KR102559639B1 - Shampoo composition and preparation method thereof - Google Patents

Abstract

A composition for shampoo is disclosed. The shampoo composition according to the embodiment can improve inflammation without damaging the scalp while including the hair loss prevention functional ingredient notified by the Ministry of Food and Drug Safety. Furthermore, as a shampoo, it has excellent bubble formation, excellent rinseability, and can impart flexibility to hair.

Description

Shampoo composition and preparation method thereof {Shampoo composition and preparation method thereof}

The examples below relate to shampoo compositions and methods of making them. In particular, it relates to a shampoo composition that does not damage the scalp while containing a hair loss prevention functional ingredient notified by the Ministry of Food and Drug Safety.

The scalp is composed of epidermis, dermis, and subcutaneous tissue, and the outermost tissue is the epidermis. The epidermis serves to protect the body's sensitive tissues from damage. However, various physical and chemical external stimuli, such as changes in external temperature and humidity, pollutants, stress, lack of influence, etc. may cause loss of function of the scalp, and may further affect hair loss. In addition, in modern society where beauty is emphasized, many people, regardless of age or gender, use hair dyes, permanent agents, etc. to satisfy the desire for individual expression. However, in the case of some sensitive scalps, chemical procedures such as dyeing and perming cause irritation and inflammation such as itching or stinging of the scalp, which leads to environmental hair loss.

In this way, research on a component that protects the scalp from environmental stimulation, stress, chemical procedures, etc. caused by various causes, promotes hair growth while preventing hair loss, and is ecologically friendly and harmless to the environment and humans is ongoing. There have also been many attempts to improve the condition of the scalp and hair by applying or taking herbal medicine extracts on the scalp. In the case of using milkweed extract (Korean Patent No. 1537773), in the case of using rose flower extract, folding screen extract, green tea extract, mugwort extract, etc. (Korean Patent No. 1509608), etc. have been disclosed. By having only the function, there are disadvantages such as lack of hair improvement or scalp improvement function.

There are few ingredients notified by the Ministry of Food and Drug Safety as functional ingredients that actually play a role in preventing hair loss, and there is a need to develop a composition that is improved so as not to damage the scalp while including them and has an excellent formulation as a shampoo.

Embodiments are aimed at providing a shampoo composition that can improve inflammation without damaging the scalp while including a hair loss prevention functional ingredient notified by the Ministry of Food and Drug Safety.

As one aspect for solving the above problems, the present invention is a shampoo composition comprising a herbal complex fermented product as an active ingredient for improving scalp inflammation,

The herbal medicine complex fermented product is characterized by fermenting Angelica gigas root, Gosam root, Swallowtail root, Chichi root, Mulberry root, Hojanggeun root, and Calamus root in the presence of Streptococcus thermophilus and Aspergillus oryzae . It provides a shampoo composition.

According to one embodiment, in the crude drug complex fermentation product, the medium composition for preparing the culture medium is formulated and mixed in a weight ratio of 10 to 15 parts by weight of peptone, 3 to 7 parts by weight of yeast extract, 0.5 to 2 parts by weight of malt extract, 1 to 3 parts by weight of glucose, and 60 to 80 parts by weight of distilled water, and Streptococcus thermophilus in the culture medium (Streptococcus thermophilus) and Aspergillus orize (Aspergillus oryzae) is added, and after cooling to a temperature of 35 to 40 ° C., inoculating the microbial strain into the culture solution and culturing for 20 to 60 hours, 8 to 12 parts by weight of Angelica gigas root, 8 to 12 parts by weight of Kosam root, 8 to 12 parts by weight of Sage root, 8 to 12 parts by weight of Chichi root, 8 to 12 parts by weight of mulberry root, 8 to 12 parts by weight of Knotweed root. It may be obtained by mixing 12 parts by weight and 8 to 12 parts by weight of calamus root, further culturing at a temperature of 35 to 40 ° C. for 20 to 60 hours, followed by filtering and drying.

