KR102556554B1 - 난소암에 사용할 수 있는 응집 유도 방출 효과를 가진 수용성 형광 프로브와 나노 입자 및 이의 제조 방법과 응용 - Google Patents
난소암에 사용할 수 있는 응집 유도 방출 효과를 가진 수용성 형광 프로브와 나노 입자 및 이의 제조 방법과 응용 Download PDFInfo
- Publication number
- KR102556554B1 KR102556554B1 KR1020217003640A KR20217003640A KR102556554B1 KR 102556554 B1 KR102556554 B1 KR 102556554B1 KR 1020217003640 A KR1020217003640 A KR 1020217003640A KR 20217003640 A KR20217003640 A KR 20217003640A KR 102556554 B1 KR102556554 B1 KR 102556554B1
- Authority
- KR
- South Korea
- Prior art keywords
- lysophosphatidic acid
- molecular probe
- water
- fluorescent
- aggregation
- Prior art date
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1003—Carbocyclic compounds
- C09K2211/1007—Non-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1044—Heterocyclic compounds characterised by ligands containing two nitrogen atoms as heteroatoms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6432—Quenching
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810727137.5 | 2018-07-05 | ||
CN201810727137.5A CN110684014B (zh) | 2018-07-05 | 2018-07-05 | 可用于卵巢癌的一种具有聚集诱导发射效应的水溶性荧光探针和纳米粒及其制备方法和应用 |
PCT/CN2019/092455 WO2020007210A1 (zh) | 2018-07-05 | 2019-06-24 | 可用于卵巢癌的一种具有聚集诱导发射效应的水溶性荧光探针和纳米粒及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20210029793A KR20210029793A (ko) | 2021-03-16 |
KR102556554B1 true KR102556554B1 (ko) | 2023-07-17 |
Family
ID=69059822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020217003640A KR102556554B1 (ko) | 2018-07-05 | 2019-06-24 | 난소암에 사용할 수 있는 응집 유도 방출 효과를 가진 수용성 형광 프로브와 나노 입자 및 이의 제조 방법과 응용 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20210269421A1 (zh) |
KR (1) | KR102556554B1 (zh) |
CN (1) | CN110684014B (zh) |
WO (1) | WO2020007210A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114105899B (zh) * | 2020-08-31 | 2023-10-10 | 湖南超亟检测技术有限责任公司 | 一种近红外荧光分子探针的构建及其在微量元素测定中的应用 |
CN113929659B (zh) * | 2021-10-12 | 2022-07-15 | 三峡大学 | 一种具有aie性质的压力致变色材料的制备及其应用 |
CN114989080B (zh) * | 2022-05-23 | 2023-12-22 | 井冈山大学 | 一种荧光化合物及其制备方法和应用以及一种荧光试条 |
CN116574504B (zh) * | 2023-06-08 | 2024-04-05 | 合肥工业大学 | 一种基于aie脂质体荧光纳米粒子检测腐胺的方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106699734A (zh) * | 2016-12-19 | 2017-05-24 | 中南大学 | 一种荧光分子探针和纳米探针及其制备方法和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106632305B (zh) * | 2016-12-09 | 2019-06-28 | 中南大学 | 一种具有水溶性及聚集诱导发射效应的荧光探针和纳米粒及制备方法和应用 |
-
2018
- 2018-07-05 CN CN201810727137.5A patent/CN110684014B/zh active Active
-
2019
- 2019-06-24 WO PCT/CN2019/092455 patent/WO2020007210A1/zh active Application Filing
- 2019-06-24 KR KR1020217003640A patent/KR102556554B1/ko active IP Right Grant
- 2019-06-24 US US17/257,884 patent/US20210269421A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106699734A (zh) * | 2016-12-19 | 2017-05-24 | 中南大学 | 一种荧光分子探针和纳米探针及其制备方法和应用 |
Non-Patent Citations (2)
Title |
---|
Dibenzo[a,c]phenazine-derived near-infrared fluorescence biosensor for detection of lysophosphatidic acid based on aggregation induced emission. T. Jiang et al.. RSC Advances. 1995, Vol 5, pp. 102863-102867* |
T. Gao et al.. Chemical Communications, 2018, Vol. 54, pp. 3578-3581 |
Also Published As
Publication number | Publication date |
---|---|
US20210269421A1 (en) | 2021-09-02 |
WO2020007210A1 (zh) | 2020-01-09 |
CN110684014A (zh) | 2020-01-14 |
KR20210029793A (ko) | 2021-03-16 |
CN110684014B (zh) | 2023-05-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR102556554B1 (ko) | 난소암에 사용할 수 있는 응집 유도 방출 효과를 가진 수용성 형광 프로브와 나노 입자 및 이의 제조 방법과 응용 | |
Li et al. | Recent progress in fluorescent probes for metal ion detection | |
Huang et al. | Revealing aggregation-induced emission effect of imidazolium derivatives and application for detection of Hg2+ | |
CN110172337B (zh) | 一种苯并噻唑衍生物荧光探针及其制备方法和应用 | |
CN106970061A (zh) | 碳点/铜纳米簇复合物比率荧光多巴胺探针的制备方法 | |
CN106699734B (zh) | 一种荧光分子探针和纳米探针及其制备方法和应用 | |
CN106281304B (zh) | 一种可用于活细胞内丙二醛成像的荧光探针及其制备方法 | |
CN113461609B (zh) | 一种硫酸酯酶响应的aie纳米探针及其制备方法与应用 | |
CN113801105A (zh) | 线粒体靶向的过氧亚硝酸根/亚硫酸氢根双响应荧光探针 | |
CN111675674B (zh) | 一种aie分子及其合成方法 | |
CN107739394B (zh) | 一种用于铜离子荧光检测的超分子自组装体及其制备方法与应用 | |
CN114478473A (zh) | 一种亮氨酸氨基肽酶化学发光检测试剂的合成及应用 | |
Wang et al. | One-pot synthesis of fluorescent and cross-linked polyphosphazene nanoparticles for highly sensitive and selective detection of dopamine in body fluids | |
CN117233377A (zh) | 时空分辨光学信号编码方法 | |
CN110642857B (zh) | 一种用于检测粘度和pH的双功能荧光探针及其制备与应用 | |
CN110372681B (zh) | 一种用于选择性检测人血清白蛋白的自组装纳米荧光探针的应用 | |
CN110357817B (zh) | 一类可逆性检测丙酮醛和乙二醛荧光探针及其制备方法和应用 | |
CN110627737A (zh) | 一种检测锌离子的水溶性苯并恶唑类荧光探针及制备方法和应用 | |
CN112159381B (zh) | 一种aie型香豆素衍生物荧光探针及其制备方法和应用 | |
CN110229203B (zh) | 一种氨基己糖酶荧光探针及其制备方法和应用 | |
CN112876426B (zh) | 检测人血清白蛋白的苯并噻唑类荧光探针及制备和试剂盒 | |
CN102633790B (zh) | 吡啶罗丹明噁二唑化合物及其制备方法与应用 | |
CN112794819A (zh) | 一种基于分子异构化机理的可用于铁离子特异性检测的新型荧光探针的制备方法及应用 | |
CN114106351B (zh) | 一种比率型超分子自组装荧光探针及其制备方法及应用 | |
CN115745991B (zh) | 一种靶向溶酶体的检测so2衍生物或粘度比率荧光探针及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant |