 2021-07-15 | Navigo Proteins Gmbh | Proteinas de union especificas del folr1 novedosas para diagnostico y tratamiento del cancer. |
| CN113348176A (zh) * | 2019-02-01 | 2021-09-03 | 纳维格蛋白质有限公司 | 用于亲和纯化的免疫球蛋白结合蛋白 |
| GB201904125D0 (en) | 2019-03-26 | 2019-05-08 | Ge Healthcare Bio Sciences Ab | Method for sanitization of a chromatography column |
| JP7432813B2 (ja) * | 2019-09-10 | 2024-02-19 | 東ソー株式会社 | 免疫グロブリン結合性タンパク質 |
| EP4077357B1 (en) * | 2019-12-17 | 2023-09-06 | Navigo Proteins Gmbh | Binding proteins for the enzyme acid alpha glucosidase (gaa) and uses thereof |
| WO2021165395A1 (en) * | 2020-02-21 | 2021-08-26 | Navigo Proteins Gmbh | Affinity ligand for the soluble part of fibroblast growth factor receptor 3 (sfgfr3) |
| EP3875472A1 (en) * | 2020-03-06 | 2021-09-08 | Navigo Proteins Gmbh | Novel immunoglobulin binding polypeptides |
| WO2021260052A1 (en) * | 2020-06-23 | 2021-12-30 | Navigo Proteins Gmbh | Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (sars-cov-2) |
| EP4132943B1 (en) * | 2020-07-15 | 2024-05-29 | Navigo Proteins Gmbh | Immunoglobulin binding proteins for affinity purification |
| JP7854204B2 (ja) * | 2020-11-09 | 2026-05-01 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｉｉ型コラーゲン結合タンパク質 |
| EP4001301A1 (en) * | 2020-11-13 | 2022-05-25 | Navigo Proteins Gmbh | Binding protein for complement factor h (cfh) |
| WO2023012321A1 (en) * | 2021-08-06 | 2023-02-09 | Roche Diagnostics Gmbh | Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
| CN116679071B (zh) * | 2021-12-21 | 2026-02-17 | 百林科(兰州)新材料有限公司 | 免疫检测方法 |
| CN113999294B (zh) * | 2021-12-30 | 2022-03-29 | 苏州纳微科技股份有限公司 | 免疫球蛋白结合蛋白及其应用 |
| CN114409748A (zh) * | 2022-01-28 | 2022-04-29 | 博格隆(浙江)生物技术有限公司 | 蛋白a的b结构域和z结构域突变体及其应用 |
| GB202203478D0 (en) | 2022-03-14 | 2022-04-27 | Cytiva Bioprocess R & D Ab | Vh3 binding polypeptides |
| AU2023395034A1 (en) * | 2022-12-16 | 2025-07-31 | Navigo Proteins Gmbh | New ligands for affinity chromatography |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| EP4541444A1 (en) * | 2023-10-20 | 2025-04-23 | Cytiva BioProcess R&D AB | Fusion protein for affinity capture |
| WO2025262100A1 (en) * | 2024-06-18 | 2025-12-26 | Navigo Proteins Gmbh | New ligands for the purification of antibodies via affinity chromatography |
| WO2026057420A1 (en) | 2024-09-10 | 2026-03-19 | Cytiva Bioprocess R&D Ab | Affinity ligand for purification of antibodies of isotype iga |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| US5629167A (en) * | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| WO1996003506A2 (en) * | 1994-07-21 | 1996-02-08 | Connaught Laboratories Limited | Analog of haemophilus hin47 with reduced protease activity |
| US5958684A (en) | 1995-10-02 | 1999-09-28 | Van Leeuwen; Frederik Willem | Diagnosis of neurodegenerative disease |
| WO1997016556A1 (en) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase i |
| US5789166A (en) | 1995-12-08 | 1998-08-04 | Stratagene | Circular site-directed mutagenesis |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| WO1998054312A1 (en) | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| US20030045681A1 (en) | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| AU2001239470A1 (en) | 2000-02-24 | 2001-09-03 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| JP2003524018A (ja) | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| US6799121B2 (en) | 2000-03-30 | 2004-09-28 | York University | Sequencing of peptides by mass spectrometry |
| US20110179531A1 (en) | 2000-05-09 | 2011-07-21 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| CA2473144C (en) * | 2002-02-05 | 2013-05-28 | Genentech, Inc. | Protein purification |
| SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| US20040043386A1 (en) | 2002-08-30 | 2004-03-04 | Todd Pray | Methods and compositions for functional ubiquitin assays |
| US7563869B2 (en) | 2003-01-23 | 2009-07-21 | Ono Pharmaceutical Co., Ltd. | Substance specific to human PD-1 |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| WO2005044845A2 (en) | 2003-11-04 | 2005-05-19 | Yale University | Protein binding miniature proteins |
| US7393918B2 (en) | 2003-12-11 | 2008-07-01 | Yale University | Protein binding miniature proteins and uses thereof |
| DE10360483B4 (de) | 2003-12-22 | 2007-11-15 | Scil Proteins Gmbh | Expressionsvektor und dessen Verwendung |