According to one embodiment, 1.0 to 3.0% by weight of the fermented herbal medicine complex is included relative to the weight of the total shampoo composition, and as an anti-hair loss component, 0.1 to 0.3% by weight of biotin, 0.3 to 0.5% by weight of nicotinamide, and 0.6 to 0.8% by weight of dexpanthenol, and 33.0 to 37.0% by weight of potassium cocoyl glycinate and sodium as surfactants 8.0 to 12.0% by weight of cocoyl isethionate, and 2.5 to 3.5% by weight of xanthan gum as a viscosity modifier may be included.

According to one embodiment, as a conditioning agent, 0.8 to 1.2% by weight of dimethicone and 0.6 to 1.0% by weight of polyquaternium-10 are included, and as additives, 0.8 to 1.2% by weight of caprylyl glycol, 0.4 to 0.6% by weight of salicylic acid, and 0.4 to 0.6% by weight of ascorbic acid may be included.

An apparatus according to an embodiment may be combined with hardware and controlled by a computer program stored in a medium to execute any one of the methods described above.

The shampoo composition according to the embodiment can improve inflammation without damaging the scalp while including the hair loss prevention functional ingredient notified by the Ministry of Food and Drug Safety. Furthermore, as a shampoo, it has excellent bubble formation, excellent rinseability, and can impart flexibility to hair.

Hereinafter, embodiments will be described in detail with reference to the accompanying drawings. However, since various changes can be made to the embodiments, the scope of the patent application is not limited or limited by these embodiments. It should be understood that all changes, equivalents or substitutes to the embodiments are included within the scope of rights.

Specific structural or functional descriptions of the embodiments are disclosed for illustrative purposes only, and may be modified and implemented in various forms. Therefore, the embodiments are not limited to the specific disclosed form, and the scope of the present specification includes changes, equivalents, or substitutes included in the technical spirit.

Although terms such as first or second may be used to describe various components, such terms should only be construed for the purpose of distinguishing one component from another. For example, a first element may be termed a second element, and similarly, a second element may be termed a first element.

It should be understood that when an element is referred to as being “connected” to another element, it may be directly connected or connected to the other element, but other elements may exist in the middle.

Terms used in the examples are used only for descriptive purposes and should not be construed as limiting. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as "comprise" or "having" are intended to specify that a feature, number, step, operation, component, part, or combination thereof described in the specification exists, but it should be understood that the presence or addition of one or more other features or numbers, steps, operations, components, parts, or combinations thereof is not excluded in advance.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by a person of ordinary skill in the art to which the embodiment belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and are not interpreted in an ideal or excessively formal meaning unless explicitly defined in the present application.

Advantages and features of the present invention, and methods of achieving them, will become clear with reference to the detailed description of the following embodiments taken in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in a variety of different forms, and only these embodiments make the disclosure of the present invention complete, and those skilled in the art It is provided to completely inform the scope of the invention, and the present invention is only defined by the scope of the claims.

In the embodiments of the present invention, unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and unless explicitly defined in the embodiments of the present invention, an ideal or excessively formal meaning. It is not to be interpreted.

The shapes, sizes, ratios, angles, numbers, etc. disclosed in the drawings for explaining the embodiments of the present invention are illustrative, so the present invention is not limited to the details shown. In addition, in describing the present invention, if it is determined that a detailed description of related known technologies may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted. When 'includes', 'has', 'consists of', etc. mentioned in this specification is used, other parts may be added unless 'only' is used. In the case where a component is expressed in the singular, the case including the plural is included unless otherwise explicitly stated.

In interpreting the components, even if there is no separate explicit description, it is interpreted as including the error range.

The size and thickness of each component shown in the drawings are shown for convenience of description, and the present invention is not necessarily limited to the size and thickness of the illustrated components.

Each feature of the various embodiments of the present invention can be partially or entirely combined or combined with each other, and as those skilled in the art can fully understand, various interlocking and driving are possible technically, and each embodiment can be implemented independently of each other. It may be possible to implement together in a related relationship.

Hereinafter, the configuration of the present invention and its effects will be described in more detail through specific examples and comparative examples. However, these examples are for explaining the present invention in more detail, and the scope of the present invention is not limited to these examples.

