KR102556554B1 - 난소암에 사용할 수 있는 응집 유도 방출 효과를 가진 수용성 형광 프로브와 나노 입자 및 이의 제조 방법과 응용 - Google Patents

난소암에 사용할 수 있는 응집 유도 방출 효과를 가진 수용성 형광 프로브와 나노 입자 및 이의 제조 방법과 응용 Download PDF

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KR102556554B1
KR102556554B1 KR1020217003640A KR20217003640A KR102556554B1 KR 102556554 B1 KR102556554 B1 KR 102556554B1 KR 1020217003640 A KR1020217003640 A KR 1020217003640A KR 20217003640 A KR20217003640 A KR 20217003640A KR 102556554 B1 KR102556554 B1 KR 102556554B1
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lysophosphatidic acid
molecular probe
water
fluorescent
aggregation
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KR20210029793A (ko
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웨이빈 정
스 리
주위엔 리우
쉬에옌 황
탕 가오
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후난 타겟팅 디텍션 테크놀로지 컴퍼니 리미티드
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KR1020217003640A 2018-07-05 2019-06-24 난소암에 사용할 수 있는 응집 유도 방출 효과를 가진 수용성 형광 프로브와 나노 입자 및 이의 제조 방법과 응용 KR102556554B1 (ko)

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CN201810727137.5 2018-07-05
CN201810727137.5A CN110684014B (zh) 2018-07-05 2018-07-05 可用于卵巢癌的一种具有聚集诱导发射效应的水溶性荧光探针和纳米粒及其制备方法和应用
PCT/CN2019/092455 WO2020007210A1 (zh) 2018-07-05 2019-06-24 可用于卵巢癌的一种具有聚集诱导发射效应的水溶性荧光探针和纳米粒及其制备方法和应用

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CN114105899B (zh) * 2020-08-31 2023-10-10 湖南超亟检测技术有限责任公司 一种近红外荧光分子探针的构建及其在微量元素测定中的应用
CN113929659B (zh) * 2021-10-12 2022-07-15 三峡大学 一种具有aie性质的压力致变色材料的制备及其应用
CN114989080B (zh) * 2022-05-23 2023-12-22 井冈山大学 一种荧光化合物及其制备方法和应用以及一种荧光试条
CN116574504B (zh) * 2023-06-08 2024-04-05 合肥工业大学 一种基于aie脂质体荧光纳米粒子检测腐胺的方法

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CN106699734A (zh) * 2016-12-19 2017-05-24 中南大学 一种荧光分子探针和纳米探针及其制备方法和应用

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CN106632305B (zh) * 2016-12-09 2019-06-28 中南大学 一种具有水溶性及聚集诱导发射效应的荧光探针和纳米粒及制备方法和应用

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Publication number Priority date Publication date Assignee Title
CN106699734A (zh) * 2016-12-19 2017-05-24 中南大学 一种荧光分子探针和纳米探针及其制备方法和应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Dibenzo[a,c]phenazine-derived near-infrared fluorescence biosensor for detection of lysophosphatidic acid based on aggregation induced emission. T. Jiang et al.. RSC Advances. 1995, Vol 5, pp. 102863-102867*
T. Gao et al.. Chemical Communications, 2018, Vol. 54, pp. 3578-3581

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CN110684014A (zh) 2020-01-14
KR20210029793A (ko) 2021-03-16
CN110684014B (zh) 2023-05-16

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