| DE102004014983A1 (de) | 2004-03-26 | 2005-10-20 | Univ Stuttgart | Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung |
| DE102004049479A1 (de) | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
| JP2006304633A (ja) * | 2005-04-26 | 2006-11-09 | Apro Life Science Institute Inc | イムノグロブリン結合タンパク質 |
| CA2607954A1 (en) | 2005-05-11 | 2006-11-16 | Philogen S.P.A. | Conjugate for targeting of drug |
| MY185597A (en) * | 2005-09-20 | 2021-05-24 | Avantor Performance Mat Inc | Vegetarian protein a preparation and methods thereof |
| ATE463512T1 (de) | 2005-11-09 | 2010-04-15 | Morphosys Ag | Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern |
| EP1842553A1 (en) | 2006-04-07 | 2007-10-10 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti-EDb fibronectin domain antibody/IL2 fusion protein and a further small molecule |
| CA2648484A1 (en) | 2006-05-08 | 2007-11-15 | Philogen Spa | Antibody-targeted cytokines for therapy |
| EP1892248A1 (en) | 2006-08-21 | 2008-02-27 | Eidgenössische Technische Hochschule Zürich | Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase |
| WO2008039141A1 (en) * | 2006-09-29 | 2008-04-03 | Ge Healthcare Bio-Sciences Ab | Chromatography ligand comprising domain c from staphyloccocus aureus protein a for antibody isolation |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| EP1955712A1 (en) | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| ES2538122T3 (es) | 2008-07-21 | 2015-06-17 | Apogenix Gmbh | Moléculas de una sola cadena de TNFSF |
| US8592555B2 (en) * | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| RU2553333C2 (ru) | 2009-12-14 | 2015-06-10 | Сцил Протеинс Гмбх | Способ идентификации гетеромультимерных модифицированных убиквитиновых белков со способностью связываться с лигандами |
| WO2011118699A1 (ja) * | 2010-03-24 | 2011-09-29 | 株式会社カネカ | 免疫グロブリンに特異的に結合するタンパク質および免疫グロブリン結合性アフィニティーリガンド |
| EP2690173B1 (en) * | 2011-03-25 | 2019-07-03 | Kaneka Corporation | Protein for affinity-separation matrix |
| SG186552A1 (en) | 2011-06-08 | 2013-01-30 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| CA2837804C (en) | 2011-06-15 | 2018-03-20 | Scil Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
| EP2861616A1 (en) | 2012-06-13 | 2015-04-22 | Scil Proteins GmbH | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| EP2899271B1 (en) | 2012-09-21 | 2018-07-25 | Kaneka Corporation | Protein ligand for affinity isolation matrix |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| EP3019520B1 (en) * | 2013-07-10 | 2019-12-11 | GE Healthcare BioProcess R&D AB | Mutated immunoglobulin-binding polypeptides |
| KR102236367B1 (ko) | 2013-07-26 | 2021-04-05 | 삼성전자주식회사 | DARPin을 포함하는 이중 특이 키메라 단백질 |
| US11566082B2 (en) * | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規なｅｇｆｒ結合タンパク質 |
| WO2016124670A1 (en) | 2015-02-06 | 2016-08-11 | Scil Proteins Gmbh | Novel binding proteins comprising a ubiquitin mutein and antibodies or antibody fragments |
| JP6856938B2 (ja) | 2015-07-16 | 2021-04-14 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用 |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| DK3325514T3 (da) | 2015-07-20 | 2019-12-16 | Navigo Proteins Gmbh | Her2-bindende proteiner baseret på di-ubiquitin-muteiner |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CN109963864B (zh) * | 2016-08-11 | 2024-01-02 | 瑞普利金公司 | 用于亲和色谱的碱性稳定性fc结合蛋白 |
| US11779860B2 (en) | 2017-08-07 | 2023-10-10 | Repligen Corporation | Fc binding proteins with cysteine in the C-terminal helical region |
| EP3521304B9 (en) | 2018-02-01 | 2023-10-04 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
-
2017
- 2017-08-07 CN CN201780050413.2A patent/CN109963864B/zh active Active
- 2017-08-07 EP EP17752349.5A patent/EP3497117B1/en active Active
- 2017-08-07 JP JP2019505354A patent/JP7181612B2/ja active Active
- 2017-08-07 EP EP22193930.9A patent/EP4177260A1/en active Pending
- 2017-08-07 AU AU2017311542A patent/AU2017311542B2/en not_active Ceased
- 2017-08-07 CA CA3030208A patent/CA3030208A1/en active Pending
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- 2017-08-07 CN CN202210871980.7A patent/CN116333065A/zh active Pending
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- 2017-08-07 SG SG11201901066UA patent/SG11201901066UA/en unknown
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2021
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2024
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