Preparation Example 1. Preparation of herbal medicine composite fermented product

Streptococcus thermophilus and Aspergillus oryzae were cultured in a culture medium containing 10 g of peptone, 5 g of yeast extract, 1 g of malt extract, 2 g of glucose, and 80 g of water. After culturing at 37 ° C. for 24 hours, a fermented product was obtained.

A dried mixture of 10 g of angelica root, 10 g of sorghum root, 10 g of sage root, 10 g of chichi root, 10 g of mulberry root, 10 g of Japanese knotweed root, and 10 g of calamus root was mixed with the culture solution and allowed to stand at 37° C. for an additional 24 hours. Filter the medicinal materials using a 380 mesh filter and filter with a 11 μm paper filter. The entire filtrate was filtered under reduced pressure using a 0.45 μm membrane filter, filtered in a filtration device, and then lyophilized to obtain the fermented crude drug complex of Example 1.

Comparative Examples 1 to 4 were prepared in the same manner as in Example 1, with only the composition shown in Table 1.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 microbial strains Streptococcus thermophilus + Aspergillus orize Streptococcus thermophilus Aspergillus Orize Streptococcus thermophilus + Aspergillus orize Streptococcus thermophilus + Aspergillus orize Angelica root 10g 10g 10g 12g 12g Gosam Root 10g 10g 10g 12g 12g sewage root 10g 10g 10g 12g 12g chichi root 10g 10g 10g 12g 12g Mulberry Root 10g 10g 10g 12g 12g Japanese knotweed root 10g 10g 10g 0g 10g calamus root 10g 10g 10g 10g 0g

Experimental Example 1. Anti-inflammatory and antioxidant evaluation

For evaluation, Examples and Comparative Examples were prepared by dissolving them in ethanol to 100 μm.

For anti-inflammatory measurement, HaCaT cells are seeded in a 24-well plate at a concentration of 1x10 ⁵ . The day after sowing, the concentration of FBS was lowered to 2%, the culture medium was replaced with a medium for analysis of IL-8 from which phenol red was removed, and dandruff and fatty acids were treated. After 24 hours of material treatment, the culture medium of the cells is collected, and the remaining cells are washed twice with PBS, and then cytotoxicity is evaluated using WST-1 (Roche) reagent. The collected medium is centrifuged to remove the residue, and the concentration of IL-8 in the medium is measured using an IL-8 ELISA set (BD Bioscience). WST-1 and IL-8 ELISA follow the protocol provided by the manufacturer.

For antioxidant measurement, DPPH (2,2-Diphenyl-1-picrylhydrazyl) was dissolved in ethanol to make 100 μM. The material to be reacted with the DPPH solution is dissolved in ethanol at the final treatment concentration x20. A substance to be treated is put into a 96-well plate by 10 μl for each concentration. At this time, the number of treatments with the same concentration is three times for each substance treatment concentration section. 10 μl of ethanol is added to the control group. 100 μM DPPH was added using a multichannel pipette by 190 μl. After that, it is stored for 30 minutes in a 37°C incubator. Absorbance at 517 nm is measured using Spectra Max 190. Calculate the change rate of the material treatment group based on the control group.

IL-8 expression level (% compared to control group) Antioxidant efficacy (% compared to control) Example 1 35% 18% Comparative Example 1 56% 74% Comparative Example 2 75% 58% Comparative Example 3 83% 56% Comparative Example 4 54% 48%

As described above, it can be confirmed that Example 1 relieves inflammation and has high antioxidant efficacy compared to Comparative Example.

Preparation Example 2. Preparation of shampoo composition

It is confirmed that the composition of Example 1 can alleviate inflammation of the hair, and it is intended to provide a shampoo composition having a suitable formulation including it.

(weight%) ingredient name Prescription Example 1 Comparative Prescription Example 1 Comparative Prescription Example 2 Comparative prescription example 3 Comparative prescription example 4 Comparative prescription example 5 Purified water Purified water To 100 To 100 To 100 To 100 To 100 To 100 Scalp soothing active ingredient Complex fermented herbal medicine of Example 1 2.0 2.0 2.0 2.0 2.0 2.0 hair loss prevention ingredient biotin 0.2 0.2 0.2 0.2 0.2 0.2 nicotinic acid amide 0.4 0.4 0.4 0.4 0.4 0.4 dexpanthenol 0.7 0.7 0.7 0.7 0.7 0.7 Surfactants Cocamidopropyl Betaine 35.0 Potassium Cocoyl Glycinate 35.0 35.0 35.0 32.0 38.0 sodium cocoyl isethionate 10.0 10.0 10.0 10.0 10.0 10.0 conditioning agent dimethicone 1.0 1.0 1.0 1.0 1.0 1.0 Polyquaternium-10 0.8 0.8 0.8 0.8 0.8 0.8 viscosity modifier xanthan gum 3.0 3.0 2.0 4.0 3.0 3.0 additive caprylyl glycol 1.0 1.0 1.0 1.0 1.0 1.0 salicylic acid 0.5 0.5 0.5 0.5 0.5 0.5 Ascorbic Acid 0.5 0.5 0.5 0.5 0.5 0.5

Experimental Example 2. Use quality test

The quality of use was evaluated by a panel consisting of 10 women aged 20 to 30 years. Specifically, after using the shampoos of the Prescription Example and the Comparative Prescription Example every day for 2 weeks, the quality of use was evaluated in such a way that the following questionnaire was answered on a 7-point scale (higher score is better). The results are shown in Table 4 below.

Prescription Example 1 Comparative Prescription Example 1 Comparative Prescription Example 2 Comparative prescription example 3 Comparative prescription example 4 Comparative prescription example 5 1. It foams well and has a good bubble feeling 6.1 6.0 6.1 5.1 4.9 4.8 2. Feels good when rinsing and goes through fingers well 5.6 4.5 3.5 4.2 3.8 4.2 3. Combing is easy and soft when semi-dry 5.8 5.7 4.6 3.1 3.7 4.1 4. After drying, hair care is easy and soft 4.5 4.3 4.8 4.6 3.1 4.2 5. After drying, the scalp and hair roots feel refreshed. 5.7 4.3 5.2 5.1 4.8 3.5 6. The condition of the scalp becomes clear (to the extent that there are no pimples or erythema on the scalp) 5.8 4.1 5.1 4.9 4.3 4.8

In the case of using the prescription example, it can be confirmed that the shampoo has a superior formulation than the case of using the comparative prescription examples, and the itching of the scalp is greatly improved and the scalp condition is cleared.

Claims (3)

A composition for shampoo comprising a herbal complex fermented product as an active ingredient for improving scalp inflammation,
The crude drug complex fermented product,
(i) 10 to 15 parts by weight of peptone, 3 to 7 parts by weight of yeast extract, 0.5 to 2 parts by weight of malt extract, 1 to 3 parts by weight of glucose, and 60 to 80 parts by weight of distilled water are added to a mixture of strains of Streptococcus thermophilus and Aspergillus oryzae, and After culturing for 20 to 60 hours at a temperature to prepare a culture medium,
(ii) 8 to 12 parts by weight of angelica root, 8 to 12 parts by weight of sorghum root, 8 to 12 parts by weight of sage root, 8 to 12 parts by weight of chichi root, 8 to 12 parts by weight of mulberry root, 8 to 12 parts by weight of hornbeam root, and 8 to 12 parts by weight of calamus root were mixed with the culture solution and further cultured at a temperature of 35 to 40 ° C. for 20 to 60 hours After,
(iii) a composition for shampoo that is obtained by filtration and drying.
delete According to claim 1,
1.0 to 3.0% by weight of the herbal medicine complex fermented product relative to the weight of the total shampoo composition,
As an anti-hair loss component, 0.1 to 0.3% by weight of biotin, 0.3 to 0.5% by weight of nicotinic acid amide, and 0.6 to 0.8% by weight of dexpanthenol,
As a surfactant, 33.0 to 37.0% by weight of potassium cocoyl glycinate and 8.0 to 12.0% by weight of sodium cocoyl isethionate are included,
A composition for shampoo comprising 2.5 to 3.5% by weight of xanthan gum as a viscosity modifier.